Incisional Wound Healing: Model and Analysis of Wound Breaking Strength

Gamelli, Richard L.; He, Li-Ke

doi:10.1385/1-59259-332-1:037

Cited by 23 publications

(34 citation statements)

References 25 publications

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“…Fixation of tissues with formalin followed by hematoxillyn eosin staining is a common method that displays a broad range of cytoplasmic, nuclear, extracellular matrix features (Garmelli and He, 2003). Such data provide additional insights into the status of the healing process, particularly in studies of impaired wound healing (Garmelli and He, 2003). In agreement with previous studies on DX at a higher dose, poor wound healing associated with less epithelialization; fibroblast density were observed in the same rats (Al-Refu, 2011, Murti andKumar, 2011).…”

Section: Discussionsupporting

confidence: 83%

“…The water extract of SK stem bark interfered with the primary phases of wound healing by improving swelling, rate of contraction and epithelialization time. Healing features observed in this For example, therapeutic agents that modulate wound repair can be evaluated based on their influence on the development of wound strength (Garmelli and He, 2003). Furthermore, the increasing amount of stable collagen and the alignment of its fibers gradually increase the strength of the healing wound (Shai and Maibach, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Histopathological examination further provided additional evidence on the wound healing potential of SK stem bark. Fixation of tissues with formalin followed by hematoxillyn eosin staining is a common method that displays a broad range of cytoplasmic, nuclear, extracellular matrix features (Garmelli and He, 2003). Such data provide additional insights into the status of the healing process, particularly in studies of impaired wound healing (Garmelli and He, 2003).…”

Section: Discussionmentioning

confidence: 99%

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In Vivo Wound Healing Effect of Water Extract of Stereospernum kunthianum Stem-Bark

2016

J Med Herbs Ethnomed

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The objective of the present study was to evaluate the in vivo wound healing effect of water extract of Stereospermum kunthianum cham. (SK)-bark. The plant is mainly used by the local people of Mayo-Danay, Cameron as wound healing agent. The healing activity was evaluated in rats using excision and incision wound on normal dexamethasone (DX)-delayed wound healing. Control animals received normal saline topically while other groups received DX (intramuscular [i.m.]), water extract orally or DX with the plant extract. The extract treated wounds were found to epithelize faster than those of controls DX treated rats. A significant increase in skin tensile strength was observed in earlier than in later groups. A histological examination of incision wounds of the extract-treated group showed dense collagen cross-linking and numerous blood vessels. The present study concludes that the stem bark of SK possesses excellent wound healing potential that may substantiate its use in the traditional medicine.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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In Vivo Wound Healing Effect of Water Extract of Stereospernum kunthianum Stem-Bark

2016

J Med Herbs Ethnomed

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“…Subcutaneous Administration of rhMG53 accelerates Wound Healing-We have shown previously that systemic administration of rhMG53 provided dose-dependent protection against injury to muscles and the heart, kidneys, and lungs under various injurious conditions (18 -21). We studied the effect of rhMG53 in protection against dermal injury using established rat models of wound healing (29,30,33). Excisional wounds were created on the back of rats with a biopsy punch (diameter, 6 mm) (Fig.…”

Section: Defective Skin Structure In Mg53mentioning

confidence: 99%

Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair

Duann

Lin

et al. 2015

Journal of Biological Chemistry

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Background: MG53 is a membrane repair gene whose role in wound healing has not been studied. Results: Topical administration of MG53 protein facilitates wound healing and reduces scar formation. Conclusion: This study establishes MG53 as facilitator of injury repair and inhibitor of myofibroblast differentiation during wound healing. Significance: MG53 has therapeutic benefits in treating wounds and fibrotic diseases.

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“…The second method measured tensile strength ex vivo, when porcine skin strips that were glued together are pulled apart by mechanical clamps. Both of these methods have been previously used and reported 8,9 and are used to measure the performance of wound closure devices.…”

Section: Study Protocolmentioning

confidence: 99%

A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives

Singer

Perry²

2012

Academic Emergency Medicine

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Objectives: Topical skin adhesives (TSAs) offer a noninvasive alternative to sutures. The growing trend is to use them in addition to sutures and staples to add strength and provide a microbial barrier. The authors compared the mechanical characteristics of recently approved TSAs that are most likely to be of surgical relevance in the emergency department.Methods: Linear incisions were made on anesthetized swine and the wounds were approximated with one of six commercially available TSAs. Three-dimensional bursting strength was measured with a BTC-2000TM device. Tensile failure force was measured ex vivo using TSA-approximated porcine skin strips with a tensionometer. Resistance to cyclic loading was measured by subjecting approximated skin strips to repetitive cycles of rotational torque and linear tension. Viscosity was measured with a viscometer and setting times were measured by periodically dabbing the adhesive applied to skin strips with a cotton swab to determine whether it was dry.Results: Dermabond Advanced TSA provided significantly (p < 0.00001) greater acute in vivo wound bursting strength and ex vivo tensile force, greater mean number of normal tensile loading cycles to failure (while under continuous torsional cycling), and longest time to failure, and the mean setting time was the shortest.

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Incisional Wound Healing: Model and Analysis of Wound Breaking Strength

Cited by 23 publications

References 25 publications

In Vivo Wound Healing Effect of Water Extract of Stereospernum kunthianum Stem-Bark

In Vivo Wound Healing Effect of Water Extract of Stereospernum kunthianum Stem-Bark

Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair

A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives

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