Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India

Jaikrishan, G.; Sudheer, K. R.; Andrews, V. J.; Koya, P. K. M.; Madhusoodhanan, M.; Jagadeesan, C. K.; Seshadri, M.

doi:10.1007/s12687-012-0113-1

Cited by 40 publications

(24 citation statements)

References 29 publications

(36 reference statements)

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“…Nineteen studies that reported on prevalence of NTD among 547,803 new-borns were included. The birth prevalence of NTDs reported ranged from 0.5 per 1000 total births [ 22 ] to 18.2 per 1000 total births [ 13 ]. All the studies included in the meta-analysis were hospital based studies except one.…”

Section: Resultsmentioning

confidence: 99%

“…Results from two studies [ 21 , 22 ] with gender specific prevalence of NTDs, shows the pooled prevalence of 2.3 cases per 1000 male births (95% CI 0.45 to 5.14) and 4.3 cases per 1000 female births (95% CI 1.90 to 10.41). There was no statistical evidence that NTD prevalence was higher in any gender.…”

Section: Resultsmentioning

confidence: 99%

“…There were two studies [ 22 , 29 ] which reported gender specific prevalence of the OFCs in India. The pooled prevalence of OFCs among male births was 0.6 per 1000 total births and 0.53 per 1000 among female total births.…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, we carried out a sub group analysis for prevalence of OFCs across the regions of India. The pooled prevalence in the Southern region [ 18 , 20 , 22 ] was 1.1 per 1000 total births (95% CI 0.3 to 1.9), and in the Western region [ 24 , 25 , 27 ] it was 1.8 per 1000 total births (95% CI 1.5 to 2.1). In the Eastern region [ 29 ] there was only one study reporting the prevalence of OFCs which was 0.70 per 1000 total births (95% CI 0.67 to 0.73).…”

Section: Resultsmentioning

confidence: 99%

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Birth Prevalence of Neural Tube Defects and Orofacial Clefts in India: A Systematic Review and Meta-Analysis

et al. 2015

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BackgroundIn the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and orofacial clefts in India have reported inconsistent results. Therefore, we conducted a systematic review of observational studies to document the birth prevalence of neural tube defects and orofacial clefts.MethodsA comprehensive literature search for observational studies was conducted in MEDLINE and EMBASE databases using key MeSH terms (neural tube defects OR cleft lip OR cleft palate AND Prevalence AND India). Two reviewers independently reviewed the retrieved studies, and studies satisfying the eligibility were included. The quality of included studies was assessed using selected criteria from STROBE statement.ResultsThe overall pooled birth prevalence (random effect) of neural tube defects in India is 4.5 per 1000 total births (95% CI 4.2 to 4.9). The overall pooled birth prevalence (random effect) of orofacial clefts is 1.3 per 1000 total births (95% CI 1.1 to 1.5). Subgroup analyses were performed by region, time period, consanguinity, and gender of newborn.ConclusionThe overall prevalence of neural tube defects from India is high compared to other regions of the world, while that of orofacial clefts is similar to other countries. The majority of studies included in the review were hospital based. The quality of these studies ranged from low to moderate. Further well-designed, high quality community-based observational studies are needed to accurately estimate the burden of neural tube defects and orofacial clefts in India.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Birth Prevalence of Neural Tube Defects and Orofacial Clefts in India: A Systematic Review and Meta-Analysis

et al. 2015

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“…The condition can be surgically repaired in some cases, but requires special care of the infant to prevent choking or aspiration until the surgery can be performed. Among the risk factors identified for cleft palate/lip are environmental pollutants, including radiation exposure [55]. Down syndrome, also Trisomy-21, features growth delays, similar facial and hand features and substantial intellectual deficits.…”

Section: Introductionmentioning

confidence: 99%

Changes in Congenital Anomaly Incidence in West Coast and Pacific States (USA) after Arrival of Fukushima Fallout

Mangano¹,

Sherman²

2015

OJPed

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Radioactive fallout after the March 2011 Fukushima nuclear meltdown entered the U.S. environment within days; levels of radioactivity were particularly elevated in the five western states bordering on the Pacific Ocean. The particular sensitivity of the fetus to radiation exposure, and the ability of radioisotopes to attach to cells, tissues, and DNA raise the question of whether fetuses/newborns with birth defects with the greater exposures suffered elevated harm during the period after the meltdown. We compare rates of five congenital anomalies for 2010 and 2011 births from April-November. The increase of 13.00% in the five western states is significantly greater than the 3.77% decrease for all other U.S. states combined (CI 0.030-0.205, p < 0.008). Consistent patterns of elevated increases are observed in the west (20 of 21 comparisons, 6 of which are statistically significant/borderline significant), by state, type of birth defect, month of birth, and month of conception. While these five anomalies are relatively uncommon (about 7500 cases per year in the U.S.), sometimes making statistical significance difficult to achieve, the consistency of the results lend strength to the analysis, and suggest fetal harm from Fukushima may have occurred in western U.S. states.

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Birth prevalence of achondroplasia: A systematic literature review and meta‐analysis

Foreman

Kessel²,

Hoorn³

et al. 2020

American J of Med Genetics Pt A

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Achondroplasia is a genetic disorder that results in disproportionate short stature. The true prevalence of achondroplasia is unknown as estimates vary widely. This systematic literature review and meta‐analysis was conducted to better estimate worldwide achondroplasia birth prevalence. PubMed, Embase, Scielo, and Google Scholar were searched, complemented by manual searching, for peer‐reviewed articles published between 1950 and 2019. Eligible articles were identified by two independent researchers using predefined selection criteria. Birth prevalence estimates were extracted for analysis, and the quality of evidence was assessed. A meta‐analysis using a quality effects approach based on the inverse variance fixed effect model was conducted. The search identified 955 unique articles, of which 52 were eligible and included. Based on the meta‐analysis, the worldwide birth prevalence of achondroplasia was estimated to be 4.6 per 100,000. Substantial regional variation was observed with a considerably higher birth prevalence reported in North Africa and the Middle East compared to other regions, particularly Europe and the Americas. Higher birth prevalence was also reported in specialized care settings. Significant heterogeneity (Higgins I2 of 84.3) was present and some indication of publication bias was detected, based on visual asymmetry of the Doi plot with a Furuya‐Kanamori index of 2.73. Analysis of pooled data from the current literature yields a worldwide achondroplasia birth prevalence of approximately 4.6 per 100,000, with considerable regional variation. Careful interpretation of these findings is advised as included studies are of broadly varying methodological quality.

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Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India

Cited by 40 publications

References 29 publications

Birth Prevalence of Neural Tube Defects and Orofacial Clefts in India: A Systematic Review and Meta-Analysis

Birth Prevalence of Neural Tube Defects and Orofacial Clefts in India: A Systematic Review and Meta-Analysis

Changes in Congenital Anomaly Incidence in West Coast and Pacific States (USA) after Arrival of Fukushima Fallout

Birth prevalence of achondroplasia: A systematic literature review and meta‐analysis

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