Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Baş, Ahmet Yağmur; Demirel, Nihal; Koç, Esin; Işık, Dilek Ulubaş; Hırfanoğlu, İbrahim Murat; Tunç, Turan

doi:10.1136/bjophthalmol-2017-311789

Cited by 128 publications

(159 citation statements)

References 21 publications

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“…Even so, the ROP with severe and advantage stages may result in blindness or poor sight even with treatment. GA, BW, and oxygen therapy are well-known major risk factors in the development of ROP [22] [23] [24]. In this study, the mean of the gestational week at birth, birth weight, and length of stay in incubator were lower in infants with ROP compared to the ones without it, significantly.…”

Section: Discussionmentioning

confidence: 45%

“…The study conducted in high-income countries have shown that babies born at ≥32 weeks are not at high risk for developing ROP and most babies born at >28 weeks who develop ROP have a mild disease that spontaneously regressed without any treatment [35]. The TR-ROP study showed comparable to those from other developing countries and showed that more mature and heavier babies were at risk for severe ROP [24] [36].…”

Section: Discussionmentioning

confidence: 93%

“…Uğurbaş et al suggest that the criteria in the United States and Britain have could be adapted to Turkey, and so decrease that the number of unnecessary fundus examinations [30]. Bas et al, in the multicentric study, showed that screening of infants with a GA ≤ 34 weeks or a BW < 1700 g appears to be appropriate in Turkey [24]. In our study, there were an average GA of 29 (range, 23 -35) weeks and average BW of 1180 (range, 490 -2850) grams in infants with ROP.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological and Clinical Features of the Preterms Followed-Up at Our Clinic in Turkey: A Study about 458 Infants

Akdogan¹,

Sabaner²,

Karabaş³

2018

OJOph

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Purpose: We aimed to evaluate 458 infants, who were followed up due to retinopathy of prematurity (ROP), demographically and epidemiologically. Methods: 458 infants with ROP, who were referred from our hospital's neonatal intensive care unit and from other health centers to our clinic for the staging and treatment between February 2016 and December 2017, were studied retrospectively. Design: Retrospective-observational study. Results: Of the 458 infants, 243 infants (53.06%) did not have ROP and they were at a mean of 32nd (26-35) gestational week, weighing a mean of 1700 (820-2830) gr. The remaining 215 (46.94%) infants were diagnosed with ROP at various stages and they were at a mean of 29th (23-35) gestational week, weighing a mean of 1180 (490-2850) gr. Of the infants without ROP, 116 (47.7%) were females and 127 (52.3%) were males. The mean duration of stay at the incubator was a mean of 16.5 (0-120) days and the mean duration of follow-up was a mean of 43 (40-56) weeks. 103 (40.2%) of them were breastfed only. Of the infants with ROP at various stages, 95 (44.2%) were females, and 120 (55.8%) were males. The mean duration of stay at the incubator was 42 (6-195) days, and the mean duration of follow-up was 48 (40-73) weeks. 43 (20.0%) of them were breastfed only. 32 (13.2%) infants without ROP were born of multi-fetal pregnancies. Only 1 of them was born as one of the triplets. Of the babies with ROP; 56 (26.04%) were born of multi-fetal pregnancies, 5 of them being triplets. The numerical values of the gestational week at birth and the birth weight, and the rates of breastfeeding were lower in infants with ROP compared to the ones without it (p < 0.001). However, their follow-up durations were longer (p < 0.001). There was observed a male predominance and multi-fetal pregnancies in the infants with ROP (respectively, p > 0.05, <0.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Epidemiological and Clinical Features of the Preterms Followed-Up at Our Clinic in Turkey: A Study about 458 Infants

Akdogan¹,

Sabaner²,

Karabaş³

2018

OJOph

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“…Çalışmamızın bulguları da (Evre 2/3 NEK hariç) bu sonuçları desteklemektedir. Prematürelerde mekanik ventilasyon ve oksijen destek süresi, RDS, BPD, İVK, haPDA, NEK, PR ve GNS riski yüksek olması beklenen bir durumdur(30,31).…”

unclassified

Çok Düşük Doğum Ağirlikli Yeni̇doğanlarda Konjeni̇tal Hi̇poti̇roi̇di̇ Ve Prematüre Reti̇nopati̇si̇ İli̇şki̇si̇ni̇n Araştirilmasi

