The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway

Alkholifi, Faisal K.; Devi, Sushma; Yusufoğlu, Hasan Soliman; Alam, Aftab

doi:10.3390/molecules28030929

Cited by 11 publications

(5 citation statements)

References 50 publications

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“…CA administration would seem to increase PPAR-γ activity in myocardial cells, exerting anti-oxidant effects by decreasing ROS production, normalizing CK-MB and LDH levels, and stabilizing the cardiomyocyte cell membrane. These results highlight the role of PPAR-γ pathway activation in the cardioprotective effects of CA [46] (Figure 1).…”

Section: Anti-inflammatory and Anti-oxidant Effectssupporting

confidence: 52%

Anti-Dyslipidemic and Anti-Diabetic Properties of Corosolic Acid: A Narrative Review

Cannarella,

Garofalo,

Calogero

2023

Endocrines

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Corosolic acid (CA), a natural compound derived from the Banaba tree (Lagerstroemia speciosa), has attracted attention for its potential therapeutic properties in the management of metabolic diseases. This narrative review aims to summarize the current evidence on the anti-dyslipidemic, anti-diabetic, and anti-inflammatory effects of CA and to understand the pharmacokinetics and molecular mechanisms through the analysis of preclinical and clinical studies.

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Section: Anti-inflammatory and Anti-oxidant Effectssupporting

confidence: 52%

Anti-Dyslipidemic and Anti-Diabetic Properties of Corosolic Acid: A Narrative Review

Cannarella,

Garofalo,

Calogero

2023

Endocrines

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“…Numerous synthetic medications were utilized as anti-inflammatory agents to lessen myocardial damage since inflammatory responses and signals play a significant part in cardiovascular disease (CVD). According to a recent study, excessive levels of the proinflammatory cytokines TNF-α and IL-6 cause myocardial damage, which is primarily caused by the activation of NF-kB [ 47 , 48 ]. NF-kB is typically stopped from activating the inhibitory kappa B (IkB) family.…”

Section: Discussionmentioning

confidence: 99%

Effects of Taraxerol on Oxidative and Inflammatory Mediators in Isoproterenol-Induced Cardiotoxicity in an Animal Model

et al. 2023

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Myocardial infarction (MI) continues to be an important issue in healthcare systems worldwide, leading to high rates of morbidity and mortality. Despite ongoing efforts towards the development of preventive measures and treatments, addressing the challenges posed by MI remains difficult both in developed and developing countries. However, researchers recently investigated the potential cardioprotective effects of taraxerol utilizing an isoproterenol (ISO)-induced cardiotoxicity model among Sprague Dawley rats. Specifically, subcutaneous tissue injections consisting of 5.25 mg/kg or 8.5 mg/kg ISO were administered over two consecutive days as stimuli to induce cardiac injury. To investigate the possibility of preventing damage caused by ISO-induced cardiotoxicity by taraxerol treatment, five groups were formed: a normal control group (1% Tween 80), an ISO control group, an amlodipine group administered 5 mg/kg/day, and various doses of taraxerol. The study results showed that treatment significantly reduced cardiac marker enzymes. Additionally, pretreatment with taraxerol increased myocardial activity in SOD and GPx, leading to significant reductions in serum CK-MB levels along with MDA, TNF-α, and IL-6. Further histopathological analysis supported these observations, as treated animals had less cellular infiltration compared to untreated ones. These multifaceted findings suggest that oral administration of taraxerol could potentially protect hearts from ISO-caused damage by increasing endogenous antioxidant concentrations while decreasing pro-inflammatory cytokines.

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“…The development of DM was begun by administering a single ip dose of 65 mg/kg STZ that had been dissolved in citrate buffer (100 mM, pH 4.5) according to the meth-od described in the reference source provided 25 . All animals involved in the experiment were fed a high-fat diet, except the normal control group, who received citrate buffer only.…”

Section: Methodsmentioning

confidence: 99%

Effects of kaempherol-3-rhamnoside on metabolic enzymes and AMPK in the liver tissue of STZ-induced diabetes in mice

Aodah,

Alkholifi,

Alharthy

et al. 2024

Sci Rep

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Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. It involves disturbances in carbohydrate, fat, and protein metabolism due to defects in insulin secretion, insulin action, or both. Novel therapeutic approaches are continuously being explored to enhance metabolic control and prevent complications associated with the disease. This study investigates the therapeutic potential of kaempherol-3-rhamnoside, a flavonoid, in managing diabetes by modulating the AMP-activated protein kinase (AMPK) pathway and improving metabolic enzyme activities in streptozotocin (STZ) -induced diabetic mice. Diabetic mice were treated with varying doses of kaempherol-3-rhamnoside and/or insulin over a 28-day period. Glycolytic and gluconeogenesis enzyme activities in the liver, fasting blood glucose levels, serum insulin levels, lipid profiles and oxidative stress markers were assessed. Treatment with kaempherol-3-rhamnoside significantly improved glycolytic enzyme activities, reduced fasting blood glucose, and enhanced insulin levels compared to diabetic controls. The compound also normalized lipid profiles and reduced oxidative stress in the liver, suggesting its potential in reversing diabetic dyslipidemia and oxidative damage. Furthermore, kaempherol-3-rhamnoside activated the AMPK pathway, indicating a mechanism through which it could exert its effects. Kaempherol-3-rhamnoside exhibits promising antidiabetic properties, potentially through AMPK pathway activation and metabolic enzyme modulation. These findings support its potential use as an adjunct therapy for diabetes management. Further clinical studies are warranted to validate these results in human subjects.

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The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway

Cited by 11 publications

References 50 publications

Anti-Dyslipidemic and Anti-Diabetic Properties of Corosolic Acid: A Narrative Review

Anti-Dyslipidemic and Anti-Diabetic Properties of Corosolic Acid: A Narrative Review

Effects of Taraxerol on Oxidative and Inflammatory Mediators in Isoproterenol-Induced Cardiotoxicity in an Animal Model

Effects of kaempherol-3-rhamnoside on metabolic enzymes and AMPK in the liver tissue of STZ-induced diabetes in mice

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