Incidence trends of keratinocytic skin cancers and melanoma in Israel 2006-11

Sella, Tal; Goren, Idan; Shalev, Varda; Shapira, Hagit; Zandbank, Judith; Rosenblum, Jared S.; Kimlin, Michael G.; Chodick, Gabriel

doi:10.1111/bjd.13213

Cited by 24 publications

(24 citation statements)

References 22 publications

(65 reference statements)

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“…5,21–24 For example, the state of Israel had the second highest incidence and mortality due to melanoma in the world; however, following prevention and detection efforts, its incidence rate dropped to 13th place for men and 20th place for women, whereas mortality dropped to eight and 10th place, respectively. 22,23,25 Furthermore, rates of melanoma in situ increased, indicating a higher awareness and increase in early detection. 22,25 Next, in an effort to improve waiting time after identification of a suspicious lesion, the United Kingdom implemented a “2-week” rule, according to which patients needed to see a specialist within 2 weeks of being referred by their general practitioner for any suspicion of cancer.…”

Section: Discussionmentioning

confidence: 99%

“…22,23,25 Furthermore, rates of melanoma in situ increased, indicating a higher awareness and increase in early detection. 22,25 Next, in an effort to improve waiting time after identification of a suspicious lesion, the United Kingdom implemented a “2-week” rule, according to which patients needed to see a specialist within 2 weeks of being referred by their general practitioner for any suspicion of cancer. Following implementation of this rule, detected melanomas were lower in stage and OS was significantly improved.…”

Section: Discussionmentioning

confidence: 99%

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Determination of the impact of melanoma surgical timing on survival using the National Cancer Database

Conic

Cabrera

Khorana

et al. 2018

Journal of the American Academy of Dermatology

103

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Background The ideal timing for melanoma treatment, predominantly surgery, remains undetermined. Patient concern for receiving immediate treatment often exceeds surgeon or hospital availability, requiring establishment of a safe window for melanoma surgery. Objective To assess the impact of time to definitive melanoma surgery on overall survival. Methods Patients with stage I to III cutaneous melanoma and with available time to definitive surgery and overall survival were identified by using the National Cancer Database (N = 153,218). The t test and chi-square test were used to compare variables. Cox regression was used for multivariate analysis. Results In a multivariate analysis of patients in all stages who were treated between 90 and 119 days after biopsy (hazard ratio [HR], 1.09; 95% confidence interval [CI], 1.01–1.18) and more than 119 days (HR, 1.12; 95% CI, 1.02–1.22) had a higher risk for mortality compared with those treated within 30 days of biopsy. In a subgroup analysis of stage I, higher mortality risk was found in patients treated within 30 to 59 days (HR, 1.05; 95% CI, 1.01–1.1), 60 to 89 days (HR, 1.16; 95% CI, 1.07–1.25), 90 to 119 days (HR, 1.29; 95% CI, 1.12–1.48), and more than 119 days after biopsy (HR, 1.41; 95% CI, 1.21–1.65). Surgical timing did not affect survival in stages II and III. Limitations Melanoma-specific survival was not available. Conclusion Expeditious treatment of stage I melanoma is associated with improved outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Determination of the impact of melanoma surgical timing on survival using the National Cancer Database

Conic

Cabrera

Khorana

et al. 2018

Journal of the American Academy of Dermatology

103

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“…The completeness of Israel National Cancer Registry data has been estimated as being 95% [13]. We used pathology reports to identify incident cases of BCC and SCC [14]. …”

Section: Methodsmentioning

confidence: 99%

Parkinson’s Disease, Melanoma, and Keratinocyte Carcinoma: A Population-Based Study

