Incidence, prognosis and predictors of heart failure after acute myocardial infarction

Melendo-Viu, María; Abu‐Assi, Emad; Manzano‐Fernández, Sergio; Flores-Blanco, Pedro J.; Cambronero-Sánchez, Francisco; Pérez, David Dobarro; Fernández, María Cespón; Galián, María José Sánchez; Molina, Miriam Gómez; Caneiro‐Queija, Berenice; Paz, Rafael Cobas; Pousa, Isabel Muñoz; Valdés, Mariano; Pascual-Figal, Domingo A.; Íñiguez‐Romo, Andrés

doi:10.1016/j.rccl.2019.08.001

Cited by 5 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 (26.3%) patients were hospitalized due to chronic HF (CHF) exacerbation and 112 (73.7%)-due to planned CHF evaluation. The median age was 57 (48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62) years. In the study population, 2% of the patients presented NYHA class I, 40.8% NYHA class II, 46.7% NYHA class III, and 10.5% NYHA class IV.…”

Section: Resultsmentioning

confidence: 99%

“…High BNP or NT-proBNP are well documented as connected with a worse prognosis in HF. They are predictors of more frequent hospitalizations [ 49 ], rehospitalizations [ 50 ], deaths [ 51 ], and more severe symptoms [ 52 ]. Higher BNP or NT-proBNP levels are associated independently with the worse overall and physical domain of QoL [ 47 , 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Clinical, Biochemical, and Echocardiographic Parameters on the Quality of Life in Patients with Heart Failure with Reduced Ejection Fraction

Kałużna‐Oleksy

Sawczak

Kukfisz

et al. 2021

IJERPH

View full text Add to dashboard Cite

Despite significant advances in HF diagnosis and treatment over the recent decades, patients still characterize poor long-term prognosis with many recurrent hospitalizations and reduced health-related quality of life (HRQoL). We aimed to check the potential relationship between clinical, biochemical, or echocardiographic parameters and HRQoL in patients with HF with reduced ejection fraction (HFrEF). We included 152 adult patients hospitalized due to chronic HFrEF. We used the WHOQoL-BREF questionnaire to assess HRQoL and GNRI to evaluate nutritional status. We also analyzed several biochemical parameters and left ventricle ejection fraction. Forty (26.3%) patients were hospitalized due to HF exacerbation and 112 (73.7%) due to planned HF evaluation. The median age was 57 (48–62) years. Patients with low somatic HRQoL score had lower transferrin saturation (23.7 ± 11.1 vs. 29.7 ± 12.5%; p = 0.01), LDL (2.40 (1.80–2.92) vs. 2.99 (2.38–3.60) mmol/L; p = 0.001), triglycerides (1.18 (0.91–1.57) vs. 1.48 (1.27–2.13) mmol/L; p = 0.006) and LVEF (20 (15–25) vs. 25 (20–30)%; p = 0.003). TIBC (64.9 (58.5–68.2) vs. 57.7 (52.7–68.6); p = 0.02) was significantly higher in this group. We observed no associations between HRQoL and age or gender. The somatic domain of WHOQoL-BREF in patients with HFrEF correlated with the clinical status as well as biochemical and echocardiographic parameters. Assessment of HRQoL in HFrEF seems important in everyday practice and can identify patients requiring a special intervention

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Impact of Clinical, Biochemical, and Echocardiographic Parameters on the Quality of Life in Patients with Heart Failure with Reduced Ejection Fraction

Kałużna‐Oleksy

Sawczak

Kukfisz

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Natriuretic peptides are cardiac-derived hormones with natriuretic, diuretic, and vasodilatory effects. They are secreted into the circulation in response to increased cardiac wall stress and have robust diagnostic power for cardiac vs. non-cardiac dyspnea as well as prognostic significance in patients with HF in terms of recurrent hospitalizations and death [ 31 ]. Pro-BNP has been reported as one of the strongest predictors of death among patients with or without HF [ 13 ], especially when determined in an acute clinical setting [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Pro-BNP for Heart Failure Readmission after an Acute Coronary Syndrome

