Incidence of sleep disturbances in patients with familial Mediterranean fever and the relation of sleep quality with disease activity

Küçükşahin, Orhan; Omma, Ahmet; Özdemirel, Ali Erhan; Tecer, Duygu; Ulutas, Sümeyye; Maraş, Yüksel; Balkarlı, Ayşe; Erten, Şükran

doi:10.1111/1756-185x.13104

Cited by 17 publications

(31 citation statements)

References 36 publications

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“…1,2,9 In previous studies, a higher frequency of anxiety and depression in FMF patients has been reported. 3,5,8 In accordance with these results, we also detected a higher frequency of anxiety and depression using the subscales of HADS. In correlation analysis, we also showed a positive correlation between the FMF-QoL Scale score and HADS scores.…”

Section: Discussionsupporting

confidence: 89%

“…1,2 It is a lifelong disease with harmful effects on all aspects of quality of life (QoL) due to the presence of recurrent attacks and side effects of medical treatment. 3 The concept of health-related QoL is known as the measurement of physical symptoms, functional status, and effects of the disease on psychological and social functioning. 2 As in other chronic diseases, the problems in relation to QoL for FMF patients have become an important health topic particularly during the last decades.…”

Section: Familialmentioning

confidence: 99%

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Familial Mediterranean fever: Health-related quality of life and associated variables in a national cohort

et al. 2020

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Objectives This study aims to evaluate the effectivity of Familial Mediterranean Fever Quality of Life (FMF-QoL) Scale for the measurement of QoL in patients with FMF and to perform correlations between related clinical variables in Turkish patients. Patients and methods This multicenter prospective study performed between December 2017 and November 2018 included 974 FMF patients (334 males, 640 females; median age: 35; range, 26 to 45 years). Sociodemographic characteristics and clinical features were recorded. All participants were asked to complete the FMF-QoL Scale, Short Form-36 (SF-36), Hospital Anxiety and Depression Scale (HADS), Health Assessment Questionnaire (HAQ), and Functional Assessment of Chronic Illness Therapy (FACIT) Scale. Results The median FMF-QoL Scale score was 26. Higher FMF-QoL Scale scores were shown to be related to female sex, illiteracy or primary education, monthly low-income (US$<300), smoking, late-onset FMF (>20 years), a higher number of attacks per month (>1/month), and severe disease. FMF-QoL Scale scores were correlated negatively with subscales of SF-36, and positively with HADS-anxiety and HADS-depression scores, HAQ and FACIT. Conclusion Female sex, smoking, lower educational status, more severe disease, fatigue, and functional impairment were associated with poor QoL. FMF-QoL Scale was noted as a valid and simple patient-reported outcome instrument and correlated with the SF-36 scale.

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Section: Discussionsupporting

confidence: 89%

Section: Familialmentioning

confidence: 99%

Familial Mediterranean fever: Health-related quality of life and associated variables in a national cohort

et al. 2020

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“…In a study on adult patients with FMF, it was shown that FMF patients have a worse sleep pattern compared to healthy individuals. 25 Another study with children with FMF indicated higher total sleeping scores, sleep onset delay, sleep anxiety, nightwakings and sleep-disordered breathing scores in patients with FMF compared to healthy peers. 13 Similarly, in our study, total sleep score, nightwakings and sleep-disordered breathing scores were higher in patients, while sleep onset delay and sleep anxiety scores were similar; but unlike previous studies, bedtime resistance and parasomnia scores were significantly higher in patients.…”

Section: Discussionmentioning

confidence: 96%

“…In a study on adult patients with FMF, it was shown that FMF patients have a worse sleep pattern compared to healthy individuals 25 . Another study with children with FMF indicated higher total sleeping scores, sleep onset delay, sleep anxiety, nightwakings and sleep‐disordered breathing scores in patients with FMF compared to healthy peers 13 .…”

