Incidence of peptic ulcer disease in Gothenburg, 1985.

Schöön, Ivi-Mai; Mellström, Dan; Odén, Anders; Ytterberg, Bengt-Olof

doi:10.1136/bmj.299.6708.1131

Cited by 27 publications

(10 citation statements)

References 30 publications

(2 reference statements)

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“…We reported the percentage of gastric ulcers as 6.7% who underwent OGD for dyspepsia .The overall frequency of gastric ulcer in the studied population was 6.7% as compared to duodenal ulcer which was 4% in our study, the ratio of duodenal ulcer was 0.5: 1 not in concordance with the published by Khalid Mahmood et al [11]in which overall frequency of duodenal ulcer with that of gastric ulcer was 8.1% versus 3.7% .The reverse duodenal ulcer to gastric ulcer ratio was reported in our study and ,was also reported from Multan [22] ,Japan and South America [23,24,25] .Gastric ulcer occurs mostly in the sixth decade in the European countries .In this study mean age was 45 years supporting the view that in India these diseases occur at an earlier age [26].…”

Section: Discussionsupporting

confidence: 85%

Upper Gastro Instestinal Endoscopic Findings In Patients With Dyspepsia: Our Experience At Cims, Bilaspur, Chhattisgarh, India

Khan¹,

Mohanty²,

Kumar³

et al. 2014

IOSRJDMS

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Objective:Aim of the study was to evaluate Upper Gastro Intestinal endoscopic findings in patients presenting with dyspepsia and to campare with earlier studies. Material and Method:This retrospective, observational study was conducted in endoscopic unit in the Department of Medicine in chhattisgarh institute of medical sciences, fromJuly 2007 to December 2011. Adult patients with dyspepsia who underwent Upper Gastro Intestinal endoscopies where included in the studies. Patients were referred by the consultants and doctors working in the periphery for endoscopy. Endoscopies were performed as per standard protocol with diagnoses based on accepted criteria. Results: Upper Gastro Intestinal endoscopies were performed on a total of 593 patients. Patients who presented with dyspepsia were scoped. Amongst them 64.9% (n=385) were male and 35.1 %(n=208) were females. The mean age of the studied population was 41.45 years (SD +_ 15.343), most common lesion was gastritis seen in 25.1 %(n=149), esophagitis 3.5 %(n=21), gastric carcinoma 4.6% (n=27), esophageal carcinoma 3.7% (n=22), gastric ulcer 6.7% (n=40) duodenal ulcer was found in 4 %(n=24). Gastric ulcer was more common as compared to duodenal ulcer (6.7% vs. 4%).Endoscopy was normal in 40.0% (n=237) of the patients. Conclusion: Endoscopy is a very important investigative modality to identify the specific pathology in patients of dyspepsia .Gastritis; Esophagitis, Duodenitis, Duodenal ulcer,Gastric ulcer, Gastric carcinomas and esophageal carcinoma were the commonest endoscopic diagnostic findings.

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Section: Discussionsupporting

confidence: 85%

Upper Gastro Instestinal Endoscopic Findings In Patients With Dyspepsia: Our Experience At Cims, Bilaspur, Chhattisgarh, India

Khan¹,

Mohanty²,

Kumar³

et al. 2014

IOSRJDMS

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“…Table VI shows the annual ulcer incidence per 1000 persons at risk in similar studies.1 [28][29][30][31][32][33][34][35][36] Comparing our findings to previous Danish studies28-30 suggests that the incidence of duodeno-pyloric ulcer seems to be unchanged in women but decreasing in men while the incidence of gastric ulcer could be increasing in both sexes (Table VI). Compared with international studies our results are in accordance with most recent reports.…”

Section: Discussionsupporting

confidence: 68%

Prevalence and incidence of peptic ulcer disease in a Danish County--a prospective cohort study.

