Incidence, prevalence and clinical course of primary biliary cirrhosis in a Spanish community

Abstract

Incidence and prevalence in our reference area are higher than in some Spanish areas, as per the results previously published; however, they are comparable with those obtained in Northern Europe and the US.

Geoepidemiology and changing mortality in primary biliary cholangitis

“…In a large cohort of asymptomatic patients in the Newcastle area, the median age at presentation was 63.1 years, which is comparable with more recent figures from Italy [15]. In more recent years, both incidence and prevalence higher than before have been reported (Table 1) [16][17][18].…”

Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: A systematic review

“…Of included articles, 19 reported incidence or prevalence rates in Europe [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34], seven in North-America [35][36][37][38][39][40][41], three in Asia [42][43][44], and two in Australia [45,46]. Studies varied in size from 10 to 770 patients in catchment areas from 100,312 to 19,230,000 inhabitants.…”

“…All eight studies depicting yearly prevalence rates for several consecutive years reported increased prevalence rates in time ( Fig. 4) [19,22,23,[25][26][27]30,38].…”

The epidemiology and natural history of primary biliary cirrhosis

“…These preliminary studies often relied on a single source for case identification and found the incidence of PBC to be between 0.6 and 13.7 new cases per million each year and prevalence to be between 23 and 128 cases per million [2][3][4][5][6][7][8][9]. Studies conducted more recently have shown markedly higher results, with an incidence of 0.7-49 cases per million a year and prevalence between 6.7 and 492 cases per million [1,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. PBC has generally been considered to be more prevalent in Europe and North America than elsewhere [1,29], but this is now being questioned [28].…”

“…PBC has generally been considered to be more prevalent in Europe and North America than elsewhere [1,29], but this is now being questioned [28]. Very few population-based studies on this subject have been conducted [19,20,24,25,27], and only three [24,25,27] have been conducted in the past decade. Few studies have covered as broad a time period as the current study, and to our knowledge no study has dealt with the epidemiology of this disease on a nationwide scale.…”