Incidence of neural tube defects in the least-developed area of India: a population-based study

Cherian, Anil; Seena, Siju; Bullock, Robyn K; Antony, Asok

doi:10.1016/s0140-6736(05)67319-9

Cited by 99 publications

(86 citation statements)

References 7 publications

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“…The prevalence of neural tube defects (0.51 ‰) was comparatively lower as against those from other Indian studies where it ranged from 0.84 to 8.8 ‰ (Verma et al 1998;Bharucha 1998;Cherian et al 2005). Like CHD and Down syndrome, the risk of neural tube defects in the present study appears to be higher among female births, although not statistically significant.…”

Section: Discussioncontrasting

confidence: 78%

Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India

et al. 2012

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Monitoring newborns for adverse outcomes like stillbirth and major congenital anomalies (MCA) is being carried out in government hospitals since 1995 in and around high-level natural radiation areas, a narrow strip of land on the southwest coast of Kerala, India. Natural deposits of monazite sand containing thorium and its daughter products account for elevated levels of natural radiation. Among 141,540 newborns [140,558 deliveries: 139,589 singleton, 957 twins (6.81 ‰), 11 triplets (0.078 ‰), and one quadruplet] screened, 615 (4.35 ‰) were stillbirth and MCA were seen in 1,370 (9.68 ‰) newborns. Clubfoot (404, 2.85 ‰) was the most frequent MCA followed by hypospadias (152, 2.10 ‰ among male newborns), congenital heart disease (168, 1.19 ‰), cleft lip/palate (149, 1.05 ‰), Down syndrome (104, 0.73 ‰), and neural tube defects (72, 0.51 ‰). Newborns with MCA among stillbirths were about 20-fold higher at 190.24 ‰ (117/615) compared to 8.89 ‰ (1,253/140,925) among live births (P<.001). Logistic regression was carried out to compare stillbirth, overall, and specific MCA among newborns from areas with dose levels of ≤1.5, 1.51-3.0, 3.01-6.0 and >6 mGy/year after controlling for maternal age at birth, gravida, consanguinity, ethnicity, and gender of the baby. Clubfoot showed higher prevalence of 3.26 ‰ at dose level of 1.51-3.0 mGy/year compared to 2.33 ‰ at ≤1.5 mGy/ year (OR01.39; 95 % CI, 1.12-1.72), without indication of any clear dose-response. Prevalences of stillbirth, overall MCA, and other specific MCA were similar across different dose levels and were relatively lower than that reported elsewhere in India, probably due to better literacy, health awareness, and practices in the study population.

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Section: Discussioncontrasting

confidence: 78%

Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India

et al. 2012

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“…Poultry meat and its products have a vast consumer market and are making a significant contribution to the supply of quality protein (Mothershaw et al, 2009), vitamins, and minerals (Waskar et al, 2009). The incidence of several common metabolic diseases associated with deficiencies of critical dietary minerals, vitamins, and amino acids can be reduced by consuming poultry products because they are rich in all essential nutrients (Cherian, Seena, Bullock, & Antony, 2005). Chicken meat products can be considered an important component in healthy diets (Jahan, Paterson, & Spickett, 2004), as they contain a higher proportion of polyunsaturated fatty acids compared with meat from other species (Berzaghi, Dalle Zotte, Jansson, & Andrighetto, 2005), high nutritional value, and distinct flavor (Patsias, Badeka, Savvaidis, & Kontominas, 2008).…”

Section: Introductionmentioning

confidence: 99%

Microbial and oxidation characteristics of refrigerated chicken patty incorporated with moringa (Moringa oleifera) leaf powder