Cordero

Rey-Rañal

Moreno

et al. 2021

JCM

View full text Add to dashboard Cite

Background: N-terminal pro-brain natural peptide (NT-pro-BNP) is a well-established biomarker of tissue congestion and has prognostic value in patients with heart failure (HF). Nonetheless, there is scarce evidence on its predictive capacity for HF re-admission after an acute coronary syndrome (ACS). We performed a prospective, single-center study in all patients discharged after an ACS. HF re-admission was analyzed by competing risk regression, taking all-cause mortality as a competing event. Results are presented as sub-hazard ratios (sHR). Recurrent hospitalizations were tested by negative binomial regression, and results are presented as incidence risk ratio (IRR). Results: Of the 2133 included patients, 528 (24.8%) had HF during the ACS hospitalization, and their pro-BNP levels were higher (3220 pg/mL vs. 684.2 pg/mL; p < 0.001). In-hospital mortality was 2.9%, and pro-BNP was similarly higher in these patients. Increased pro-BNP levels were correlated to increased risk of HF or death during the hospitalization. Over follow-up (median 38 months) 243 (11.7%) patients had at least one hospital readmission for HF and 151 (7.1%) had more than one. Complete revascularization had a preventive effect on HF readmission, whereas several other variables were associated with higher risk. Pro-BNP was independently associated with HF admission (sHR: 1.47) and readmission (IRR: 1.45) at any age. Significant interactions were found for the predictive value of pro-BNP in women, diabetes, renal dysfunction, STEMI and patients without troponin elevation. Conclusions: In-hospital determination of pro-BNP is an independent predictor of HF readmission after an ACS.

show abstract

“…Diabetes contributes to higher postinfarction morbidity in individuals who have already suffered an acute MI and is associated with a higher mortality rate in these patients [ 4 ]. The development of diabetes and its associated cardiovascular complications can be linked to oxidative stress and increased apoptosis [ 5 ]. Chronic hyperglycemia and advanced glycation end products are responsible for the formation of superoxide anions and reactive oxygen species (ROS), both of which contribute to an increased risk of developing cardiovascular disease [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway

et al. 2023

View full text Add to dashboard Cite

The study was conducted to determine whether corosolic acid could protect the myocardium of diabetic rats from damage caused by isoproterenol (ISO) and, if so, how peroxisome proliferator-activated receptor gamma (PPAR-γ) activation might contribute into this protection. Diabetes in the rats was induced by streptozotocin (STZ), and it was divided into four groups: the diabetic control group, diabetic rats treated with corosolic acid, diabetic rats treated with GW9662, and diabetic rats treated with corosolic acid plus GW9662. The study was carried out for 28 days. The diabetic control and ISO control groups showed a decrease in mean arterial pressure (MAP) and diastolic arterial pressure (DAP) and an increase in systolic arterial pressure (SAP). The rat myocardium was activated by corosolic acid treatment, which elevated PPAR-γ expression. A histopathological analysis showed a significant reduction in myocardial damage by reducing myonecrosis and edema. It was found that myocardial levels of CK-MB and LDH levels were significantly increased after treatment with corosolic acid. By decreasing lipid peroxidation and increasing endogenous antioxidant levels, corosolic acid therapy showed a significant improvement over the ISO diabetic group. In conclusion, our results prove that corosolic acid can ameliorate ISO-induced acute myocardial injury in rats. Based on these results, corosolic acid seems to be a viable new target for the treatment of cardiovascular diseases and other diseases of a similar nature.

show abstract

Incidence, prognosis and predictors of heart failure after acute myocardial infarction

Cited by 5 publications

References 25 publications

The Impact of Clinical, Biochemical, and Echocardiographic Parameters on the Quality of Life in Patients with Heart Failure with Reduced Ejection Fraction

The Impact of Clinical, Biochemical, and Echocardiographic Parameters on the Quality of Life in Patients with Heart Failure with Reduced Ejection Fraction

Predictive Value of Pro-BNP for Heart Failure Readmission after an Acute Coronary Syndrome

The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway

Contact Info

Product

Resources

About