“…Although we purposefully chose an initial service whose low value at a population level is well established in the literature, in some individual cases, the test may have resulted in care that improved health. 39 But on average, such cascades are likely to come at a cost to patients, clinicians, and payers [9][10][11][12] : in addition to the financial cost, patients might experience anxiety, risks associated with treatment, inconvenience, and opportunity costs owing to time spent on office visits or procedures 9,11,[40][41][42] or from the bur- 43,44 Meanwhile, physicians may feel distress, decision-making conflict, or burden from the added work of following up the initial abnormality. 10,11,40,42 We found that factors associated with cascades mirrored those associated with the low-value services themselves.…”