Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

Abstract

Background: To explore the trends in epidemiology and risk factors related to the prognosis of infective endocarditis in a teaching hospital over the past ten years. Methods: A retrospective cohort study was performed. A total of 407 consecutive patients were included. The clinical characteristics and risk factors related to the prognosis of infective endocarditis during this period were analyzed. Results: A total of 407 patients with infective endocarditis were included, the average age was 48 ±16 years old with an increasing trend and in-hospital mortality rate was 10.6% and one-year mortality rate was 12.2%. Among patients with underlying heart disease, congenital heart disease was the most common(25.8%), followed by rheumatic heart disease which showed a decreased trend during this period (P<0.001). There were 222(54.5%) positive blood cultures and streptococci (44.1%) was the main pathogens with an increasing trend. There were 403 patients (99%) with surgical indications, but only 234 patients (57.5%) received surgical treatment. Hemodialysis (P = 0.041, OR = 4.697, 95% CI 1.068-20.665), pulmonary hypertension (P = 0.001, OR = 5.308, 95% CI 2.034-13.852), Pitt score ≥ 4 (P <0.001, OR = 28.5, 95% CI 5.5-148.1) and vegetation length＞30mm (P = 0.011, OR = 13.754, 95% CI 1.832-103.250) were independent risk factors for in-hospital mortality. Conclusions: There was no significant change in the overall incidence of IE, the clinical features of IE have changed slightly during the past ten years. Streptococci IE was still the predominant. IE patients with hemodialysis, pulmonary hypertension, Pitt score ≥ 4 and vegetation length＞30mm had an worse in-hospital outcome.

Catastrophic Candida prosthetic valve endocarditis and COVID-19 comorbidity: A rare case

“…Endocarditis is a severe infectious disease with a high mortality rate [2][3][4][5]. Its in-hospital mortality rates are 12-17%, 23%-26%, 10%, and 8% for inherent valve, prosthetic valve, cardiac implantable electronic device, and right-sided endocarditis, respectively [6]. Fungal endocarditis in patients with prostatic valves can be a severe threat with high mortality and morbidity [7].…”

Epidemiological Profile of Patients with Infective Endocarditis at three Tertiary Centers in Brazil from 2003 to 2017

“…to be the most prevalent pathogen, which agrees with the literature. [1][2][3][4]34 However, we did not observe the reported epidemiological transition toward more cases due to Staphylococcus spp. and fewer cases due to Streptococcus spp.…”

Acute myocardial infarction as the first sign of infective endocarditis: a case report

“…2 In developing countries, the most important risk factor for IE is rheumatic heart disease, as described in this case. 3,4 A serious complication of IE is an embolic event caused by migration of cardiac vegetation. Dislodged vegetation can cause embolism in systemic blood vessels, leading to ischemic events.…”