Incidentally Discovered Persistent Müllerian Duct Syndrome in a 45-year-old male presenting with germ cell tumor and bilateral cryptorchidism: A rare case report and review of the literature

Harbi, Turki Z. Al; Azzam, Kareem Ayman; Azzam, Ayman; Amin, Tarek; Bakshi, Nasir

doi:10.1016/j.ijscr.2018.02.002

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Most of the patients are infertile (neither of our 2 reported patients gave birth) , and the ectopic testicles of some patients can become malignant, which seriously affects the physical and mental health of the patients. [3] There are many explanations for the causes of ectopic testes. The first explanation is that normal male testicles originate from different genitel ridge, and if 2 testes originate from the same genitel ridge, it may lead to ectopic testes.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Most patients with TTE present as children, however, in some areas, many patients are adults, and they often see a doctor with infertility, inguinal hernia or malignant tumor instead of TTE. [ 3 , 34 ] For children over 10 years old and adults with TTE, orchiectomy on the affected side is generally advocated because the ectopic testis has been in high temperature environment for a long time and the risk of malignant transformation has increased significantly. [ 35 , 36 ] Both of the patients we reported are adults.…”

Section: Discussionmentioning

confidence: 99%

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Misdiagnosis and mistreatment of transverse testicular ectopia-two case report and review of literature

Yang,

Xie,

Wang

2023

Medicine

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Rationale: Transverse testicular ectopia (TTE) is a rare congenital malformation with a high rate of misdiagnosis and mistreatment before operation, which cannot be diagnosed even during operation due to lack of knowledge. Patient concerns: Two patients with ectopic testes who were misdiagnosed as right inguinal hernia for the first time and underwent surgery. The “ovary” and “testicle” like structures was seen in the right inguinal region during the first operation. After being transferred to our hospital for laparoscopic surgery, it was found that the left spermatic cord and testis were transversely transverted to the right, the left testis was fixed at the right inner ring, and agglomerated soft tissue could be seen in the right inguinal canal, which was suspected to be Muller tube. Diagnoses: Based on preoperative images and intraoperative findings, both cases were diagnosed with Transverse testicular ectopia (TTE). The postoperative pathology report for the second patient revealed the presence of an in situ spermatogenic cell tumor in the ectopic testis. Interventions: Preperitoneal tension-free repair of right inguinal hernia and resection of left cryptorchidism were performed on the 2 patients. Outcomes: Postoperative pathology of the first patient confirmed that the resected specimens contained tubal-like and uterine-like structures. The postoperative pathology of the second patient showed that the resected tissue consists of immature testis, epididymis, uterus and seminal vesicle glands, in which an in situ spermatogenic tumor could be seen in the testicular tissue. Postoperative diagnosis: left transversal testicular ectopia and right indirect inguinal hernia. Lessons: The clinical misdiagnosis and mistreatment rate of TTE is very high. Once the patients with cryptorchidism complicated with inguinal hernia are found in clinic, the possibility of the disease must be considered. For the patients whose cryptorchidism does not descend into the ipsilateral scrotum and it is difficult to diagnose, laparoscopy can be used for both diagnosis and treatment. If a patient has both inguinal hernia and cryptorchidism, it is crucial to rule out a diagnosis of TTE to prevent misdiagnosis and inappropriate treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Misdiagnosis and mistreatment of transverse testicular ectopia-two case report and review of literature

Yang,

Xie,

Wang

2023

Medicine

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“…Al Harbi et al reported a case in which a 45-year-old patient who presented with an abdominal mass and empty scrotum was diagnosed with PMDS during abdominal exploration [ 9 ]. Interestingly, they started neoadjuvant BEP chemotherapy without a tissue diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Bilateral intra-abdominal testicular tumor: Case report

Sandıkçı

Çimen

Imamoğlu

et al. 2018

International Journal of Surgery Case Reports

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HighlightsRecognition of a retroperitoneal solid mass in an adult male must be considered as a `sign` and a testicular tumor should be sought.Although very rare, bilateral intra-abdominal testes may lead to bilateral testicular tumors.Patients with bilateral intra-abdominal testicular tumors necessitate a multi-disciplinary approach.Decisions regarding sperm banking and testosterone replacement therapy should be given by an individualized approach.Since there are no guidelines, guidance should be taken from published case reports.

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Disorders of Sexual Development, Persistent Mullerian Duct Syndrome

Nistal¹,

González‐Peramato²

2020

Encyclopedia of Pathology

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Incidentally Discovered Persistent Müllerian Duct Syndrome in a 45-year-old male presenting with germ cell tumor and bilateral cryptorchidism: A rare case report and review of the literature

Cited by 6 publications

References 12 publications

Misdiagnosis and mistreatment of transverse testicular ectopia-two case report and review of literature

Misdiagnosis and mistreatment of transverse testicular ectopia-two case report and review of literature

Bilateral intra-abdominal testicular tumor: Case report

Disorders of Sexual Development, Persistent Mullerian Duct Syndrome

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