Incidental MRI Findings of Acute Gadolinium Hypersensitivity

Amene, Chiazo; Yeh-Nayre, Lanipua; Dory, Christopher E.; Crawford, John R.

doi:10.1159/000338631

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Some groups have shifted to other types of materials in order to completely avoid gadolinium and its possible toxicity, as Gd 3+ is known to be toxic to patients with severe kidney disease as mentioned (leading to the devastating disorder NSF), some patients may be allergic, and there is evidence that Gd 3+ could cause brain hypersensitivity and neuronal cell death . Most of these other T1 imaging agents are nanomaterials.…”

Section: Imageable Nanomaterialsmentioning

confidence: 99%

“…118 Notably, Mn 2+ ions can also serve as the dopant or matrix component in upconversion nanomaterials rather than Gd 3+ , providing T1 contrast (see section 2.4.1 for upconversion nanomaterials). 91 Some groups have shifted to other types of materials in order to completely avoid gadolinium and its possible toxicity, as Gd 3+ is known to be toxic to patients with severe kidney disease as mentioned (leading to the devastating disorder NSF), 119 some patients may be allergic, 120 and there is evidence that Gd 3+ could cause brain hypersensitivity and neuronal cell death. 121 Most of these other T1 imaging agents are nanomaterials.…”

Section: Magnetic Nanomaterialsmentioning

confidence: 99%

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Nanomaterials for In Vivo Imaging

Gambhir²

2017

Chem. Rev.

920

718

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In vivo imaging, which enables us to peer deeply within living subjects, is producing tremendous opportunities both for clinical diagnostics and as a research tool. Contrast material is often required to clearly visualize the functional architecture of physiological structures. Recent advances in nanomaterials are becoming pivotal to generate the high-resolution, high-contrast images needed for accurate, precision diagnostics. Nanomaterials are playing major roles in imaging by delivering large imaging payloads, yielding improved sensitivity, multiplexing capacity, and modularity of design. Indeed, for several imaging modalities, nanomaterials are now not simply ancillary contrast entities, but are instead the original and sole source of image signal that make possible the modality's existence. We address the physicochemical makeup/design of nanomaterials through the lens of the physical properties that produce contrast signal for the cognate imaging modality-we stratify nanomaterials on the basis of their (i) magnetic, (ii) optical, (iii) acoustic, and/or (iv) nuclear properties. We evaluate them for their ability to provide relevant information under preclinical and clinical circumstances, their in vivo safety profiles (which are being incorporated into their chemical design), their modularity in being fused to create multimodal nanomaterials (spanning multiple different physical imaging modalities and therapeutic/theranostic capabilities), their key properties, and critically their likelihood to be clinically translated.

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Section: Imageable Nanomaterialsmentioning

confidence: 99%

Section: Magnetic Nanomaterialsmentioning

confidence: 99%

Nanomaterials for In Vivo Imaging

Gambhir²

2017

Chem. Rev.

920

718

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“…Despite, the positive attributes associated with nanoparticles and MRI, there still exist some limitations with using Gd 3+ as a contrast agent. This includes report of Gd 3+ linked to brain hypersensitivity and neural toxicity apoptosis, further complication in PAD patients with kidney diseases, and reactions for some patients . It should be noted that scientists are taking various measures to overcome these challenges by fabricating manganese (Mn 2+ )‐based NPs, which have been found to be more biocompatible than Gd 3+ for in vivo detection and result in minimal renal failure .…”

Section: Application Of Nanoparticles For Pad Detectionmentioning

confidence: 99%

Nanoparticles for Detection and Treatment of Peripheral Arterial Disease

Noukeu

Wolf

Yuan

et al. 2018

Small

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Peripheral arterial disease (PAD) is defined as a slow, progressive disorder of the lower extremity arterial vessels characterized by chronic narrowing that often results in occlusion and is associated with loss of functional capacity. Although the PAD occurrence rate is increasing in the elderly population, outcomes with current treatment strategies are suboptimal. Hence, there is an urgent need to develop new technologies that overcome limitations of traditional modalities for PAD detection and therapy. In this Review, the application of nanotechnology as a tool that bridges the gap in PAD diagnosis and therapy is in focus. Several materials including synthetic, natural, biodegradable, and biocompatible materials are used to develop nanoparticles for PAD diagnostic and/or therapeutic applications. Moreover, various recent research approaches are being explored to diagnose PAD through multimodality imaging with different nanoplatforms. Further efforts include targeted delivery of various therapeutic agents using nanostructures as carriers to treat PAD. Last, but not least, despite being a fairly new field, researchers are exploring the use of nanotheranostics for PAD detection and therapy.

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Breakthrough Hypersensitivity Reactions to Gadolinium-based Contrast Agents and Strategies to Decrease Subsequent Reaction Rates: A Systematic Review and Meta-Analysis

et al. 2020

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EVIDENCE-BASED PRACTICEG adolinium-based contrast agents (GBCAs) have been used clinically for decades and have an excellent safety record (1-3). Immediate hypersensitivity reactions to GB-CAs remain uncommon, estimated by meta-analysis to be approximately nine per 10 000 administrations, with severe reactions occurring in approximately five per 100 000 administrations (4). Limited studies have evaluated repeat GBCA administration in patients with a prior hypersensitivity reaction to a GBCA. The efficacy of corticosteroid premedication with or without antihistamines prior to repeat GBCA exposure remains unproven. Although commonly performed in clinical practice, the rationale for premedication prior to repeat GBCA administration is extrapolated from studies evaluating iodinated contrast media (5). Breakthrough reactions are immediate hypersensitivity reactions occurring despite appropriately dosed corticosteroid premedication. These reactions occur in up to one-third of patients in individual series that have studied GBCAs (6-8). Breakthrough reactions to GBCAs usually occur with the same severity as the original or index reaction, but escalation of breakthrough reaction severity to a GBCA has been reported (6-8). In patients with a prior severe hypersensitivity reaction to a GBCA, re-exposure to a GBCA (even with corticosteroid premedication) is contraindicated by the American College of Radiology (ACR) (9).

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Incidental MRI Findings of Acute Gadolinium Hypersensitivity

Cited by 3 publications

References 14 publications

Nanomaterials for In Vivo Imaging

Nanomaterials for In Vivo Imaging

Nanoparticles for Detection and Treatment of Peripheral Arterial Disease

Breakthrough Hypersensitivity Reactions to Gadolinium-based Contrast Agents and Strategies to Decrease Subsequent Reaction Rates: A Systematic Review and Meta-Analysis

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