Section: Discussionmentioning

confidence: 99%

“…In another study, the number of attacks in the last 3 months and level of ESR during attacks were shown to be related with poor sleep quality. 25 There is another study reporting that patients with high acute phase reactants had higher anxiety scores than those without. 26 In future studies, measurement of acute phase reactants, proinflammatory cytokines (such as IL-6, TNF-alpha etc) during and between the attacks would be helpful to determine the impact of inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Increased frequency of sleep problems in children and adolescents with familial Mediterranean fever: The role of anxiety and depression

et al. 2020

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Aim: Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory disease. The main goal of our study is to compare sleep habits, depression and anxiety of patients with FMF to healthy children and to determine the influence of disease-related factors on sleep habits and psychiatric symptoms. Method: In total, 323 child and adolescent patients with FMF and 260 healthy peers as a control group were included in this study. Questionnaires were used to evaluate sleep habits, psychological status of children and adolescents with and without FMF. Results: While there was not a significant difference in terms of age, gender, depression and anxiety scores (P > 0.05); patients with FMF had significantly higher total sleeping score (45.69 ± 7.70 vs 43.31 ± 7.77; P = 0.001). Depression and anxiety scores of patients with FMF who have been experiencing sleep problems were found to be dramatically higher compared to those FMF patients without sleep problems (7.70 ± 5.56 vs 4.59 ± 3.97; P = 0.001; 35.46 ± 18.57 vs 25.22 ± 14.12; P = 0.001; respectively). Patients with FMF who had a disease attack last month had remarkably higher depression, anxiety and sleeping scores compared to those who did not. When FMF patients were compared in terms of exertional leg pain, increased acute phase reactant levels, comorbidity and mutation types, there was not a significant difference for depression, anxiety and sleeping scores. Conclusion: Children and adolescents with FMF experience more sleeping problems compared to healthy children and in presence of sleeping disorders, psychiatric symptoms are seen more frequently. Therefore, evaluation of psychopathology is important if youth with FMF have sleep problems.

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Decreased serum vitamin B12 and vitamin D levels affect sleep quality in children with familial Mediterranean fever

et al. 2017

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Familial Mediterranean fever is an autoinflammatory disorder characterized by recurrent fever and serositis. We aimed to describe serum vitamin B and vitamin D levels and their correlation with self-reported sleep quality of pediatric FMF patients. Sixty-three children with FMF were enrolled to the study. Information on sleep quality was obtained using self-administration of Pittsburg Sleep Quality Index (PSQI). The patients were divided into subgroups depending on vitamin D serum concentrations: ≥ 20 and < 20 ng/ml. We also grouped patients according to their serum B concentration: ≥ 200, < 200 pg/ml. B levels were not correlated with PSQI scores, whereas significant correlation was found between vitamin D and total PSQI scores and daytime sleepiness. Total PSQI score, sleep disorders and daytime sleepiness sub-scores were statistically high in patients with serum D vitamin levels below 20 ng/ml. Sleep efficiency was found lower in patients with serum B levels below 200 pg/ml. B may have a positive role on effective sleep. More importantly, we suggest that vitamin D is protective against sleep disorders and poor sleep, it may also improve daytime activities.

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Incidence of sleep disturbances in patients with familial Mediterranean fever and the relation of sleep quality with disease activity

Abstract: Poor sleep quality is common in adult FMF patients. Anxiety, depression and fatigue are more frequent in FMF patients than healthy individuals. Poor sleep quality is associated with inflammatory marker levels during attacks, fatigue and attack numbers in the last 3 months.

Cited by 17 publications

References 36 publications

Familial Mediterranean fever: Health-related quality of life and associated variables in a national cohort

Familial Mediterranean fever: Health-related quality of life and associated variables in a national cohort

Increased frequency of sleep problems in children and adolescents with familial Mediterranean fever: The role of anxiety and depression

Decreased serum vitamin B12 and vitamin D levels affect sleep quality in children with familial Mediterranean fever

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