Incidence of mammary tumors in the canine population living in the Veneto region (Northeastern Italy): Risk factors and similarities to human breast cancer

Vascellari, Marta; Capello, Katia; Carminato, Antonio; Zanardello, Claudia; Baioni, Elisa; Mutinelli, Franco

doi:10.1016/j.prevetmed.2016.02.008

Cited by 91 publications

(91 citation statements)

References 33 publications

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“…It's important to emphasize the high amount of bitches affected by CMT who carry one to three SNPs in BRCA2 exon 11 identified in this work (97.9%), which suggests a correlation between these gene polymorphisms and mammary carcinogenesis. Moreover, the vast majority of mammary tumors identified in this study were malignant (95.8%), revealing a higher incidence than reported by other authors which show a range of 47.5% to 83.0% of malignancy …”

Section: Discussioncontrasting

confidence: 47%

Common germline haplotypes and genotypes identified in BRCA2 exon 11 of dogs with mammary tumours and histopathological analyses

Maués

El-Jaick

Costa

et al. 2018

Vet Comparative Oncology

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Funding informationCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) of the Brazilian Ministry of Education The canine BRCA2 is a tumor supressor gene which encodes the BRCA2 protein, involved in DNA repair through interaction with the RAD51 recombinase. This process is mediated by eigth BRC repeats that are encoded by BRCA2 exon 11. Two variants corresponding to human mutations in human BRC3 repeat have been reported in canine BRC3 repeat. In addition, other variants have also been described in canine BRCA2 exon 11. Considering the importance of polymorphisms in human BRCA2 to breast cancer development, this study aimed to investigate the frequency of variants in BRCA2 exon 11 in 48 blood and tissue DNA samples from bitches with canine mammary tumors (CMT), as well as, to analyze tumor stage and histopathological features. Seven Single Nucleotide Polymorphisms (SNPs) were identified, three of which were evaluated as possibily or probably deleterious variant.Interestingly, almost all the 22 mammary tumors (except one) which presented a clinical staging equal to or greater than III carried at least one mutant allele of these three variants.Besides that, no statistically significant correlation was observed between any of the reported SNPs in heterozygosis or homozygosis and either dogs data (such as breed, age or disease stage) or mammary tumors histopathological characteristics. A total of 97.9% of bitches had one to three polymorphisms of the seven identified in this study, which suggests a possibly correlation between the canine BRCA2 exon 11 polymorphisms and mammary carcinogenesis. K E Y W O R D SBRCA2, breast cancer, canine, carcinogenesis, RAD51

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Section: Discussioncontrasting

confidence: 47%

Common germline haplotypes and genotypes identified in BRCA2 exon 11 of dogs with mammary tumours and histopathological analyses

Maués

El-Jaick

Costa

et al. 2018

Vet Comparative Oncology

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“…The canine mammary carcinoma, as well as other types of canine mammary tumors, has an incidence rate and clinical and epidemiological characteristics comparable to breast tumors in women (Vascellari et al, 2016). Being unusual occurrence, case reports as the breast carcinosarcoma canine extend the cytogenetic knowledge in veterinary and human areas.…”

Section: Discussionmentioning

confidence: 92%

“…An epidemiological study conducted in northern Italy during the period 2005-2013 compared to breast cancer incidence in bitches with records of breast tumor incidence in women from the same region and data published worldwide (Vascellari et al, 2016). It was noted that in both cases, breast tumor in bitches and women, there is a sharing of several risk factors and similarities in the incidence rate that validates the use of breast tumor in bitches as an epidemiological model for breast tumor study in humans.…”

Section: Introductionmentioning

confidence: 83%

Cytogenetic aspects of a canine breast carcinosarcoma - a case report

Morais

Affonso²,

Bitencourt³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterations include chromosomal abnormalities that can be useful for the identification of tumoral cells and diagnosis. The aim of this study was to compare the chromosomal features of peripheral lymphocytes and tumor cells in a mammary carcinosarcoma of a 14-year-old female Poodle. Chromosomes were analyzed from 210 metaphases by conventional Giemsa staining, C-banding, and base-specific fluorochrome staining with chromomycin A3 (CMA 3 + ) and DAPI. Of the 105 blood cells, 56.3% followed the standard karyotype of dogs (2n = 78). In contrast, the carcinosarcoma cells showed high chromosomal numbers (104 to 153), divided into 80% hypertriploid (118 to 136 chromosomes), 10.5% hypotetraploid (137 to 153 chromosomes), 5.7% hypotriploid (104 to 116 chromosomes), and 3.8% triploid cells (117 chromosomes). Among the aneuploid cells identified, we highlighted the trisomy of pair 1 and X chromosome once these elements were easily recognized in karyotype because of their size (pair 1) or differential morphology. Heterochromatin in normal cells was restricted to the pericentromeric region of all chromosomes while few C-bands were observed in tumor cells. This apparent loss of heterochromatin in neoplastic cells was supposed to favor centric fusion among formerly acrocentric chromosomes. Fluorochrome staining reinforced this hypothesis once GC-rich segments (CMA 3 + ) were identified on 10 chromosomes from normal cells (2n = 78) whereas carcinosarcoma metaphases had up to 11 chromosomes bearing CMA 3 signals in spite of their remarkable high chromosomal numbers. We concluded that, like in humans, the carcinosarcoma in dogs caused genome instability that eventually led to structural and numerical chromosomal aberrations. Besides, this study reinforced the importance of cytogenetic studies in dogs as a reference material for human cancer studies, especially in rare cases, since it is possible to increase knowledge about the characteristics of breast neoplasms in which there is a little availability of similar cases for comparative studies.

