Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil

Cunha, John Lennon Silva; Roza, Ana Luiza Oliveira Corrêa; Cruz, Vitória Maria Sousa; Ribeiro, Jaqueline Lemes; Cavalcante, Israel Leal; Cavalcante, Roberta Barroso; Anbinder, Ana Lia; Abrahão, Aline Corrêa; Andrade, Bruno Augusto Benevenuto de; Romañach, Mário José; Pires, Fábio Ramôa; Santos‐Silva, Alan Roger; Lopes, Márcio Ajudarte; Vargas, Pablo Agustı́n; Soares, Ciro Dantas; Almeida, Oslei Paes de

doi:10.1007/s12105-021-01352-2

Cited by 9 publications

(10 citation statements)

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“…The majority of oral LEC were found to develop in the tongue and floor of the mouth (Table 4). In addition, similar to oral LEC presented, the literature also indicates that they are small lesions that generally do not exceed more than 2 cm [2][3][4][16][17][18][19][20][21][22].…”

Section: Resultsmentioning

confidence: 95%

“…The ratio of female:male for oral LECs is 1.33 (four females to three males), according to our cases (Table 3), and 0.9 (255:258) in the literature (Table 4). Though the majority of studies analyzed reveals female predilection [2,[16][17][18]20,21], one large series of cases from China [4] skewed the general trend, resulting in a slight male predilection. The preferred location of the oral LEC is the tongue and floor of the mouth (Table 4), where three (42%) of our cases occurred, followed by single lesion each at the palate, ventral tongue, and tonsillar fossa.…”

Section: Discussionmentioning

confidence: 99%

“…Thereafter, lymphoepithelial cysts that were associated with parotid glands and studies that dealt with clinico-pathological presentations of cysts other than LEC were excluded. Finally, a total of 10 articles that analyzed clinico-pathological presentations of at least 05 LEC were identified to present the literature review based presentations of LEC [2][3][4][16][17][18][19][20][21][22]. Four hundred and seventy-nine oral LEC were assessed in these studies.…”

Section: Methodsmentioning

confidence: 99%

“…[2][3][4][16][17][18][19][20][21][22] presents a summary of case series dealing with more than five LECs. Case reports dealing with single or two lesions amounting to 35 oral LEC are summarized under the Supplementary Materials Table S1, while the summary is included in Table4last row.…”

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confidence: 99%

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A Retrospective Clinico-Pathological Analysis with Review of Literature of Oral and Cervical Lympho-Epithelial Cysts from a Pathological Perspective

et al. 2022

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Oral and cervical lympho-epthelial cysts (LECs) are uncommon lesions with histopathological similarities. The aim of the study is to present clinico-pathological characteristics of oral and cervical LECs with a review of literature in order to create awareness on this uncommon entity. Eighteen new cases of oral and cervical LECs obtained from the archives of the University of Peradeniya and University of Geneva were used for the clinico-pathological analysis. The average age at diagnosis of 7 oral and 11 cervical LECs were 40 and 36 years, respectively. Both showed a female predilection (male:female ratio at 3:4 and 4:7, respectively). The only difference was found in the size of the lesions with oral LECs being significantly smaller than cervical LECs (0.9 cm vs. 4.6 cm). LECs may clinically resemble neoplasms (4/18), including malignancies (1/11 in the present series). None of the 18 LECs recurred following surgical removal. The literature-review-based analysis of 514 oral LECs confirms that the lesions are observed predominantly in adults in 4th–5th decades of life and are relatively small lesions of less than 2 cm in diameter. Oral LECs were found to occur predominantly in the tongue and floor of the mouth, similar to 88% of lesions in literature. In conclusion, oral and cervical LECs are two histologically similar cysts that occur in two distinct sites. The literature review supports the information observed in our study with respect to age of occurrence, site predilections, and size. Cervical LECs, particularly the ones that occur in the parotid region, may require further investigations to exclude BLEL of parotid gland, which occur in HIV infected patients.

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Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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A Retrospective Clinico-Pathological Analysis with Review of Literature of Oral and Cervical Lympho-Epithelial Cysts from a Pathological Perspective

et al. 2022

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“…All three conditions can present as solitary, asymptomatic, mucosa-colored, sessile, or pedunculated nodule, but only mucocele predominates at a younger age. [3][4][5] Mucocele, even if infrequent on the dorsum of the tongue, should be considered a differential diagnosis of asymptomatic, slow-growing, nodular lesions in the tongue's posterior region, as its occurrence has already been shown in a few cases, usually with greater frequency in the oral cavity and followed by lymphoepithelial cysts or granular cell tumors. An evaluation of the clinical aspects should be considered for decision-making on the treatment of nodular lesions on the tongue, whereas a biopsy, which tends to be the treatment itself, followed by histopathological analysis, is essential for making a proper diagnosis.…”

Section: Follow-up and Outcomementioning

confidence: 99%