Lerman

Amichai

Weinstein³

et al. 2018

Neuroepidemiology

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Background: The association between Parkinson’s disease (PD) and melanoma is well recognized, but its relationship with non-melanoma skin cancers has not been studied in depth. Objective: To assess the relationship between PD, and risk of melanoma and keratinocyte carcinoma: squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Methods: This historical cohort study used the data of 1.2 million adult members of a large health organization between 2000 and 2015. Individuals who were diagnosed with PD anytime between 2000 and 2010 were retrospectively followed until 8/2016 for incidence of SCC, BCC, or melanoma identified from physician diagnoses and pathology reports. Results: The PD cohort included 7,727 patients (mean [SD] age = 69.9 [14.8 years]) among the 1,251,695 study population. During follow-up, a total of 4,553, 32,069, and 4,015 cases of BCC, SCC, and melanoma were identified in the study population respectively. Multivariable models revealed that older age, male sex, never smoking, and residence in southern Israel and actinic keratosis were associated with an increased risk of both BCC and SCC. PD patients in the age range 45–64 and 65–84 years at baseline had an OR of 2.11 (95% CI 1.40–3.18) and 1.52 (95% CI 1.21–1.91) for BCC respectively. Weak or no associations were calculated for melanoma or SCC. Conclusions: We report a positive relationship between PD and risk of BCC. These results should stimulate greater awareness on the part of healthcare providers to the increased risk of BCC in PD patients.

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“…[8][9][10] World literature reports were similar; both nonmelanoma skin cancers were most commonly diagnosed after age 70 years. [41][42][43][44][45] REP studies highlighted an increased likelihood of diagnosis of cutaneous malignant melanoma in Olmsted County in persons older than 60 years, with the highest reported incidence for women occurring in the 40-to 59-year-old age group in one study. 13,14 In the world literature, the highest incidence of malignant melanoma and melanoma in situ was in those aged 65 years and older.…”

Section: Skin Cancermentioning

confidence: 99%

“…13,14 In the world literature, the highest incidence of malignant melanoma and melanoma in situ was in those aged 65 years and older. [44][45][46][47][48][49][50][51] Of note, premalignant melanoma in a study in western Australia was more commonly diagnosed in men older than 80 years, whereas women were most commonly aged 40-49 years. 57 In Olmsted County, lentigo maligna was more commonly diagnosed in those aged 70 years and older.…”

Section: Skin Cancermentioning

confidence: 99%

Incidence of diseases primarily affecting the skin by age group: population‐based epidemiologic study in Olmsted County, Minnesota, and comparison with age‐specific incidence rates worldwide

2018

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Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, population-based epidemiologic studies have been performed to estimate the incidence of specific skin diseases over the past 50 years. In older persons (>65 years), nonmelanoma skin cancer, lentigo maligna, herpes zoster, delusional infestation, venous stasis syndrome, venous ulcer, and burning mouth syndrome were more commonly diagnosed. In those younger than 65 years, atypical nevi, psoriatic arthritis, pityriasis rosea, herpes progenitalis, genital warts, alopecia areata, hidradenitis suppurativa, infantile hemangioma, Behçet's disease, and sarcoidosis (isolated cutaneous, with sarcoidosis-specific cutaneous lesions and with erythema nodosum) had a higher incidence. Many of the incidence rates by age group of diseases primarily affecting the skin derived from the Rochester Epidemiology Project were similar to those reported elsewhere.

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Incidence trends of keratinocytic skin cancers and melanoma in Israel 2006-11

Abstract: The incidence of KC in Israel is high. The disparities in incidence trends between SCC, BCC and melanoma allude to their different aetiologies. These findings underscore the importance of continuous monitoring, education and prevention programmes in a growing high-risk population.

Cited by 24 publications

References 22 publications

Determination of the impact of melanoma surgical timing on survival using the National Cancer Database

Determination of the impact of melanoma surgical timing on survival using the National Cancer Database

Parkinson’s Disease, Melanoma, and Keratinocyte Carcinoma: A Population-Based Study

Incidence of diseases primarily affecting the skin by age group: population‐based epidemiologic study in Olmsted County, Minnesota, and comparison with age‐specific incidence rates worldwide

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