Incidence and characteristics of uncommon dementia subtypes: Results from 10 years of clinical surveillance by the Registry of Dementia of Girona

Introduction: Reliable data on the incidence rates for young-onset dementia (YOD) are lacking, but are necessary for research on disease etiology and to raise awareness among health care professionals. Methods:We performed a systematic review and meta-analysis on population-based studies on the incidence of YOD, published between January 1, 1990 and February 1, 2022, according to Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines. Data were analyzed using random-effects meta-analyses. Results were age-standardized, and heterogeneity was assessed by subgroup analyses and meta-regression.Results: Sixty-one articles were included. Global age-standardized incidence rates increased from 0.17/100,000 in age 30 to 34 years, to 5.14/100,000 in age 60 to 64 years, giving a global total age-standardized incidence rate of 11 per 100,000 in age 30 to 64. This corresponds to 370,000 new YOD cases annually worldwide. Heterogeneity was high and meta-regression showed geographic location significantly influenced this heterogeneity.Discussion: This meta-analysis shows the current best estimate of YOD incidence. New prospective cohort studies are needed.

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“…Of these, 61 articles reported on the incidence of YOD and were included in this systematic review (eFigure A). 9,10,18–76 …”

Section: Resultsmentioning

confidence: 99%

Global incidence of young‐onset dementia: A systematic review and meta‐analysis

Hendriks

Peetoom

Bakker

et al. 2022

Alzheimer's & Dementia

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“…Data were extracted from the following sources: The Registry of Dementias of Girona (ReDeGi) registers demographic and clinical data of all the incident cases of dementia diagnosed in the neurology or geriatrics outpatient consultation offices, or in the memory clinics of the seven hospitals of the public health care system of the province of Girona (Catalonia, Spain). The methodological principles of the ReDeGi have been previously described [33][34][35][36]. ReDeGi records the origin of the dementia cases included.…”

Section: Origin Of the Datamentioning

confidence: 99%

A 14-Year Longitudinal Analysis of Healthcare Expenditure on Dementia and Related Factors (DEMENCOST Study)

Inoriza

Carreras

Coderch³

et al. 2023

JAD

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Background: The large number of dementia cases produces a great pressure on health and social care services, which requires efficient planning to meet the needs of patients through infrastructure, equipment, and financial, technical, and personal resources adjusted to their demands. Dementia analysis requires studies with a very precise patient characterization of both the disease and comorbidities present, and long-term follow-up of patients in clinical aspects and patterns of resource utilization and costs generated. Objective: To describe and quantify direct healthcare expenditure and its evolution from three years before and up to ten years after the diagnosis of dementia, compared to a matched group without dementia. Methods: Retrospective cohort design with follow-up from 6 to 14 years. We studied 996 people with dementia (PwD) and 2,998 controls matched for age, sex, and comorbidity. This paper adopts the provider’s perspective as the perspective of analysis and refers to the costs actually incurred in providing the services. Aggregate costs and components per patient per year were calculated and modelled. Results: Total health expenditure increases in PwD from the year of diagnosis and in each of the following 7 years, but not thereafter. Health status and mortality are factors explaining the evolution of direct costs. Dementia alone is not a statistically significant factor in explaining differences between groups. Conclusion: The incremental direct cost of dementia may not be as high or as long as studies with relatively short follow-up suggest. Dementia would have an impact on increasing disease burden and mortality.

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“…Demographic and clinical characteristics also differed, for example, non-AD neurodegenerative dementia and dementia due to multiple causes occurred mainly in men and those that were older. In contrast, women were predominantly represented in those with dementia associated with a mental health disorder, as a higher number of women had a history of depression or were referred from mental health service units (Calvó-Perxas et al, 2019).…”

Section: Disease Incidence and Patient Characteristicsmentioning

confidence: 99%

The Impact of Disease Registries on Advancing Knowledge and Understanding of Dementia Globally

Heikal

Salama

Richard³

et al. 2022

Front. Aging Neurosci.

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To help address the increasing challenges related to the provision of dementia care, dementia registries have emerged around the world as important tools to gain insights and a better understanding of the disease process. Dementia registries provide a valuable source of standardized data collected from a large number of patients. This review explores the published research relating to different dementia registries around the world and discusses how these registries have improved our knowledge and understanding of the incidence, prevalence, risk factors, mortality, diagnosis, and management of dementia. A number of the best-known dementia registries with high research output including SveDem, NACC, ReDeGi, CREDOS and PRODEM were selected to study the publication output based on their data, investigate the key findings of these registry-based studies. Registries data contributed to understanding many aspects of the disease including disease prevalence in specific areas, patient characteristics and how they differ in populations, mortality risks, as well as the disease risk factors. Registries data impacted the quality of patients’ lives through determining the best treatment strategy for a patient based on previous patient outcomes. In conclusion, registries have significantly advanced scientific knowledge and understanding of dementia and impacted policy, clinical practice care delivery.

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Incidence and characteristics of uncommon dementia subtypes: Results from 10 years of clinical surveillance by the Registry of Dementia of Girona

Cited by 7 publications

References 40 publications

Global incidence of young‐onset dementia: A systematic review and meta‐analysis

Global incidence of young‐onset dementia: A systematic review and meta‐analysis

A 14-Year Longitudinal Analysis of Healthcare Expenditure on Dementia and Related Factors (DEMENCOST Study)

The Impact of Disease Registries on Advancing Knowledge and Understanding of Dementia Globally

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