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Moris, Demetrios; Davakis, Spyridon; Kakavia, Kyriaki; Bokos, John; Vernadakis, Spiridon; Diles, Konstantinos; Sotirchos, Georgios; Barlas, Alexandros; Psychogiou, Mina; Zavos, G.

doi:10.6002/ect.2016.0125

Cited by 1 publication

(1 citation statement)

References 31 publications

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“…Prolonged cold ischemia time has been previously identified as a risk factor for incisional infections after kidney transplantation. 1 , 28 Since cold ischemic time is also associated with other adverse events following kidney transplantation, such as delayed graft function, 29 this observation provides further rationale to minimize cold ischemic time whenever possible.…”

Section: Discussionmentioning

confidence: 99%

Surgical site complications in kidney transplant recipients: incidence, risk factors and outcomes in the modern era

Wong

Minkovich

Famure

et al. 2021

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Background: Surgical site complications (SSCs) are an important source of morbidity after kidney transplantation. We assessed the incidence, risk factors, outcomes and economic impact of SSCs in a large, diverse population of kidney transplant recipients. Methods: We conducted a single-centre, observational cohort study of adult (age ≥ 18 yr) patients who underwent kidney transplantation between Jan. 1, 2005, and Dec. 31, 2015, with a minimum of 1 year of follow-up. Cases of SSC, including infections and wound dehiscence, were determined from patient records. Inpatient and outpatient hospital costs were determined 6 and 12 months after transplantation. We used the Kaplan–Meier product-limit method to determine the cumulative probability of SSCs and other outcomes. We evaluated risk factors and clinical outcomes using Cox proportional hazard ratios. Linear regression models were used to study the effect of SSCs on graft function. Results: The incidence rate of SSCs within 30 days after transplantation was 4.19 per 100 person-months. The cumulative probability of developing an SSC within 30 days after transplantation was 4.13% (95% confidence interval [CI] 3.23%–5.28%). Increased recipient body mass index (BMI) (hazard ratio [HR] 1.07, 95% CI 1.02–1.11), longer cold ischemic time (HR 1.05, 95% CI 1.01–1.09) and transplantation in 2010–2012 versus 2005–2009 (HR 2.20, 95% CI 1.19–4.04) were risk factors for SSC development. In multivariable stepwise Cox proportional hazard models, SSC was a significant risk factor for death-censored graft failure (HR 3.08, 95% CI 1.60–5.90) and total graft failure (HR 2.09, 95% CI 1.32–3.32). Cumulative median hospital costs were $2238.46 greater for patients with an SSC than for those without. Conclusion: Increased BMI, longer cold ischemic time and the 2010–2012 transplantation period predisposed to SSCs. The development of SSCs was associated with a higher risk of graft failure. Strategies to minimize SSCs may improve outcomes after kidney transplantation and reduce costs.

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Section: Discussionmentioning

confidence: 99%