The epidemiology and natural history of primary biliary cirrhosis

Baldursdóttir, Theodóra Rún; Bergmann, Ottar M.; Jonasson, Jón G.; Lúðvíksson, Björn Rúnar; Axelsson, Tomas; Bjõrnsson, Einar

doi:10.1097/meg.0b013e328353753d

Cited by 61 publications

(46 citation statements)

References 31 publications

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“…In a large cohort of asymptomatic patients in the Newcastle area, the median age at presentation was 63.1 years, which is comparable with more recent figures from Italy [15]. In more recent years, both incidence and prevalence higher than before have been reported (Table 1) [16][17][18].…”

Section: Geoepidemiologysupporting

confidence: 72%

Geoepidemiology and changing mortality in primary biliary cholangitis

et al. 2017

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Section: Geoepidemiologysupporting

confidence: 72%

Geoepidemiology and changing mortality in primary biliary cholangitis

et al. 2017

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“…The Icelandic study used the WHO World Standard Population [42] , and that choice had a large impact on incidence estimates -even larger than what we showed for AIH in figure 1 . Before standardization, the incidence in Iceland was 2.4 per 100,000 during 1991-2000 and 3.4 during 2001-2010; after standardization, they were 2.0 and 2.5 per 100,000, respectively [42] . The explanation is that PBC is very much a disease of old age -more so than AIH -and the Icelandic population is older than the WHO World Standard Population.…”

Section: Aihmentioning

confidence: 49%

Worldwide Incidence of Autoimmune Liver Disease

Jepsen¹,

Grønbæk²,

Vilstrup³

2015

Dig Dis

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Background: The variation that occurs in the incidence patterns of autoimmune liver diseases may provide insight into the risk factors causing the diseases. We systematically reviewed studies on the incidence of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and immunoglobulin G4-associated cholangitis (IAC) in general populations. Key Messages: We found relevant studies through Medline and Scopus, and we examined whether they were population-based; the way they found cases for inclusion and which diagnostic criteria they used; and whether they used standardization to facilitate comparison with other studies. The 55 identified studies varied greatly in their case-finding methods, and only 14 (25%) of them used a standard population. Reported incidence rates of AIH were around 1 per 100,000 population per year, possibly higher in Scandinavia than in other countries, and a Danish study of the 1994-2012 period found an increasing incidence. A majority of PBC studies found incidence rates of 1-2 per 100,000 population per year and an increasing time trend, but incidence was lower in the Netherlands and New Zealand and higher in North East England. Most studies of PSC found incidence rates around 1 per 100,000 population per year, but there were no incident cases among 100,000 Alaska natives during the period 1984-2000. The incidence of IAC remains unknown. Conclusions: The incidence of the autoimmune liver diseases is around 1-2 per 100,000 population per year for each disease. The variation in incidence over time and place suggests that there are differences in the prevalence of risk factors for the diseases, but the studies used different methods and so it is difficult to draw firm conclusions. We recommend that groups of investigators conduct multisite studies with identical case-finding methods, and that they use a standard population to account for differences in demographics.

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“…21 Algengasti undirliggjandi sjúkdómur skorpulifrar hjá lifrarþegum á Norðurlöndum undanfarin ár hefur hins vegar verið frumkomin trefjunargallgangabólga 11,12 en athyglisvert er að í þessari rannsókn var frumkomin trefjunargallgangabólga undirliggjandi orsök skorpulifrar hjá einungis þremur sjúklingum (8%). Ekki hafa verið birtar niðurstöður rannsókna á algengi frumkominnar trefjunargallgangabólgu hér á landi.…”

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“…8,21 Ástaeða þess að fáir sjúklingar með skorpulifur af völdum áfengis fara í lifrarígraeðslu er meðal annars sú að slíkir sjúklingar hafa yfirleitt þurft að uppfylla skilyrði, svo sem að hafa ekki neytt áfengis í að minnsta kosti hálft ár auk þess sem oftast er gerð krafa um að sjúklingur hafi gengist undir áfengismeðferð.…”

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