Elhadi

Elgasim

Ahmed

2016

CyTA - Journal of Food

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This study investigated the effect of different levels of Moringa oleifera leaf powder (MLP) on physicochemical, microbiological, and sensory characteristics of chicken patties during cold storage. For MLP extracts, methanolic extract exhibited flavonoid and total phenolic contents of 48.0 and 2010.3 mg/kg, respectively. The aqueous extract of MLP showed high (16.7 mm) and mild (8.7 mm) antimicrobial activity (inhibition zones) against Escherichia coli and Staphylococcus aureus, respectively. In chicken patties, the pH, peroxide value (PV), sensory properties, and microbiological characteristics were all affected (P ≤ 0.05) by the incorporation of MLP into the patty formula. The PV and bacterial counts were decreased (P ≤ 0.05) with the increase in MLP concentration; however, their values were increased (P ≤ 0.05) with the progress of storage period. Moderate level (50 g/kg) of MLP was good (P ≤ 0.05) in retarding lipid peroxidation and inhibiting microbial growth without affecting the sensory quality of stored chicken patties.Características microbianas y oxidativas de la hamburguesa de pollo refrigerada con moringa en polvo (Moringa oleifera) RESUMENEste estudio investigó el efecto de diferentes niveles de Moringa oleifera en polvo (MLP) en las características fisicoquímicas, microbiológicas y sensoriales de hamburguesas de pollo durante su almacenamiento en frío. En los extractos de MLP, el extracto de metanol exhibió contenidos de flavonoides y total fenólico de 48,0 mg/kg y 2010,3 mg/kg, respectivamente. El extracto acuoso de MLP mostró niveles altos (16,7 mm) y medianos (8,7 mm) de actividad antimicrobiana (zonas de inhibición) frente a Escherichia coli y Staphylococcus aureus, respectivamente. En las hamburguesas de pollo, el pH, el índice de peróxido (PV), las propiedades sensoriales y las características microbiológicas se vieron todos afectados (P ≤ 0,05) por la incorporación de MLP en la fórmula de la hamburguesa. El PV y los recuentos bacterianos disminuyeron (P ≤ 0,05) con el aumento de la concentración de MLP, sin embargo, sus valores aumentaron (P ≤ 0,05) con el progreso del periodo de almacenamiento. El nivel moderado (50 g/kg) de MLP fue favorable (P ≤ 0,05) para retardar la peroxidación lipídica e inhibir el crecimiento microbiano sin afectar la calidad sensorial de las hamburguesas de pollo almacenadas. ARTICLE HISTORY

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“…1,2 In parts of India and China the incidence is particularly high: around 6 per 1000 live births 3 compared with 1 per 1000 in Europe. 1 Before use of the cerebrospinal fluid (CSF) shunts in the 1960s, most children with spina bifida and hydrocephalus died in infancy.…”

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confidence: 99%

Expectation of life and unexpected death in open spina bifida: a 40‐year complete, non‐selective, longitudinal cohort study

Oakeshott

Hunt

Poulton

et al. 2010

Develop Med Child Neuro

147

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AIM The aim of our study was to investigate survival and causes of death in a complete cohort of open spina bifida at the mean age of 40 years.METHOD We conducted a community-based, prospective study of 117 consecutive infants (50 males, 67 females) with open spina bifida whose backs were closed non-selectively within 48 hours of birth between 1963 and 1971 at Addenbrooke's Hospital, Cambridge, UK. Of those who survived to age 1 year, 89% (82 out of 92) had a cerebrospinal fluid shunt. In 2007, all survivors were surveyed by postal questionnaire backed up by telephone interview. Details of deaths were obtained from the Office for National Statistics, medical records, and autopsy reports, and Kaplan-Meier survival curves were constructed.RESULTS One in three of the cohort (40 ⁄ 117) died before the age of 5 years. A further 26%(31 ⁄ 117) died during the next 35 years, over 10 times the national average. Half the deaths (16 ⁄ 31) after the age of 5 were sudden and unexpected. All occurred in the community and were followed by a coroner's autopsy. The most frequent causes of these unexpected deaths were epilepsy, pulmonary embolus, acute hydrocephalus, and acute renal sepsis. The prognosis for survival was strikingly poor in those with the most extensive neurological deficit. Only 17% (7 ⁄ 42) of those born with a high sensory level (above T11) survived to the mean age of 40 years, compared with 61% (23 ⁄ 38) of those with a low sensory level (below L3; p=0.001).INTERPRETATION Doctors and care planners need to be aware that, contrary to previous suggestions, there is continuing high mortality throughout adult life in individuals with open spina bifida, and many deaths are unexpected.

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Incidence of neural tube defects in the least-developed area of India: a population-based study

Cited by 99 publications

References 7 publications

Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India

Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India

Microbial and oxidation characteristics of refrigerated chicken patty incorporated with moringa (Moringa oleifera) leaf powder

Expectation of life and unexpected death in open spina bifida: a 40‐year complete, non‐selective, longitudinal cohort study

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