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“…Das Lebenszeitrisiko von Frauen in Deutschland, Brustkrebs zu entwickeln, beträgt 12,9%, d.h. jede achte Frau ist betroffen [1]. In einer aktuellen Studie in Norditalien zeigte sich, dass canine Mammatumoren (CMT) die am häufigsten diagnostizierte Krebsart waren und innerhalb der Auswertungszeit 2005-2013 deutlich anstiegen [2]. In einer norwegischen Studie mit 14 401 Hunden wiesen 30% der Tiere CMT auf, von denen 95% maligne waren [3].…”

Section: Introductionunclassified

Postoperative adjuvante Therapie mit einem Mistelextrakt (Viscum album ssp. album) bei Hündinnen mit Mammatumoren

et al. 2017

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Keywords Canine mammary tumor · Mistletoe therapy · Viscum album · Adjuvant treatment · Veterinary medicine · Quality of life · Oncology Summary Postsurgical Adjuvant Treatment with Mistletoe Extract (Viscum album ssp. album) in Canine Mammary TumorsBackground: The high incidence rate and malignancy of canine mammary tumors (CMTs) and their treatment pose a challenge in veterinary practice. Postsurgical therapy is required. Currently, there is no established standardized postsurgical adjuvant therapy and such a therapy is not expected for the near future. Maintaining or increasing the dogs' quality of life (QL) and their tolerance of the treatment are of importance to the pet owner. Cancer treatment by using extracts of European mistletoe (Viscum album L.; VAE) is well introduced in human medicine. Besides tumor baseline therapy using radiation or chemotherapy, treatment with VAE is one of the most common adjuvant methods among complementary and alternative therapies. Also in veterinary oncology, Viscum preparations have been used successfully for many years in various species. A number of studies underlined the positive effects of mistletoe treatment in animals. Methods: In the present study, the effects and benefits of postsurgical adjuvant therapy with VAE in canine mammary adenocarcinomas were investigated. Additionally, effects on QL were analyzed. For this purpose, a total of 56 female dogs were enrolled in the study. Of these, 33 dogs served as retrospective control group whereas 23 dogs were assigned as prospective VAE treatment group. The latter started VAE after surgical tumor excision. Results: The median survival time (MST) for all involved dogs (n = 56) was 32 months (interquartile range 13-51 months). For the control group, Kaplan-Meier analysis showed survival of 24 (73%), 20 (61%), 15 (45%), and 5 dogs (12%) after 12, 24, 36, and 48 months, respectively. In the Viscum group, survival was 19 (83%), 14 (61%), 11 (48%), and 1 dog (4%), respectively. Multivariate Cox proportional hazard analysis resulted in a lower death risk after VAE treatment (hazard ratio (HR) 0.53, 95% confidence interval (CI) 0.22-1.26), which was not significantly different between the two groups (p = 0.151). An also not significant tendency of decrease in tumor-related death risk to 25% (HR 0.251, 95% CI 0.056-1.122; p = 0.07) was observed for the treatment group. Conclusions: The results indicate a tendency of lower tumor-related death risk after postsurgical adjuvant VAE therapy in female dogs suffering from CMTs. The QL was stable during the entire observation period and the therapy was well tolerated by the patients. (HR 0,251,122). Schlussfolgerungen: Es kann eine Tendenz zur Senkung des tumorbedingten Sterberisikos der VAEGruppe bei guter Verträglichkeit der Therapie angenommen werden. Die LQ der Tiere blieb über die gesamte Beobachtungszeit auf hohem Niveau stabil.

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Incidence of mammary tumors in the canine population living in the Veneto region (Northeastern Italy): Risk factors and similarities to human breast cancer

Cited by 91 publications

References 33 publications

Common germline haplotypes and genotypes identified in BRCA2 exon 11 of dogs with mammary tumours and histopathological analyses

Common germline haplotypes and genotypes identified in BRCA2 exon 11 of dogs with mammary tumours and histopathological analyses

Cytogenetic aspects of a canine breast carcinosarcoma - a case report

Postoperative adjuvante Therapie mit einem Mistelextrakt (Viscum album ssp. album) bei Hündinnen mit Mammatumoren

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