Incidence of Noninfectious Conditions in Perinatally HIV-Infected Children and Adolescents in The HAART Era

Abstract

Objective: To estimate highly active antiretroviral therapy (HAART)-era incident rates for the first episode of noninfectious conditions in human immunodeficiency virus (HIV)-infected youth in order to identify HAART-era changes in the natural history of perinatal HIV infection.Design: Multicenter prospective cohort study. Conclusions: Between 2001 and 2006, the incidence for 3 conditions decreased and increased for 2 others, demonstrating the change in medical issues and conditions in perinatally infected youth. Continued surveillance with appropriate tools will be needed to assess the long-term effects of HAART and HIV as well as development of new noninfectious conditions of HIV.

Stavudine Induced Acute Pancreatitis in Paediatric Human Immunodeficiency Virus Infection

“…Patients infected with HIV are 35 to 800 times more likely to develop AP than the general population. In a recent multicentric study of 2575 HIV-infected children, among the incidence of non infectious conditions, pancreatitis constitutes approximately 0.30% [3]. Antiretroviral agents linked to AP include nucleoside reverse transcriptase inhibitors (NRTI) and protease inhibitors (PI).…”

Dynamics of Clinical Laboratory Parameter in Hiv-Infected Children Undergoing Different Patterns of Initial Highly Active Antiretroviral Therapy: Randomized Controlled Trial

“…Важность назначения высокоактивной антиретрови-русной терапии (ВААРТ) определяется неблагоприятным течением ВИЧ-инфекции у детей, быстрым развитием иммуносупрессии, приводящей к присоединению тяже-лых оппортунистических инфекций, развитию злокаче-ственных опухолей и в конечном итоге к летальному исхо-ду [1,2]. ВААРТ позволяет подавить репликацию вируса иммунодефицита человека (ВИЧ), о чем свидетельствует снижение уровня вирусемии (вирусной нагрузки кро-ви, ВНК) < 50 копий/мл.…”

Clinical Manifestations of HIV-Infection in the Era of Highly Active Antiretroviral Therapy

“…As survival has been prolonged in perinatally HIV-infected children and adolescents in the HAART era and many of them are now reaching adulthood, an increase in the incidence rates over time in pregnancy-related conditions and gynaecological dysplasia is being observed in parallel with a decrease of the incidence of the other non infectious conditions. (Nachman et al, 2009) (CDC 1993) www.intechopen.com…”