Incidence, predictors and outcomes of infective endocarditis in a contemporary adult congenital heart disease population

Moore, Benjamin M.; Cao, Jacob; Kotchetkova, Irina; Celermajer, David S.

doi:10.1016/j.ijcard.2017.08.035

“…Previous reports from developed countries also presented that the proportion of RHD had dropped obviously, and DVD, PVE and implantable electronic devices related IE had gradually increased and replaced RHD as the leading heart disease [1,4,8] .This difference may contributed to the large number of patients with CHD and the relative low proportion of patients with prior cardiac surgery. According to the published reports, the risk of developing into IE increased in patients with CHD [14][15][16]. Darren et al [16] found that the IE risk exceeded 100 times in patients with ACHD compared to that of the general population and 2.5 times that of children with CHD [16,17].The proportion of patients with CHD in our study was as high as 25.8%.…”

Section: Discussionsupporting

confidence: 47%

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

Wu¹,

Chen

²

,

Xiao

³

et al. 2020

Preprint

0

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Background: To explore the trends in epidemiology and risk factors related to the prognosis of infective endocarditis in a teaching hospital over the past ten years. Methods: A retrospective cohort study was performed. A total of 407 consecutive patients were included. The clinical characteristics and risk factors related to the prognosis of infective endocarditis during this period were analyzed. Results: A total of 407 patients with infective endocarditis were included, the average age was 48 ±16 years old with an increasing trend and in-hospital mortality rate was 10.6% and one-year mortality rate was 12.2%. Among patients with underlying heart disease, congenital heart disease was the most common(25.8%), followed by rheumatic heart disease which showed a decreased trend during this period (P<0.001). There were 222(54.5%) positive blood cultures and streptococci (44.1%) was the main pathogens with an increasing trend. There were 403 patients (99%) with surgical indications, but only 234 patients (57.5%) received surgical treatment. Hemodialysis (P = 0.041, OR = 4.697, 95% CI 1.068-20.665), pulmonary hypertension (P = 0.001, OR = 5.308, 95% CI 2.034-13.852), Pitt score ≥ 4 (P <0.001, OR = 28.5, 95% CI 5.5-148.1) and vegetation length＞30mm (P = 0.011, OR = 13.754, 95% CI 1.832-103.250) were independent risk factors for in-hospital mortality. Conclusions: There was no significant change in the overall incidence of IE, the clinical features of IE have changed slightly during the past ten years. Streptococci IE was still the predominant. IE patients with hemodialysis, pulmonary hypertension, Pitt score ≥ 4 and vegetation length＞30mm had an worse in-hospital outcome.

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“…Previous reports from developed countries also presented that the proportion of RHD had dropped obviously, and DVD, PVE and implantable electronic devices related IE had gradually increased and replaced RHD as the leading heart disease [1, 4,8] .This difference may contributed to the large number of patients with CHD and the relative low proportion of patients with prior cardiac surgery. According to the published reports, the risk of developing into IE increased in patients with CHD [14][15][16]. Darren et al [16] found that the IE risk exceeded 100 times in patients with ACHD compared to that of the general population and 2.5 times that of children with CHD [16,17].The proportion of patients with CHD in our study was as high as 25.8%.…”

Section: Discussionsupporting

confidence: 47%

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

Wu

¹

,

Chen

²

,

Xiao

³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: To explore the trends in epidemiology and risk factors related to the prognosis of infective endocarditis in a teaching hospital over the past ten years. Methods: A retrospective cohort study was performed. A total of 407 consecutive patients were included. The clinical characteristics and risk factors related to the prognosis of infective endocarditis during this period were analyzed. Results: A total of 407 patients with infective endocarditis were included, the average age was 48 ±16 years old with an increasing trend and in-hospital mortality rate was 10.6% and one-year mortality rate was 12.2%. Among patients with underlying heart disease, congenital heart disease was the most common(25.8%), followed by rheumatic heart disease which showed a decreased trend during this period (P<0.001). There were 222(54.5%) positive blood cultures and streptococci (44.1%) was the main pathogens with an increasing trend. There were 403 patients (99%) with surgical indications, but only 234 patients (57.5%) received surgical treatment. Hemodialysis (P = 0.041, OR = 4.697, 95% CI 1.068-20.665), pulmonary hypertension (P = 0.001, OR = 5.308, 95% CI 2.034-13.852), Pitt score ≥ 4 (P <0.001, OR = 28.5, 95% CI 5.5-148.1) and vegetation length＞30mm (P = 0.011, OR = 13.754, 95% CI 1.832-103.250) were independent risk factors for in-hospital mortality. Conclusions: There was no significant change in the overall incidence of IE, the clinical features of IE have changed slightly during the past ten years. Streptococci IE was still the predominant. IE patients with hemodialysis, pulmonary hypertension, Pitt score ≥ 4 and vegetation length＞30mm had an worse in-hospital outcome.

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“…IE was an important complication for patients with CHD [21,22]. According to the published reports, the risk of developing into IE increased in patients with CHD [21,23,24]. Darren et al [24] found that the IE risk exceeded 100 times in patients with ACHD compared to that of the general population and 2.5 times that of children with CHD [24,25].The proportion of patients with CHD in our study was as high as 25.8%.…”

Section: Discussionsupporting

confidence: 46%

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

Wu¹,

Chen

²

,

Xiao

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background: To explore the trends in epidemiology and the risk factors related to the prognosis of infective endocarditis in a tertiary hospital over the past ten years. Methods: A retrospective cohort study was performed. A total of 407 consecutive patients who were admitted with infective endocarditis were included. The clinical characteristics and the risk factors related to the prognosis of infective endocarditis during this period were analyzed. Results: A total of 407 patients with infective endocarditis were included, the average age was 48 ±16 years old with an increasing trend and in-hospital mortality rate was 10.6% and one-year mortality rate was 11.3%. Among patients with underlying heart disease, congenital heart disease was the most common(25.8%), followed by rheumatic heart disease(17.0%) which showed a decreased trend during this period (P<0.001). There were 222(54.5%) patients with positive blood cultures results and Streptococci (24.6%) was the main pathogens with an increasing trend. There were 403 patients (99%) with surgical indications, but only 235 patients (57.7%) received surgical treatment. Hemodialysis (P = 0.041, OR = 4.697, 95% CI 1.068-20.665), pulmonary hypertension (P = 0.001, OR = 5.308, 95% CI 2.034-13.852), Pitt score ≥ 4 (P <0.001, OR = 28.594, 95% CI 5.561-148.173) and vegetation length＞30mm (P = 0.011, OR = 13.754, 95% CI 1.832-103.250) were independent risk factors for in-hospital mortality. Conclusions: There were no significant change in the overall incidence of infective endocarditis, but the clinical features of infective endocarditis had slightly changed during the past ten years. Streptococci infective endocarditis was still the predominant. Patients with hemodialysis, pulmonary hypertension, Pitt score ≥ 4 and vegetation length＞30mm had an worse in-hospital outcome. Keywords: Infective endocarditis, epidemiology, risk factors, mortality.

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Incidence, predictors and outcomes of infective endocarditis in a contemporary adult congenital heart disease population

Cited by 50 publications

References 29 publications

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

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