Incidence of permanent hypocalcaemia after total thyroidectomy with or without central neck dissection for thyroid carcinoma: a nationwide claim study

Seo, Gi Hyeon; Chai, Young Jun; Choi, Hyung Jin; Lee, Kyu Eun

doi:10.1111/cen.13082

Cited by 26 publications

(23 citation statements)

References 34 publications

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“…5 Most of the previous studies set the size threshold between 5 and 10 mm, but in cases when the tumor was less than this threshold, the incidence of CLNM was still high, ranging from 26% to 55%. 28,29 The results of this study showed that tumor size larger than 8 mm was independently predictive of CLNM in cN0 PTC without capsule invasion. Despite this, CLNM was present in 38.75% of cases with tumors ≤8 mm.…”

Section: Discussionmentioning

confidence: 61%

Clinical characteristics and ultrasonographic features for predicting central lymph node metastasis in clinically node‐negative papillary thyroid carcinoma without capsule invasion

Yao

Zhou

et al. 2019

Head & Neck

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Background To evaluate the association of preoperative clinical and sonographic features with central lymph node metastasis (CLNM) in patients with clinically node‐negative (cN0) papillary thyroid carcinoma (PTC) without capsule invasion. Methods Clinical and sonographic features of 635 cN0 PTC nodules without capsule invasion were retrospectively reviewed. CLNM was confirmed by pathology. Univariate and multivariate analyses were performed to analyze the predicting factors associated with CLNM in cN0 PTC without capsule invasion. Results In the 635 cN0 PTC nodules without capsule invasion, age ≤36 years, male, tumor size >8 mm, the distance between the tumor and the capsule ≤1.1 mm and calcification were independently associated with CLNM (P < .05). Conclusions CLNM was associated with age, sex, tumor size, the distance between the tumor and the capsule, and calcification in cN0 PTC without capsule invasion. Preoperative assessment of risk factors could help to select PTC patients who benefit from surgery.

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Section: Discussionmentioning

confidence: 61%

Clinical characteristics and ultrasonographic features for predicting central lymph node metastasis in clinically node‐negative papillary thyroid carcinoma without capsule invasion

Yao

Zhou

et al. 2019

Head & Neck

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“…The role of pCND in cN0 PTC patients is controversial, with the current ATA guidelines not recommending routine pCND [ 22 ].The reason for this is that although performing pCND could detect occult CLNM, it has not been associated with improvement in recurrence or survival rates [ 23 – 25 ]. Additionally, patients undergoing central compartment neck dissection have been shown to suffer greater rates of morbidity, such as hypocalcemia and vocal cord paralysis, and there was also a cost-effectiveness disadvantage in comparison to patients who underwent total thyroidectomy alone [ 25 – 27 ]. Thus, a more selective approach is necessary to determine the requirement for pCND in patients with PTC.…”

Section: Discussionmentioning

confidence: 99%

Significance of distance between tumor and thyroid capsule as an indicator for central lymph node metastasis in clinically node negative papillary thyroid carcinoma patients

et al. 2018

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The aim of this study was to evaluate preoperatively identifiable clinical and ultrasonographic characteristics associated with central lymph node metastasis (CLNM) in clinically node negative papillary thyroid carcinoma (PTC) patients. Records of the patients who underwent thyroidectomy with prophylactic central lymph node dissection due to clinically node negative PTC (size, 1.0–3.0 cm) were reviewed. Of a total of 174 patients, 71 (40.8%) had CLNMs. CLNM was more associated with capsule invasion than capsule non-invasion on ultrasonography (68.4% vs. 37.4%, p = 0.009). In the 155 patients without capsule invasion, a distance from the capsule < 1.9 mm was associated with CLNM in univariable (p = 0.002) and multivariable analysis (p < 0.001). Any PTC patient with a distance from the capsule ≥ 1.9 mm did not have CLNM whereas 40.8% (58/142) of PTC patients with a distance from the capsule < 1.9 mm had CLNM. CLNM was not associated with age, gender, or tumor size on ultrasonography. Distance from capsule ≥ 1.9 mm on preoperative ultrasonography was a significant indicator for not having CLNM in clinically node negative PTC patients. Measuring distance from the capsule on preoperative ultrasonography images could help select patients with PTC who could benefit from prophylactic central lymph node dissection.

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“…When determining the surgical extent for PTC, surgical complications should be considered. Thyroidectomy has an increased a risk of hypoparathyroidism and recurrent laryngeal nerve injury compared with hemithyroidectomy . In this study, the incidence of hypoparathyroidism and vocal cord paralysis in the hemithyroidectomy group was significantly lower than those in the thyroidectomy group.…”

Section: Discussionmentioning

confidence: 53%

Extent of surgery did not affect recurrence during 7‐years follow‐up in papillary thyroid cancer sized 1‐4 cm: Preliminary results

Kim

Lee²,

Lee³

et al. 2017

Clinical Endocrinology

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Incidence of permanent hypocalcaemia after total thyroidectomy with or without central neck dissection for thyroid carcinoma: a nationwide claim study

Abstract: TT plus CND was associated with a greater risk of permanent hypocalcaemia than TT alone. Surgeons should consider the risk of permanent hypocalcaemia when deciding whether to perform CND.

Cited by 26 publications

References 34 publications

Clinical characteristics and ultrasonographic features for predicting central lymph node metastasis in clinically node‐negative papillary thyroid carcinoma without capsule invasion

Clinical characteristics and ultrasonographic features for predicting central lymph node metastasis in clinically node‐negative papillary thyroid carcinoma without capsule invasion

Significance of distance between tumor and thyroid capsule as an indicator for central lymph node metastasis in clinically node negative papillary thyroid carcinoma patients

Extent of surgery did not affect recurrence during 7‐years follow‐up in papillary thyroid cancer sized 1‐4 cm: Preliminary results

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