Rosenstock

Jørgensen

1995

Gut

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Peptic ulcer prevalence and five year incidence were assessed in a sex and age stratified population sample of 3608 Danish subjects aged 30-60 years. Statements of peptic ulcer disease obtained from questionnaires were scrutinised by reviewing medical records. Life time ulcer prevalence (95%/o confidence intervals) was 5.6 (4.9-6.4) per cent. Male to female prevalence ratio was 22:1, and duodenal to gastric ulcer prevalence ratio was 3.8:1. Thirty two participants with no previous history of peptic ulceration developed an ulcer within the observation period resulting in a five year ulcer incidence of 11.3 (7.4.15.2) per 1000 persons at risk with no demonstrable sex difference. The prevalence of duodenal ulcer has declined in Denmark whereas gastric ulcer prevalence in men has increased slightly. A decline in male duodenal ulcer incidence has probably contributed to the low male to female ulcer incidence ratio, implying that women today incur the same risk of developing an ulcer as men. continue, they will bring about a new era in ulcer epidemiology characterised by equal incidence in men and women and an even distribution of lesions in the stomach and duodenum. (Gut 1995; 36: 819-824) Keywords: peptic ulcer, duodenal ulcer, gastric ulcer, epidemiology, prevalence, incidence.Since the mid-twentieth century peptic ulcer mortality in Westernised countries has declined in young and middle aged subjects. Ulcer mortality in senior citizens has, none the less, remained essentially unchanged or even increased.' Similar trends have been seen when other frequency estimates of ulcer occurrence such as hospitalisation, operation, and physician visit rates have been reviewed.2 Assessment of true peptic ulcer rates do, however, pose several methodological problems.3 Preferably prevalence and incidence rates should be based only on cases verified by endoscopy, roentgenograms or surgery. Gastric and duodenal ulcer rates should be reported separately and ulcer incidence calculated exclusively from first time verified lesions.As ulcers are present intermittently, simply performing endoscopies on a representative sample of subjects does not ensure valid estimates of ulcer occurrence. Consequently, most previous studies have used hospitalisation rates and mortality as approximate measures of overall ulcer occurrence. Those findings are probably impaired by selection bias. Self reported ulcer occurrence likewise could be prone to bias. Provided that an unselected population is used, however, such an approach does have several advantages making it the most suitable means of determining the prevalence and incidence of peptic ulceration.This study reports the lifetime prevalence and five year incidence of peptic ulcer disease in an unselected Danish population. Ulcer incidence was computed exclusively from ulcer episodes occurring among participants with no previous history of peptic ulceration at study entry. Furthermore, ulcers were classified according to location whenever possible. Index cases were those who claimed tha...

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“…Gastric ulcer was defined by the demonstration of substantial depth to an ulcer crater that extended beyond the muscularis mucosa. 36 Patients with malignant gastric ulcer were not included in the present study. Gastric erosion was defined as a gastric mucosal defect without an ulcer crater.…”

Section: Patientsmentioning

confidence: 99%

Prevalence of gastric ulcer in cirrhotic patients and its relation to portal hypertension

Chen

Hwang

et al. 1996

J of Gastro and Hepatol

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The prevalence of gastric ulcer and its relationship to the severity of cirrhosis and degree of portal hypertension was evaluated in 245 cirrhotic patients, and compared with 245 age- and sex-matched healthy subjects. Portal and systemic haemodynamic studies were performed in cirrhotic patients. The prevalence of gastric ulcer in cirrhotic patients was 20.8%, which was significantly higher than the 4.0% found in healthy controls. Using a multivariate logistic regression model, the hepatic venous pressure gradient was found to be the only predictor of the prevalence of gastric ulcer in cirrhotic patients to present with gastric ulcer. The hepatic venous pressure gradient was significantly higher in cirrhotic patients with gastric ulcer than in those without (17.3 +/- 4.4 vs 15.5 +/- 5.0 mmHg, P = 0.01). Other variables, including sex, smoking, cardiac output and severity or aetiology of cirrhosis did not show significant differences between the two patient groups. The prevalence of gastric ulcer in cirrhotic patients whose hepatic venous pressure gradient was below 12 mmHg (4.5%) was similar to that observed in the healthy controls (4.0%). However, when the hepatic venous pressure gradient was > 12 mmHg, the prevalence of gastric ulcer (24.4%) was significantly higher than that in control subjects. However, the incidence of gastric ulcer was not related to the degree of portal hypertension. In conclusion, the prevalence of gastric ulcer in cirrhotic patients was found to be significantly higher than in the age- and sex-matched healthy subjects. Portal hypertension with a hepatic venous pressure gradient > 12 mmHg may be an important factor contributing to the increased prevalence of gastric ulcer observed in patients with liver cirrhosis.

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Incidence of peptic ulcer disease in Gothenburg, 1985.

Cited by 27 publications

References 30 publications

Upper Gastro Instestinal Endoscopic Findings In Patients With Dyspepsia: Our Experience At Cims, Bilaspur, Chhattisgarh, India

Upper Gastro Instestinal Endoscopic Findings In Patients With Dyspepsia: Our Experience At Cims, Bilaspur, Chhattisgarh, India

Prevalence and incidence of peptic ulcer disease in a Danish County--a prospective cohort study.

Prevalence of gastric ulcer in cirrhotic patients and its relation to portal hypertension

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