Incidence of Post-Infectious Irritable Bowel Syndrome and Functional Intestinal Disorders Following a Water-Borne Viral Gastroenteritis Outbreak

Zanini, Bárbara; Ricci, Chiara; Bandera, Floriana; Caselani, Francesca; Magni, Alberto; Laronga, Anna Maria; Lanzini, Alberto

doi:10.1038/ajg.2012.102

Cited by 148 publications

(98 citation statements)

References 27 publications

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“…Zanini et al [16] reported that 19% of 348 patients with irritable bowel syndrome had weight loss and that the mean weight loss was 3 kg. In a study investigating laboratory parameters and the nutritional status of 180 patients who were diagnosed with FD based on the Rome II criteria, 30 (16.67%) patients had weight loss between 5 and 10% of their initial body weight, and 8 (4.44%) had weight loss of >10% of their initial body weight [17].…”

Section: Discussionmentioning

confidence: 99%

The Clinical-Psychological Features of Functional Dyspepsia Patients with Weight Loss: A Multi-Center Study from China

Liu

Jia²,

Lei³

et al. 2015

Digestion

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Aims: To investigate the clinical features, appetite, quality of life (QOL), and their associated psychological factors of functional dyspepsia (FD) patients with weight loss. Methods: For a multicenter study, FD patients were recruited and divided into two groups according to the degree of weight changes during the previous 12 months or less with the onset of dyspepsia symptoms: Group A (≥5%) and Group B (<5%). Patients were evaluated based on the Nepean dyspepsia index (NDI), appetite questionnaire, Hamilton Rating Scale of Anxiety/Depression (HAMA/HAMD). Results: The body mass index in Group A was lower than in Group B, while, the frequency of physician visits in Group A was higher than in Group B. There were no differences in the total scores of NDI-symptom checklist or the items of intensity and bothersomeness between them (p > 0.05), but the frequency item for Group A was significantly higher than Group B (p = 0.035). The incidence of anxiety or depression, the proportion of poor or very poor appetite for Group A was higher than those for Group B (p < 0.05). Subscale scores of the NDI-QOL for Group A were significantly lower than those for Group B (p < 0.05). Conclusions: FD patients with weight loss have lower BMI, more frequent physician visits, higher psychological disorders, poorer appetite and QoL.

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Section: Discussionmentioning

confidence: 99%

The Clinical-Psychological Features of Functional Dyspepsia Patients with Weight Loss: A Multi-Center Study from China

Liu

Jia²,

Lei³

et al. 2015

Digestion

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“…Gemulla and Pessler reported 2 cases of possible postinfectious arthritis related to norovirus infection (72). Thirteen percent of patients who had been affected during a waterborne norovirus outbreak and who responded to a questionnaire reported symptoms consistent with irritable bowel syndrome 12 months after their infection (73).…”

Section: Figmentioning

confidence: 99%

Norovirus

2015

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SUMMARY Norovirus, an RNA virus of the family Caliciviridae , is a human enteric pathogen that causes substantial morbidity across both health care and community settings. Several factors enhance the transmissibility of norovirus, including the small inoculum required to produce infection (<100 viral particles), prolonged viral shedding, and its ability to survive in the environment. In this review, we describe the basic virology and immunology of noroviruses, the clinical disease resulting from infection and its diagnosis and management, as well as host and pathogen factors that complicate vaccine development. Additionally, we discuss overall epidemiology, infection control strategies, and global reporting efforts aimed at controlling this worldwide cause of acute gastroenteritis. Prompt implementation of infection control measures remains the mainstay of norovirus outbreak management.

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“…Disease severity is usually moderate, but morbidity and mortality rates due to NoV infection are increasingly becoming evident, with particularly high tolls taken on children and immunocompromised and aged populations (2)(3)(4)(5)(6)(7)(8)(9), resulting in an estimated 200,000 deaths per year (10). In addition, postinfectious irritable bowel syndrome develops in a substantial portion of patients (11). These groups of people, in addition to military personnel, childcare and health care providers, and food handlers, would benefit from a NoV vaccine.…”

mentioning

confidence: 99%

Emergence of a Norovirus GII.4 Strain Correlates with Changes in Evolving Blockade Epitopes

Lindesmith

Costantini

Swanstrom

et al. 2013

J Virol

145

141

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Incidence of Post-Infectious Irritable Bowel Syndrome and Functional Intestinal Disorders Following a Water-Borne Viral Gastroenteritis Outbreak

Abstract: Our study provides evidence that Norovirus GE leads to the development of PI-IBS in a substantial proportion of patients (13%), similar to that reported after bacterial GE.

Cited by 148 publications

References 27 publications

The Clinical-Psychological Features of Functional Dyspepsia Patients with Weight Loss: A Multi-Center Study from China

The Clinical-Psychological Features of Functional Dyspepsia Patients with Weight Loss: A Multi-Center Study from China

Norovirus

Emergence of a Norovirus GII.4 Strain Correlates with Changes in Evolving Blockade Epitopes

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