1994
DOI: 10.1016/s0936-6555(05)80187-6
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Incidence of second brain tumours after pituitary irradiation in Edinburgh 1962–1990

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Cited by 75 publications
(39 citation statements)
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“…Meningioma was diagnosed many years after RxT only in two patients. The occurrence of a second neoplasm in the field of irradiation has been already described as a rare event (41)(42)(43). In our opinion the causal relationship between the two events needs to be demonstrated, with the use of a proper control group (non-irradiated acromegalics), because we have observed the occurrence of meningioma even in some acromegalic patients not irradiated and an increase of tumor prevalence has been already shown in this population (3).…”
Section: Discussionmentioning
confidence: 63%
“…Meningioma was diagnosed many years after RxT only in two patients. The occurrence of a second neoplasm in the field of irradiation has been already described as a rare event (41)(42)(43). In our opinion the causal relationship between the two events needs to be demonstrated, with the use of a proper control group (non-irradiated acromegalics), because we have observed the occurrence of meningioma even in some acromegalic patients not irradiated and an increase of tumor prevalence has been already shown in this population (3).…”
Section: Discussionmentioning
confidence: 63%
“…First, they usually have a long latency period after radiation: although a wide range in the latency period has been reported following high-dose radiation (12 Brain tumour stem cell-mediated radiation-induced meningioma months to 63 years), the mean latency period is 18.7 ± 10.2 years. 2,3,6,7,25,26 Secondly, most patients were juveniles: of the patients whose ages were reported, all were in the paediatric age group (the majority < 5 years old at the time of cranial radiation following brain tumour diagnosis) except for one young adult patient. This may be because more chromosomal injury is caused by radiation in the developing nervous tissue of young children 7 and the meninges of children are extremely sensitive and, thus, more vulnerable to radiation.…”
Section: Discussionmentioning
confidence: 99%
“…Prospective assessment of cognitive functions was not performed in the great majority of the studies. Although the incidence of second brain tumors after pituitary irradiation is low, literature studies [29][30][31][32] have reported a cumulative risk of developing a second brain tumor in patients harboring pituitary adenomas, when treated with radiotherapy. In fact, in a recent study, Minniti et al reported that an increased risk of second brain tumors goes beyond 20-30 years after treatment.…”
Section: Discussionmentioning
confidence: 99%