Çakır

Tayman

Büyüktiryaki

2018

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Amaç: Prematüre retinopatisi (PR), çocukluk çağında körlüğe neden olabilen başlıca prematürelerin retinasında meydana gelen vazoproliferatif bir hastalıktır. Çalışmamızda çok düşük doğum ağırlıklı (ÇDDA) prematürelerde konjenital hipotiroidinin (KH) PR'si üzerine etkisi ve PR için risk faktörlerine bakılması amaçlanmıştır. Gereç ve Yöntem: Çalışma 51 aylık dönem boyunca yatan ÇDDA bebeklerde geriye dönük tıbbi kayıtların değerlendirilmesi neticesinde gerçekleştirildi. Hastalar KH tanısı ve lazer fotokoagülasyon tedavisi gerektiren PR olmasına göre gruplara ayrıldı. Conclusion: CH had no effect on ROP. However, other risks of prematurity on ROP were found to be more effective. In infants with ROP, sT4 was lower and TSH was higher. Since thyroid hormones have an effect on angiogenesis, further studies on the relation between ROP and thyroid hormones are warranted.

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“…[4] In a multicenter study conducted in our country, the findings showed that preterms with fewer than 34 gestational weeks and birth weight less than 1700 grams should be screened for ROP. [5] In the treatment of ROP, primarily ablation by laser photocoagulation (LFC) of the avascular retina is performed. [6] Thus, cells that produce vascular endothelial growth factor (VEGF) in the retina are destroyed.…”

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confidence: 99%

Evaluation of Treatment Models in the Treatment of Retinopathy of Prematurity

et al. 2018

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Objectives: This study aims to evaluate the treatment modalities applied for retinopathy of prematurity (ROP) and to determine the efficacy and results of treatment modalities. Methods: Premature babies, who needed treatment for ROP and followed-up in the Neonatal Intensive Care Unit (NICU) of our hospital or external centers, were retrospectively evaluated between January 2012 and January 2017. According to the criteria determined by the International ROP committee, the zones and stages of the cases were recorded. In this study, patients were evaluated in three groups. Group 1: plus disease with any stage in zone 1, group 2: plus disease in zone 2, together with stage 2 or 3, group 3: classified as aggressive posterior retinopathy (APROP). The birth weight, gestational age, treatment weeks and treatments that were administered were recorded. Regression in plus disease, macular dragging and retinal detachment did not develop were evaluated as successful treatment. Results: 1746 preterm babies were examined. 65 (3.7%) preterm babies were included in this study, 31 female and 34 male. 126 eyes of preterm babies were intervened. The mean birth weight was 1159 (535-2200) grams, and the mean gestational age was 28.4±2.5 (24-34) weeks. Group 1 had 33 eyes (26.1%), group 2 had 71 eyes (56.3%), and group 3 had 22 eyes (17.4%). 94 eyes (74.6%) were treated once, 26 eyes (20.6%) were treated twice, 6 eyes (4.8%) received treatment three times. The first treatment was applied at 36±2.4 (32-41) weeks. The first treatment was performed with intravitreal bevacizumab (IVB) in 75.8% of group 1 and 95.5% of group 3, and with diode laser photocoagulation (LPC) in 78.9% of group 2. There was a significant correlation between birth week and birth weight and first treatment week. Re-treatment was applied to 32,8% in LPC group and 19.2% in the IVB group due to recurrence. 5 eyes which were applied LPC+IVB did not need any re-treatment. Stage 4a retinal detachment developed in both eyes of 1 patient from group 1. Macular traction was developed in 2 eyes of 1 patient in group 2. After the treatments, success in 122 eyes (96.8%) was obtained. Conclusion: ROP can be controlled by convenient and effective treatment. Although conventional LPC is still the first treatment option for ROP, IVB alone or combination with LPC is a highly effective treatment option for zone 1 disease and APROP. IVB reduces the number of ROP treatments.

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Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Abstract: NCT02814929, Results.

Cited by 128 publications

References 21 publications

Epidemiological and Clinical Features of the Preterms Followed-Up at Our Clinic in Turkey: A Study about 458 Infants

Epidemiological and Clinical Features of the Preterms Followed-Up at Our Clinic in Turkey: A Study about 458 Infants

Çok Düşük Doğum Ağirlikli Yeni̇doğanlarda Konjeni̇tal Hi̇poti̇roi̇di̇ Ve Prematüre Reti̇nopati̇si̇ İli̇şki̇si̇ni̇n Araştirilmasi

Evaluation of Treatment Models in the Treatment of Retinopathy of Prematurity

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