Role of PET/CT in the Evaluation of Aortic Disease

Kim, Jahae; Song, Ho‐Chun

doi:10.4068/cmj.2018.54.3.143

Cited by 23 publications

(11 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PET scans highlight areas of increased metabolic activity. 38 Recent literature has suggested that PET/CT may allow visualization of inflammation seen in aortic pathology. This could potentially be used as a marker of progression/ instability in some PAUs and thus may be valuable for surveillance in selected patients.…”

Section: Discussionmentioning

confidence: 99%

The Management of Patients With Penetrating Aortic Ulcers: A Systematic Review

Pandey

Sharma

2021

Vasc Endovascular Surg

View full text Add to dashboard Cite

Background: Penetrating aortic ulcers (PAUs) are an entity within acute aortic syndrome. They often remain undiagnosed and are found incidentally or when they become symptomatic. Management is currently guided by clinical judgment. This review aims to identify indications for treatment and inform management. Methods: We searched PubMed for studies on the management of PAUs. The outcome measures were mortality, progression and resolution of symptoms. Results: This review incorporates 27 studies involving 1356 patients with PAU. Data was available regarding symptoms for 1213 patients (494 symptomatic, 719 asymptomatic). Overall late mortality for PAUs was found to be higher than 30-day mortality. Early mortality was higher for symptomatic patients as compared to those with asymptomatic PAUs. Early mortality was lowest for PAUs treated with endovascular interventions (5%), followed by PAUs managed medically and highest following open surgical management. Indications for treatment included symptoms, progression/instability, aortic diameter >5 cm, concomitant aortic pathology or pleural effusion. 13% of patients managed conservatively at initial presentation demonstrated progression and were considered for intervention subsequently. 9% of patients required reintervention after initial endovascular surgery. Conclusion: Endovascular treatment, if anatomically suitable, should be considered as first line treatment for symptomatic PAUs. Patients with asymptomatic PAUs, if associated with high-risk features such as PAU diameter >20 mm, PAU depth >10 mm, aortic diameter >42 mm, concomitant pathology, morphological change or an infective etiology, should also be considered for intervention. Small asymptomatic PAUs with no high-risk features may be managed conservatively but must undergo regular surveillance.

show abstract

Section: Discussionmentioning

confidence: 99%

The Management of Patients With Penetrating Aortic Ulcers: A Systematic Review

Pandey

Sharma

2021

Vasc Endovascular Surg

View full text Add to dashboard Cite

show abstract

“…This might indicate that elasticity measurements of the ascending aorta are impeded by nonoptimal diagnostic power to determine these adverse structural changes within the aortic vessel wall of individual patients with TS. If that is the case, hopefully new imaging developments such as nuclear imaging 21 or computational fluid dynamics 22 will help to noninvasively visualize the changes in the aortic wall or the abnormal blood flow as a result of abnormal aortic wall behavior. Another reason for our nonsignificantly different ascending aortic distensibility between women with and without TS might be the limited number of participants.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Aortic Wall Properties in Women with Turner Syndrome

et al. 2020

View full text Add to dashboard Cite

Background Turner syndrome (TS) is associated with aortic dilatation and dissection, but the underlying process is unclear. The aim of this study was to investigate the elastic properties and composition of the aortic wall in women with TS. Methods In this cross-sectional study, 52 women with TS aged 35 ± 13 years (50% monosomy, 12 with bicuspid aortic valve [BAV] and 4 with coarctation) were investigated using carotid-femoral pulse wave velocity (CF-PWV) by echocardiography and ascending aortic distensibility (AAD) and aortic arch pulse wave velocity (AA-PWV) by magnetic resonance imaging (MRI). As control group, 13 women with BAV without TS and 48 healthy patients were included. Results Women with TS showed a higher AA-PWV (β = 1.08, confidence interval [CI]: 0.54–1.62) after correcting for age and comorbidities compared with controls. We found no significant difference in AAD and CF-PWV. In women with TS, the presence of BAV, coarctation of the aorta, or monosomy (45, X) was not associated with aortic stiffness. In addition, aortic tissue samples were investigated with routine and immunohistochemical stains in five additional women with TS who were operated. The tissue showed more compact smooth muscle cell layers with abnormal deposition and structure of elastin and diminished or absent expression of contractile proteins desmin, actin, and caldesmon, as well as the progesterone receptor. Conclusion Both aortic arch stiffness measurements on MRI and histomorphological changes point toward an inherent abnormal thoracic aortic wall in women with TS.

show abstract

“…This hypermetabolism is considered as a marker of instability, of higher risk of rupture and embolization. Novel PET tracers, which are designed to track active calcification, inflammation, hypoxia, or neoangiogenesis, may be potential markers for plaque rupture and cardiovascular risk ( 49 ).…”

Section: Detection Of Aaamentioning

confidence: 99%

Aortic Sources of Embolism

et al. 2021

View full text Add to dashboard Cite

Aortic arch atheroma is a frequent finding in ischemic stroke patients. Its role as a source of cerebral emboli or a marker of atherosclerosis is unclear. Transesophageal echography is considered the gold standard for its detection, whereas computed tomography angiography is a good alternative; magnetic resonance and positron emission tomography could be proposed to better analyze plaque vulnerability. Despite the interest in this condition, the optimal antithrombotic treatment remains uncertain, while intensive lipid-lowering therapy should be recommended. This review aims to offer guidance on patients with aortic arch atheroma, about its causal role in stroke, diagnosis, and treatment based on current available evidence.

show abstract

Role of PET/CT in the Evaluation of Aortic Disease

Cited by 23 publications

References 99 publications

The Management of Patients With Penetrating Aortic Ulcers: A Systematic Review

The Management of Patients With Penetrating Aortic Ulcers: A Systematic Review

Abnormal Aortic Wall Properties in Women with Turner Syndrome

Aortic Sources of Embolism

Contact Info

Product

Resources

About