In Vivo Wound Healing Effect of Water Extract of Stereospernum kunthianum Stem-Bark

Abstract

The objective of the present study was to evaluate the in vivo wound healing effect of water extract of Stereospermum kunthianum cham. (SK)-bark. The plant is mainly used by the local people of Mayo-Danay, Cameron as wound healing agent. The healing activity was evaluated in rats using excision and incision wound on normal dexamethasone (DX)-delayed wound healing. Control animals received normal saline topically while other groups received DX (intramuscular [i.m.]), water extract orally or DX with the plant extract. The extract treated wounds were found to epithelize faster than those of controls DX treated rats. A significant increase in skin tensile strength was observed in earlier than in later groups. A histological examination of incision wounds of the extract-treated group showed dense collagen cross-linking and numerous blood vessels. The present study concludes that the stem bark of SK possesses excellent wound healing potential that may substantiate its use in the traditional medicine.

Phytochemical Screening and Determination of Polyphenols in the Hydro-Ethanolic Extract of Trunk Bark and Its Fractions of Stereospermum kunthianium Cham (Bignoniaceae)

“…Several studies have shown that many biological activities of plant extracts are often linked to their polyphenol content. These are antioxidant [4], anti-inflammatory [5] anti-tumour [6] and healing [7] activities. They also have a stimulating action on immune system cells.…”