Incidencia de demencia de inicio precoz en Mar de Plata

Abstract

This study, conducted in a closed population, yielded an EOD incidence rate of 11 per 100 000 inhabitants/year. To the best of our knowledge, this is the first prospective epidemiological study in Argentina and in Latin America.

Young-onset dementia and the need for specialist care: a national and international perspective

“…For example, the Harvey and Ikejima studies identified a population prevalence of 54.0/100,000 and 51.7/100,000, respectively, for the 30-65 year age group but by contrast, a catchment area study conducted in Sydney produced a prevalence rate of 68.2/100,000 (95% confidence interval (CI): 54.9-83.4) (Withall, Draper, Seeher, & Brodaty, 2014). An Argentinian study using data from a 'closed-hospital population' with data extrapolated to the general population using national census data demonstrated an incidence rate of 11/100,000 (Sanchez-Abraham et al, 2015). The only UK study examining the incidence for all cases of primary dementia for the age range 45-64 years estimated it to be 11.5 cases per 100,000 person-years (95% CI 8.6-15.0, (Mercy, Hodges, Dawson, Barker, & Brayne, 2008)).…”

Controlled population-based comparative study of USA and international adult [55-74] neurological deaths 1989-2014

“…There are confirmed rises of ALS from a number of Western clinical studies1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 25 as well as small increases in Asian and Latin American countries 18, 19…”

“…This was followed‐up in a second international study taking the results to 2010. The latter analysis used the later baseline years of 1989‐91, which confirmed the earlier onset of neurological morbidity and that neurological deaths continued to increase in the majority of the countries reviewed 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12. Rises in USA the over‐75s neurological deaths were considerable as the USA had significantly greater increases than fourteen of the other twenty nations, with threefold rises in American men and a fivefold increase in women in just 21 years 8.…”

“…Moreover, compared with the earlier analyses between 1989 and 2010 where there were notable rises in males in six countries and in four countries for females, by 2014 there had been rises of equivalent to >10% in twelve countries for men and in eleven countries for females. A Gompertzian perspective also ignores rises in early onset dementia (EOD) reported in many countries 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 19, 20, 22, 25. For example, one found 29% of their cohort were aged under 65 years, which 30 years before would have been considered extraordinary 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 19, 20, 22, 25.…”

“…However, the diagnostic issue has limited impact as it is mortality rates that are measured not separate diagnostic categories, and at this point, there is little evidence of diagnostic uncertainty as the primary cause of death is categorized as being due to a neurological condition 1, 5, 6, 7, 8. Moreover, the Gompertzian position appears to have ignored the marked changes between the sexes and in different countries 1, 5, 6, 7, 8, 9, 10, 11. Crucially, the Gompertzian hypothesis does not account for the substantial rise in early onset dementia reported in many Western countries 12, 13, 18, 19, 20, 21, 22…”