Incidence of Type 2 Diabetes in Kuwaiti Children and Adolescents: Results From the Childhood-Onset Diabetes Electronic Registry (CODeR)

Alkandari, Hessa; Al‐Abdulrazzaq, Dalia; Davidsson, Lena; Al-Tararwa, Abeer; Mandani, Fawziya; Al-Shawaf, Faisal; Al-Hussaini, Fatma; Qabazard, M.; Haddad, Dania; Al-Mahdi, Maria; Al-Jasser, Fahad; Alanezi, Ayed; Al-Sanea, Hala; Al-Basari, Iman; Al-Adsani, Afaf; Shaltout, Azza; Abdul-Rasoul, Majedah

doi:10.3389/fendo.2019.00836

Cited by 13 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CODeR was established in 2011 and is maintained by Dasman Diabetes Institute (DDI) in collaboration with the Ministry of Health (MOH). 11 , 12 Data on newly diagnosed T1D among children aged 6 months to 12 years during the COVID‐19 pandemic period (12 months, starting from the first confirmed case of COVID‐19 in Kuwait on 24 February 2020, until 23 February 2021) were compared with those diagnosed during the same period in the previous 12 months (from 24 February 2019 till 23 February 2020). Children younger than 6 months were excluded due to the diagnosis of neonatal diabetes in this age group.…”

Section: Methodsmentioning

confidence: 99%

“…CODeR is a prospective population‐based diabetes registry and is a country‐wide surveillance system in Kuwait, with validated high ascertainment. CODeR was established in 2011 and is maintained by Dasman Diabetes Institute (DDI) in collaboration with the Ministry of Health (MOH) 11,12 . Data on newly diagnosed T1D among children aged 6 months to 12 years during the COVID‐19 pandemic period (12 months, starting from the first confirmed case of COVID‐19 in Kuwait on 24 February 2020, until 23 February 2021) were compared with those diagnosed during the same period in the previous 12 months (from 24 February 2019 till 23 February 2020).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Higher rates of diabetic ketoacidosis and admission to the paediatric intensive care unit among newly diagnosed children with type 1 diabetes in Kuwait during the COVID‐19 pandemic

Al‐Abdulrazzaq

Alkandari

Alhusaini

et al. 2021

Diabetes Metabolism Res

View full text Add to dashboard Cite

Introduction The COVID‐19 pandemic might have a multifaceted effect on children with type 1 diabetes (T1D), either directly through infection itself or indirectly due to measures implemented by health authorities to control the pandemic. Objective To compare data on children newly diagnosed with T1D in Kuwait during the COVID‐19 pandemic to the pre‐pandemic period. Research Design and Methods We analysed data on children aged 12 years or less registered in the Childhood‐Onset Diabetes electronic Registry (CODeR) in Kuwait. Data were incidence rate (IR), diabetic ketoacidosis (DKA), and its severity and admission to the paediatric intensive care unit (PICU). Results The IR of T1D was 40.2 per 100,000 (95% CI; 36.0–44.8) during the COVID‐19 pandemic period and was not statistically different from pre‐pandemic. A higher proportion of incident T1D cases presented with DKA and were admitted to the PICU during the pandemic (52.2% vs. 37.8%: p ˂ 0.001, 19.8% vs. 10.9%; p = 0.002, respectively). The COVID‐19 pandemic was positively associated with presentation of DKA and admission to PICU (AOR = 1.73; 95% CI, 1.13–2.65; p = 0.012, AOR = 2.04; 95% CI, 1.13–3.67; p = 0.018, respectively). Children of families with a positive history for diabetes were less likely to present with DKA and get admitted to the PICU during the COVID‐19 pandemic (AOR = 0.38; 95% CI, 0.20–0.74; p = 0.004, AOR = 0.22; 95% CI, 0.08–0.61; p = 0.004, respectively). Conclusion High rates of DKA at presentation and admission to PICU in incident T1D cases during the COVID‐19 pandemic warrant further studies and effective mitigation efforts through increasing awareness, early detection, and timely intervention.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Higher rates of diabetic ketoacidosis and admission to the paediatric intensive care unit among newly diagnosed children with type 1 diabetes in Kuwait during the COVID‐19 pandemic

