Incidental Case of Relapsing Polychondritis Detected by 18F-FDG PET/CT

Kaida, Hayato; Ishii, Kazunari; Hanada, Soichiro; Tohda, Yuji; Murakami, Takamichi

doi:10.1097/rlu.0000000000001890

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Several studies have reported FDG uptake in diseases involving smaller arteries such as polyarteritis nodosa, 76 86 Wegener's granulomatosis, 87 Churg-Strauss syndrome, 88 or relapsing polychondritis. 89 90 91 Furthermore, FDG PET/CT may be able to differentiate between giant cell arteritis, Takayasu arteritis, and polyarteritis nodosa. 76 …”

Section: Aortitismentioning

confidence: 99%

Role of PET/CT in the Evaluation of Aortic Disease

Kim

Song

2018

Chonnam Med J

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Positron emission tomography (PET) /computed tomography (CT) has been established as a standard imaging modality in the evaluation of malignancy. Although PET/CT has played a major role in the management of oncology patients, its clinical use has also increased for various disorders other than malignancy. Growing evidence shows that PET/CT images have many advantages in aortic disease as well. This review article addresses the potential role of PET/CT in diseases involving the aorta, emphasizing its usefulness with regard to acute thoracic aortic syndromes, aortic aneurysm, atherosclerotic lesions, aortitis and aortic tumors.

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Section: Aortitismentioning

confidence: 99%

Role of PET/CT in the Evaluation of Aortic Disease

Kim

Song

2018

Chonnam Med J

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“…However, the majority of RP patients with airway involvement were misdiagnosed at their rst visit with a median time of delay to diagnosis of up to more than 10 years [1,4,5] . Our early studies [6][7][8] , along with other previous case reports or sporadic cases have shown that 18F-uorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT, hereafter termed PET/CT) with its semiquantitative parameter SUV max may be a helpful tool in aiding in the diagnosis and for therapeutic response monitoring [9][10][11][12][13][14][15] , with typical imaging characteristics of FDG uptake in the laryngo-tracheo-bronchial tree, often symmetrically.…”

Section: Introductionmentioning

confidence: 99%

F-18 FDG PET/CT in Relapsing Polychondritis Patients with Initial Respirotory Symptoms: Imaging Features and Association with Pulmonary Function and Disease Activity

Hou

Jin-ling

et al. 2022

Preprint

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Background: To summarize F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging features of relapsing polychondritis (RP) and to evaluate the feasibility of imaging parameters in the estimation of pulmonary function and disease activity in a cohort of RP patients with airway involvement.Methods: Thirty RP patients with respiratory symptoms who underwent PET/CT scans before corticosteroid treatment were included. Six patients underwent another post-therapeutic PET/CT scan. Imaging features were described by consensus, and FDG uptake values (SUVmax, PET FDG Burden Score (PETFBS) and PETCTindex) either for global cartilages or for the airway were calculated to correlate with clinical symptoms, pulmonary functional parameters and serological inflammatory markers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).Results: Laryngo-tracheo-bronchial involvement was detected by PET/CT for all patients with increased FDG uptake in 28/30 patients. The incidence of positive PET was higher in segments with wall thickening (52.68% vs. 15.48%) but was not associated with calcification or stenosis. A total of 46.7% (14/30) of patients presented with sole respiratory symptoms, while PET/CT revealed additional abnormalities in addition to laryngo-tracheo-bronchia. FDG uptake values negatively correlated with disease duration but not with fever. All FDG uptake values showed a positive correlation with FEV1/FVC, with the highest coefficient for SUVmax in the airway (rs =0.628). CRP and ESR were negatively correlated with PETFBS and PETCTindex but not with SUVmax. The largest Spearman correlation coefficient resulted in PETFBS in the airway (rs =0.67). Re-examination PET/CT in 6 patients revealed partial therapeutic response (n = 4), stable disease (n = 1) and progressive disease (n = 1).Conclusion: PET/CT is a valuable tool for assessing RP with airway involvement, especially for patients who present with sole respiratory symptoms. SUVmax and PETFBS have distinct advantages in the clinical evaluation of RP with respect to pulmonary function and disease activity.

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