Incident Hepatitis C Virus Infection in Men Who Have Sex With Men: A Prospective Cohort Analysis, 1984-2011

Witt, Mallory D.; Seaberg, Eric C.; Darilay, Annie; Young, Stephen; Badri, Sheila; Rinaldo, Charles R.; Jacobson, Lisa P.; Detels, Roger; Thio, Chloe L.

doi:10.1093/cid/cit197

Cited by 121 publications

(121 citation statements)

References 22 publications

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“…[34][35][36][37][38] Similar to crosssectional studies, CAI 32,37,39 and a history of syphilis 32,37 were also reported as risk factors for incident HCV infection. However, the association with CAI was only significant in non-IDU in one Swiss clinic-based study of 1543 HIV-positive men.…”

Section: Other Risk Factors In Addition To Injecting Drug Usementioning

confidence: 57%

“…31 The large-scale Multicenter AIDS Cohort in the US reported an HCV incidence of 1.6 per 1000 person-years in non-IDUs, and this was significantly higher in previous and current IDUs (6.9 and 25.8 per 1000 person-years, respectively). 32 In Melbourne, Australia, 620 HIV-positive men were followed up for a total of 4359 person-years, and the incidence of HCV was significantly higher in IDUs (hazard ratio = 8.7, 95% CI 4.6-16.6). 33 …”

Section: Injecting Drug Use As a Risk Factormentioning

confidence: 99%

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Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

2017

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Abstract.A systematic review was performed on the evidence of sexual transmission of hepatitis C virus (HCV) in gay and bisexual men (GBM). Studies conducted in industrialised countries and published in English from 2000 to 2015 with data on HCV in GBM were included. Pooled estimates of prevalence and incidence of HCV infection were stratified by study settings and participants' HIV status using random effect models. Case-series reports were summarised descriptively. Of the 38 cross-sectional studies, the pooled HCV prevalence was substantially higher in HIV-positive men (8.3%, 95% CI: 6.7-9.9) than in HIV-negative men (1.5%, 95% CI 0.8-2.1), and higher in those who reported injecting drug use (34.8%, 95% CI 26.9-42.7) than in those who did not (3.5%, 95% CI 2.4-4.5). Of the 16 longitudinal studies, the pooled HCV incidence was markedly higher in clinic-based (7.0 per 1000 person-years, 95% CI 4.6-9.5) than in community-based (1.4 per 1000 person-years, 95% CI 0.7-2.1) studies, and in HIV-positive men (6.4 per 1000 person-years, 95% CI 4.6-8.1) than in HIV-negative men (0.4 per 1000 person-years, 95% CI 0-0.9). Since the early 2000s, 15 case-series reports increasingly pointed to the importance of sexual transmission of HCV in mainly HIV-positive men. Injecting drug use remained the major transmission route of HCV in GBM. Receptive condomless intercourse and concurrent ulcerative sexually transmissible infections are likely drivers that facilitated HCV sexual transmission in HIV-positive men. HCV incidence remains very low in HIV-negative GBM.

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Section: Other Risk Factors In Addition To Injecting Drug Usementioning

confidence: 57%

Section: Injecting Drug Use As a Risk Factormentioning

confidence: 99%

Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

2017

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“…A prospective US cohort study demonstrated an association of incident HCV with higher numbers of receptive unprotected anal intercourse partners, as well as injecting drug use and HIVpositive status. HCV incidence was 0.5 per 1000 PY in HIV-negative MSM compared to 4.2 per 1000 PY in HIV-positive MSM (171). In a systematic review of 38 cross-sectional studies, the pooled HCV prevalence was found to be significantly higher in HIV-positive men (8.3%, 95% CI: 6.7-9.9) than in HIVnegative men (1.5%, 95% CI 0.8-2.1).…”

Section: Hepatitis Cmentioning

confidence: 88%

2016 United Kingdom national guideline on the sexual health care of men who have sex with men

et al. 2018

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“…Nonetheless, HCV incidence was only 0.5 per 1000 PY in HIV-negative MSM compared with 4.2 per 1000 PY in HIV-positive MSM. 105 Among HIVpositive MSM in Australia and overseas, there are recent data supporting sexual or permucosal HCV transmission. 101,106,107 In a recent Australian study, 60% of HIV-positive Australian MSM with acute HCV did not report an IDU history.…”

Section: Hepatitis C Virusmentioning

confidence: 99%

Australian sexually transmissible infection and HIV testing guidelines for asymptomatic men who have sex with men 2014: a review of the evidence

et al. 2014

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Abstract.Men who have sex with men (MSM) in Australia and overseas are disproportionately affected by sexually transmissible infections (STIs), including HIV. Many STIs are asymptomatic, so regular testing and management of asymptomatic MSM remains an important component of effective control. We reviewed articles from January 2009-May 2013 to inform the 2014 update of the 2010 Australian testing guidelines for asymptomatic MSM. Key changes include: a recommendation for pharyngeal chlamydia (Chlamydia trachomatis) testing, use of nucleic acid amplification tests alone for gonorrhoea (Neisseria gonorrhoeae) testing (without gonococcal culture), more frequent (up to four times a year) gonorrhoea and chlamydia testing in sexually active HIV-positive MSM, time required since last void for chlamydia first-void urine collection specified at 20 min, urethral meatal swab as an alternative to first-void urine for urethral chlamydia testing, and the use of electronic reminders to increase STI and HIV retesting rates among MSM.

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Incident Hepatitis C Virus Infection in Men Who Have Sex With Men: A Prospective Cohort Analysis, 1984-2011

Abstract: The spread of HCV among both HIV-infected and -uninfected MSM in the United States has been ongoing since the beginning of the HIV epidemic. In HIV-infected men with <500 CD4(+) T cells, the HCV incidence rate was inversely proportional to CD4 T-cell count.

Cited by 121 publications

References 22 publications

Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

2016 United Kingdom national guideline on the sexual health care of men who have sex with men

Australian sexually transmissible infection and HIV testing guidelines for asymptomatic men who have sex with men 2014: a review of the evidence

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