Al‐Abdulrazzaq

Alkandari

Alhusaini

et al. 2021

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

“…We could not find recent data about the overall prevalence of T2D in children and adolescents in the MENA region; however, data from specific countries reflect an increasing incidence and prevalence of T2D in this age group. In Kuwait, for instance, the incidence rate of T2D between 2011 and 2013 among children and adolescents, aged ≤ 14 years, was 2.56 per 100000 per year[ 116 ]. In Qatar, there were no registered cases of T2D among children and adolescents before 2008.…”

Section: Diabetes In Children and Adolescentsmentioning

confidence: 99%

Epidemiology of type 2 diabetes in the Middle East and North Africa: Challenges and call for action

El‐Kebbi¹,

Bidikian²,

Hneiny³

et al. 2021

WJD

View full text Add to dashboard Cite

Type 2 diabetes continues to be a serious and highly prevalent public health problem worldwide. In 2019, the highest prevalence of diabetes in the world at 12.2%, with its associated morbidity and mortality, was found in the Middle East and North Africa region. In addition to a genetic predisposition in its population, evidence suggests that obesity, physical inactivity, urbanization, and poor nutritional habits have contributed to the high prevalence of diabetes and prediabetes in the region. These risk factors have also led to an earlier onset of type 2 diabetes among children and adolescents, negatively affecting the productive years of the youth and their quality of life. Furthermore, efforts to control the rising prevalence of diabetes and its complications have been challenged and complicated by the political instability and armed conflict in some countries of the region and the recent coronavirus disease 2019. Broad strategies, coupled with targeted interventions at the regional, national, and community levels are needed to address and curb the spread of this public health crisis.

show abstract

“…Overall, the incidence of paediatric-onset type 1 diabetes is still greater than paediatric type 2 diabetes. However, particularly among adolescents, the proportion of newly diagnosed youth-onset diabetes represented by type 2 diabetes is increasing, with estimated incidence rates ranging from 0.72/100,000 in the UK [1] to 2.56/100,000 in Kuwait [2] and 3.45/100,000 in Canada [3]. Moreover, in many countries, including Qatar [4], the USA [5], the UK [1], Canada [3] and China [6], the incidence is currently rising several percentage points per year.…”

Section: Background Epidemiologymentioning

confidence: 99%

Youth-onset type 2 diabetes: translating epidemiology into clinical trials

Pyle

Kelsey

2021

Diabetologia

View full text Add to dashboard Cite

Globally, the proportion of new diagnoses of youth-onset diabetes represented by type 2 diabetes is increasing, and youth with type 2 diabetes commonly have complications and comorbidities, as well as a higher rate of mortality. In this review, we summarise what is known about the natural progression of youth-onset type 2 diabetes from published clinical trials and large-scale prospective epidemiological studies. It is important to note that the robust pathophysiological and treatment data specifically related to individuals with a diabetes onset at ≤20 years of age largely hails from the USA. Youth-onset type 2 diabetes is characterised by pathophysiological heterogeneity and inadequate glycaemic control, highlighting the need for new treatment approaches and innovative study designs in populations of varied genetic and cultural backgrounds.

show abstract

Incidence of Type 2 Diabetes in Kuwaiti Children and Adolescents: Results From the Childhood-Onset Diabetes Electronic Registry (CODeR)

Cited by 13 publications

References 30 publications

Higher rates of diabetic ketoacidosis and admission to the paediatric intensive care unit among newly diagnosed children with type 1 diabetes in Kuwait during the COVID‐19 pandemic

Higher rates of diabetic ketoacidosis and admission to the paediatric intensive care unit among newly diagnosed children with type 1 diabetes in Kuwait during the COVID‐19 pandemic

Epidemiology of type 2 diabetes in the Middle East and North Africa: Challenges and call for action

Youth-onset type 2 diabetes: translating epidemiology into clinical trials

Contact Info

Product

Resources

About