Incisional Surgical Site Infection in Kidney Transplantation

Ramos, António; Asensio, Ángel; Múñez, Elena; Torre-Cisneros, J; Montejo, Miguel; Aguado, José María; Cofan, Frederic; Carratalà, Jordi; Len, Óscar; Cisneros, José Miguel

doi:10.1016/j.urology.2007.11.030

Cited by 50 publications

(42 citation statements)

References 23 publications

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“…However, many other studies have noted diabetes as a significant risk factor for wound complications. [11][12][13]18 After stepwise selection, diabetes status did not show significance in the final MLR model in this study, which means that diabetes status had no correlation with major or minor wound complications in our cohort of patients. The majority of diabetic patients (76.21%) had a drain placed in this study (Table 2).…”

mentioning

confidence: 57%

“…001), and patients with diabetes (P = .0025), a well-established risk factor for wound complications, were more likely to have a drain placed. [11][12][13][25][26][27][28][29] Also, Table 2 shows that patients with low preoperative platelet counts were more likely to be assigned to the drain group (203 compared with 175 for ND and D groups) (P < .001).…”

Section: Discussionmentioning

confidence: 99%

“…Prognosticators include diabetes, a high body mass index (BMI), poor nutrition status, delayed graft function (DGF), longer operative times, advanced age, poor surgical technique, and nicotine consumption. 1,[5][6][7][8][9][10][11][12][13] The immunosuppressant regimen plays an integral role in the development of wound issues. Sirolimus, an mTOR inhibitor, has a well-known association with wound complications.…”

Section: Introductionmentioning

confidence: 99%

“…Sirolimus, an mTOR inhibitor, has a well-known association with wound complications. 2,3,[13][14][15][16][17] Mycophenolate mofetil (MMF) may hinder wound healing; however, it is difficult to assess the independent effect of MMF as it is rarely given as a single immunosuppressant agent. 18 Steroids may influence the rate of wound healing, which may increase the incidence of wound complications.…”

Section: Introductionmentioning

confidence: 99%

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Parsikia

Chang

et al. 2014

Exp Clin Transplant

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Objectives: This paper sought to determine if there were an association between drain placement and the incidence of wound complications. Materials and Methods: A single-center institutional review board-approved retrospective study between 2001 to 2008, comparing 680 kidney transplant patients who either had a drain placed or were left undrained. Linear regression modeling was used to adjust the risk factors between the groups. Patients received calcineurin inhibitors, steroids, and a mycophenolate formulation. The incidence of early major and minor wound complications were captured. Minor wound complications were defined as seroma, lymphocele, and perigraft fluid collection, and major wound complications were defined as wound dehiscence, hematomas, evisceration, infections, wound necrosis, and hernias. Patients with incomplete data or those taking sirolimus were excluded. Results: Six hundred eighty kidney transplant cases were reviewed. Four hundred seventy-nine received drains; 201 did not. Demographic analyses revealed that the drain group had a higher average value in age and body mass index. The drain group had a lower albumin and a lower mean platelet count after surgery. The number of patients without diabetes in the drain group numbered nearly twice as many as did those without drains. An attempt was made to statistically account for demographic differences.Seventy-eight of 479 drained patients (16.28%) and 24 of 201 no-drain patients (11.94%) had a wound complication. Minor wound complications were observed in 9 patients (1.88%) in the drain group and 6 in no-drain group (2.99%) (P = .3702). Major wound complications were observed in 58 patients in the drain group (12.18%) and 17 in the no-drain group (8.46%) (P = .1655). Drain placement had no effect on major or minor wound complications. Conclusions: Drain placement is not associated with major or minor wound complications in kidney transplants.

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confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Parsikia

Chang

et al. 2014

Exp Clin Transplant

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“…Previous studies have revealed a median time from transplant to SII of 20 days (range, 2-76 d), which could occasionally appear later, particularly in cases of deep incisional infections or fungal SII. [18][19][20] Most relevant literature results have identified high BMI, DM, acute cellular rejection, reoperation, DGF, sirolimus use, grafts from deceased donors, female recipient, prolonged CIT, and urinary fistula as potential risk factors associated with posttransplant SII in kidney transplant recipients. 8,[20][21][22][23] Our data analyses revealed several interesting results.…”

Section: Discussionmentioning

confidence: 99%

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Moris

Davakis²,

Kakavia³

et al. 2017

Exp Clin Transplant

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Objectives: Surgical incision infections, along with urinary tract infections, are among the most common infective complications after kidney transplant. The aim of this retrospective study is to evaluate the incidence and predisposing factors of surgical incision infection development in renal transplant recipients. Further evaluation of these findings in a prospective study is needed to avoid potential bias.

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