Incidental finding of subgemmal neurogenous plaque upon retrospective evaluation of oral lymphoepithelial cysts

Custódio, Marcos; Tobouti, Priscila Lie; Matuck, Bruno Fernandes; Sousa, Suzana Cantanhede Orsini Machado de

doi:10.1007/s10006-018-0726-6

Cited by 4 publications

(14 citation statements)

References 12 publications

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“…The clinical and demographic characteristics described in the present study are in agreement with previous data, that is , OLEC usually affects middle‐aged patients, appearing as a small, white, asymptomatic lesion on the tongue . Interestingly, 6.5% of the cases were diagnosed in individuals between 0 and 19 years of age, demonstrating that OLEC can affect pediatric patients as well.…”

Section: Discussionsupporting

confidence: 92%

“…Interestingly, 6.5% of the cases were diagnosed in individuals between 0 and 19 years of age, demonstrating that OLEC can affect pediatric patients as well. Previous reports provide conflicting results on sex predilection, but the present results lend support to female predominance.…”

Section: Discussionsupporting

confidence: 76%

“…The presence of subgemmal neurogenous plaque was reported by Custodio et al in 40% (6/15) of cases of OLEC located on the lateral border of the tongue. Pellicioli et al evaluated 28 cases of subgemmal neurogenous plaque, and only two (7.1%) were associated with OLEC.…”

Section: Discussionmentioning

confidence: 84%

“…The frequency of OLEC ranges from 16.4% to 30.99% of all non‐odontogenic developmental cysts . Due to its rarity, few studies have reported a large series of OLEC . Thus, although lymphocytic infiltrate is a prominent microscopic finding of OLEC, its cell composition has not been characterized and no previous studies have described the immunohistochemical features .…”

Section: Introductionmentioning

confidence: 99%

“…The posterior border of the tongue is also the preferred region of occurrence of subgemmal neurogenous plaque, which is an anatomic structure that can lead to discomfort, pain, and a burning sensation . However, the association between subgemmal neurogenous plaque and OLEC has been poorly explored, especially with regards to symptoms …”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and immunohistochemical features of the oral lymphoepithelial cyst: A multicenter study

Silva

Coelho

Couto

et al. 2019

J Oral Pathology Medicine

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Background Analyze the clinical, demographic, histopathological, and immunohistochemical features of oral lymphoepithelial cyst (OLEC). Methods Samples were retrospectively retrieved from five oral pathology services. Clinical and demographic data were collected from patient charts. Histopathological and immunohistochemical (CD3 and CD20) features were evaluated. Data analysis involved descriptive statistics and bivariate analyses (P ≤ .05). Results Seventy‐seven cases were found among a total of 146 150 specimens (0.05%). OLEC was predominantly diagnosed in females (70.1%). Mean patient age was 46.51 years. The lesions arose mainly on the lateral border of the tongue (40.3%), measured up to 1 cm (61.0%), and were asymptomatic (64.9%). Twenty‐four lesions (31.2%) were white. Forty‐one cases (53.2%) presented lymphocytic inflammatory infiltrate with no specific arrangement. The cystic lining was composed of a non‐keratinized stratified epithelium (59.7%) presenting hyperplasia (39.0%). Connection with the surface, epithelium was found in 23 cases (29.9%) and 31 (40.3%) cases had two or more cystic cavities. The lumen content was predominantly desquamated cells (48.1%). Subgemmal neurogenous plaque was found in 11/42 (26.2%) cases involving the tongue. CD20+ cells predominated in 36/63 cases (57.2%), and lymphocytic inflammatory infiltrate was not always continuous around the cystic cavity (52.4%). Conclusion Lymphoepithelial cyst is an uncommon lesion of the oral cavity. The present study offers the largest sample of OLEC for which clinical, demographic, histopathological, and immunohistochemical features were evaluated. The clinical and demographic findings were similar to those described in previous reports, but the microscopic analyses revealed interesting aspects of the cystic epithelium and the lymphocytic inflammatory infiltrate in OLEC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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