Familial Mediterranean fever: Health-related quality of life and associated variables in a national cohort

Abstract

Objectives This study aims to evaluate the effectivity of Familial Mediterranean Fever Quality of Life (FMF-QoL) Scale for the measurement of QoL in patients with FMF and to perform correlations between related clinical variables in Turkish patients. Patients and methods This multicenter prospective study performed between December 2017 and November 2018 included 974 FMF patients (334 males, 640 females; median age: 35; range, 26 to 45 years). Sociodemographic characteristics and clinical features were recorded. All participants were asked to complete the FMF-QoL Scale, Short Form-36 (SF-36), Hospital Anxiety and Depression Scale (HADS), Health Assessment Questionnaire (HAQ), and Functional Assessment of Chronic Illness Therapy (FACIT) Scale. Results The median FMF-QoL Scale score was 26. Higher FMF-QoL Scale scores were shown to be related to female sex, illiteracy or primary education, monthly low-income (US$<300), smoking, late-onset FMF (>20 years), a higher number of attacks per month (>1/month), and severe disease. FMF-QoL Scale scores were correlated negatively with subscales of SF-36, and positively with HADS-anxiety and HADS-depression scores, HAQ and FACIT. Conclusion Female sex, smoking, lower educational status, more severe disease, fatigue, and functional impairment were associated with poor QoL. FMF-QoL Scale was noted as a valid and simple patient-reported outcome instrument and correlated with the SF-36 scale.

Coexistence of Rheumatoid Arthritis and Familial Mediterrean Fever: A Case Report and Review of the Literature

“…Bodur et al reported the first study which assessed QoL in FMF patients using the FMF-QoL Scale(18). As reported in this study our patient was female sex, which was associated with QoL in FMF.…”

Colchicine resistance: Associated factors and its effect on health‐related quality of life in patients with familial Mediterranean fever

“…On the other hand, the FMF‐QoL scale and the subscales of SF‐36, except for role emotional and vitality subscales, were significantly different between colchicine‐resistant and non‐resistant groups, and FMF patients with colchicine resistance had poorer QoL in the current study. Bodur et al 31 found a significant association between the frequency of more than 1 attack per month and FMF‐QoL. Another study reported the association of FMF‐QoL scale with the annual number of attacks and disease severity 20 .…”

The frequency of fibromyalgia in familial Mediterranean fever and its impact on the quality of life

“…For the assessments of QoL and functioning in cases with FMF, FMF‐QoL, Short form 36 (SF‐36), and Health Assessment Questionnaire‐Disability Index (HAQ‐DI) were used. The FMF‐QoL Scale includes 20 questions to evaluate the health status in relation to physical, social, recreational, psychological, and sleep impact factors 13 . Total score may change from 0 to 80 where a higher score represents poor QoL 14 …”

“…The FMF-QoL Scale includes 20 questions to evaluate the health status in relation to physical, social, recreational, psychological, and sleep impact factors. 13 Total score may change from 0 to 80 where a higher score represents poor QoL. 14 The SF-36 has 36 items with eight subscales.…”