Inclusion and Functionalization of Polymers with Cyclodextrins: Current Applications and Future Prospects

Abstract

Abstract:The numerous hydroxyl groups available in cyclodextrins are active sites that can form different types of linkages. They can be crosslinked with one another, or they can be derivatized to produce monomers that can form linear or branched networks. Moreover, they can form inclusion complexes with polymers and different substrates, modifying their physicochemical properties. This review shows the different applications using polymers with cyclodextrins, either by forming inclusion complexes, ternary complexes, networks, or molecularly imprinted polymers (MIPs). On one hand, the use of cyclodextrins enhances the properties of each polymer, and on the other the use of polymers decreases the amount of cyclodextrins required in different formulations. Both cyclodextrins and polymers contribute synergistically in several applications such as pharmacological, nutritional, environmental, and other industrial fields. The use of polymers based on cyclodextrins is a low cost easy to use potential tool with great future prospects.

TGA/DTA–FTIR–MS coupling as analytical tool for confirming inclusion complexes occurrence in supramolecular host–guest architectures

“…Through complexation, the physical, chemical and biological properties of the guest molecules are modified, representing very efficient drug carriers in controlled drug release. Cyclodextrins may, also, form inclusion complexes with rotaxane and/or pseudorotaxane structures [2,11].…”

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

“…In contrast to polymer drug conjugates, where the drug is generally covalently bound to the polymer, drugs in MIPs are hosted through non-covalent interactions. MIPs based on cyclodextrins (CDs) have been reported in the literature [17]. The presence of CDs within an imprinted polymer network can improve the performance of the MIP [18].…”

Synthesis of multiresponsive β‐cyclodextrin nanocomposite through surface RAFT polymerization for controlled drug delivery

“…In recent studies, β‐cyclodextrin (β‐CD) have a great attention specially due to its structure with a hydrophilic external and a proper inside hydrophobic hollow as a host site for guest drug molecules. This feature gives a valuable scaffold platform for the expansion of magnetic β‐CD polymer hydrogel because of mechanical strength, drug loading, and releasing behavior in drug delivery systems . In addition, β‐CD with excellent binding properties can be formed composites with different biomolecules.…”