ObjectiveAnomalous origin of coronary artery is uncommon. The taxonomies of anomalous
origin of coronary artery are inconsistent and complex. Conceptual and therapeutic
debates remain. The aim of the present study is to reappraise the concept of
anomalous origin of coronary artery and to discuss the potential hazards and
treatment rationale of this anomaly on basis of literature review.MethodsA comprehensive literature review was made in terms of the taxonomies including
“simple”, “multiple” and “complex” types of anomalous origin of coronary
artery.ResultsAnomalous origin of coronary artery can be simply categorized according to the
ectopically originated coronary artery. There are a couple of complex anatomical
variants: “multiple” type, involving more than one coronary artery or branch,
which can be subdivided into 2 subtypes, A) more than one coronary arteries or
branches arising from one place; and B) two coronary arteries/branches arising
from separate ectopic sites; and “complex” type, associated with acquired heart
disease, or congenital heart defects.ConclusionSudden cardiac death in anomalous origin of coronary artery is associated with the
anatomical features including abnormal coursing, acute angle take-off and ostial
abnormalities. Atherosclerosis is prone to be in the right-sided ectopic and
retroaortic coursing coronary artery. Surgical treatment is a definitive therapy.
Simple coronary artery bypass grafting is not recommended due to the potential
hazards of coronary steal phenomenon and poor patency of mammary arterial grafts,
and modified maneuvers such as coronary ostial reimplantation, impinged coronary
segment unroofing and coronary stent deployment are advocated instead.