Incidence of insulin-dependent diabetes mellitus among Sardinianheritage children born in Lazio region, Italy

Fonte, M.L.; Stoduto, S; Marietti, G.; Bizzarri, Carla; Crinò, Antonino; Ciampalini, Paolo; Multari, G; Suppa, M; Matteoli, M. C.; Lucentini, L; Sebastiani, L; Visalli, N; Pozzilli, Paolo; Boscherini, B; Muntoni, Sa.

doi:10.1016/s0140-6736(96)04241-9

Cited by 88 publications

(25 citation statements)

References 19 publications

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“…This finding, which is consistent with results of previous studies conducted in Lazio and in Lombardia 10,11 provides further evidence of a strong genetic effect on the pathogenesis of the disease in this population. In both previous studies, census data on children with Sardinian heritage allowed the estimation of incidence rates based on a reasonably large number of cases limited to this subgroup of patients.…”

Section: Discussionsupporting

confidence: 93%

Effect of Sardinian heritage on risk and age at onset of type 1 diabetes: a demographic case-control study of Sardinian migrants

Bruno¹

2000

International Journal of Epidemiology

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Section: Discussionsupporting

confidence: 93%

Effect of Sardinian heritage on risk and age at onset of type 1 diabetes: a demographic case-control study of Sardinian migrants

Bruno¹

2000

International Journal of Epidemiology

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“…Others observed that the risk did not differ greatly from that faced in the country of origin, a finding that is reinforced by our results, which bear great similarity to a recently published Sardinian study [11]. Children with Sardinian parents retained the same high incidence rate after emigrating to continental Italy and at no time during the observation period did the risk they faced drop A. Neu et al: Diabetes incidence in children of different nationalities B 24 Fig.…”

Section: Discussionsupporting

confidence: 90%

Diabetes incidence in children of different nationalities: an epidemiological approach to the pathogenesis of diabetes

et al. 2001

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“…Because similar increasing trends were found in two populations characterized by different genetic susceptibility, the role of shared environmental risk factors on these geographical area could be hypothesized (21).…”

Section: Trend Analysismentioning

confidence: 84%

Diabetes Incidence in 0- to 14-Year Age-Group in Italy

et al. 2004

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OBJECTIVE -The Registry for Type 1 Diabetes Mellitus in Italy (RIDI) Study Group was established to coordinate the registries of type 1 diabetes in Italy. This report is based on 3,606 children younger than 15 years diagnosed with type 1 diabetes and prospectively registered during 1990 -1999 by nine centers, covering Ͼ35% of the Italian population.RESEARCH DESIGN AND METHODS -Registries were pooled in four geographic macro-areas: north, central, south, and insular. The completeness of registration was assessed by the capture-recapture method. Poisson regression analysis was used to evaluate temporal trend in incidence.RESULTS -Large variations in incidence were confirmed not only between Sardegna and the mainland but also among peninsular areas. In Sardegna, there was an excess of boys (the boy-to-girl incidence ratio was 1.4). The overall incidence showed average increases of 3.6% (P Ͻ 0.001) and 3.7% (P Ͻ 0.001) per year in peninsular Italy and in Sardegna, respectively. Significant increases in incidence rates were found in boys aged 10 -14 years (6.7%, 95% CI 0.5-13.3) and in girls aged 5-9 years (6.6%, 0.5-13.1) living in the southern area. The incidence rate also increased in boys aged 10 -14 years (5.0%, 0.3-10) and in girls aged 0 -4 years (4.9%, 0.8 -9.1) living in Sardegna.CONCLUSIONS -Italy is a country with large geographical variations in incidence rates of type 1 diabetes. However, the rates are evenly increasing both in the mainland and Sardegna, suggesting that similar environmental factors are operating over populations that have different genetic backgrounds.

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Incidence of insulin-dependent diabetes mellitus among Sardinianheritage children born in Lazio region, Italy

Cited by 88 publications

References 19 publications

Effect of Sardinian heritage on risk and age at onset of type 1 diabetes: a demographic case-control study of Sardinian migrants

Effect of Sardinian heritage on risk and age at onset of type 1 diabetes: a demographic case-control study of Sardinian migrants

Diabetes incidence in children of different nationalities: an epidemiological approach to the pathogenesis of diabetes

Diabetes Incidence in 0- to 14-Year Age-Group in Italy

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