Diabetes incidence in children of different nationalities: an epidemiological approach to the pathogenesis of diabetes

Neu, Andreas; Willasch, André; Ehehalt, Stefan; Kehrer, Martin; Hub, R.; Ranke, Michael B.

doi:10.1007/pl00002948

Cited by 38 publications

(32 citation statements)

References 5 publications

(7 reference statements)

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“…Moreover, a variable pattern of increase in the same population is also observed, which might reflect ethnic differences (including both genetic and lifestyle factors) [14], differences in BMI [15], and area characteristics related to exposure to infections such as child population density, deprivation, urban-rural status, and remoteness [10]. In the present study, there were 2 peaks for age at diagnosis, one at 6 -6.5 years that is comparable to the peak of onset observed in other studies [16] and another at 9 -crease at puberty due to the associated sex effect [17].…”

Section: Discussionsupporting

confidence: 80%

Clinical Demographic Patterns of Type 1 Diabetes in Saudi Children in Tabuk City, 2000-2010

Albishi¹,

Altoonisi²,

Al-Blewi³

et al. 2017

JDM

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We aimed to identify the variation in the clinical background of children diagnosed with type 1 diabetes mellitus (T1DM) at King Salman Military Hospital (KSMH), Tabuk City, Kingdom of Saudi Arabia, from 2000 to 2010. Methods: This retrospective observational study was based on the clinical records of pediatric diabetes outpatients at KSMH. All children aged <12 years who were diagnosed with T1DM and were followed up at the diabetes clinic from 2000 to 2010, were enrolled. The local variables associated with the clinical presentation in these patients, including age, sex, body mass index (BMI), and season of onset, were evaluated. Results: Of 313 patients recruited, female patients were predominant (p = 0.002). The mean age of onset was 6.46 years (standard deviation, 3.02). One-third of the newly diagnosed patients were overweight (35.5%). Diabetic ketoacidosis (DKA) was the presenting feature in 38.0% of patients, wherein female patients and those aged 0 -3 years exhibited the highest likelihood of developing DKA (odds ratio, 1.7 and 2.9, respectively). Moreover, underweight children had a greater DKA incidence than healthy, overweight, or obese children (p = 0.02). Conclusion: This study provides additional data on T1DM in the population of the Kingdom of Saudi Arabia. In particular, we found a female predominance at presentation as well as 2 peaks for age at onset. Moreover, the BMI was lower in younger age groups overall, but was greater in older boys. Furthermore, the DKA rates were high in younger children. Thus, our data confirm the presence of variable clinical patterns in the Kingdom of Saudi Arabia, which requires further epidemiological analysis using national registry data.How to cite this paper: Albishi, L.A., Altoonisi, M.M., Alblewi, S.M., Osman, R.H., Ahmed, N

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Section: Discussionsupporting

confidence: 80%

Clinical Demographic Patterns of Type 1 Diabetes in Saudi Children in Tabuk City, 2000-2010

Albishi¹,

Altoonisi²,

Al-Blewi³

et al. 2017

JDM

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“…The percentage of children with type 1 diabetes who are not of German descent is smaller (8.3%) compared with the percentage among the general population (15.2%) (32). Causes for this observation are controversial (32). Therefore, incidence of diabetic complications could also be different in immigrant and non-immigrant children.…”

Section: Discussionmentioning

confidence: 99%

“…As one limitation of the present survey, no further data about health status, lifestyle or nutrition habits, socioeconomic parameters, and about the use of health care facilities were available. Another reason explaining the association between the development of microalbuminuria and immigrant status is the fact that incidence rates of type 1 diabetes in immigrant and nonimmigrant children are different (32). The percentage of children with type 1 diabetes who are not of German descent is smaller (8.3%) compared with the percentage among the general population (15.2%) (32).…”

Section: Discussionmentioning

confidence: 99%

“…Another reason explaining the association between the development of microalbuminuria and immigrant status is the fact that incidence rates of type 1 diabetes in immigrant and nonimmigrant children are different (32). The percentage of children with type 1 diabetes who are not of German descent is smaller (8.3%) compared with the percentage among the general population (15.2%) (32). Causes for this observation are controversial (32).…”

Section: Discussionmentioning

confidence: 99%

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Natural course of untreated microalbuminuria in children and adolescents with type 1 diabetes and the importance of diabetes duration and immigrant status: longitudinal analysis from the prospective nationwide German and Austrian diabetes survey DPV

Galler

Haberland²,

Näke³

et al. 2012

European Journal of Endocrinology

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Objective: To identify risk factors for the development and progression of untreated persistent microalbuminuria in children and adolescents with type 1 diabetes. Design and methods: A total number of 683 children and adolescents with type 1 diabetes recruited from the prospective nationwide German and Austrian diabetes survey (DPV) were included in the analysis. Inclusion criteria were onset of type 1 diabetes under the age of 11 years, diabetes duration of more than 1 year and continuous follow-up over 5 years with at least two documented urine analyses per year. Subjects treated with angiotensin-converting enzyme inhibitors were excluded. Risk factors such as sex, body mass index SDS, diabetes duration, HbA1c, total cholesterol, HDL-cholesterol, LDL-cholesterol, systolic and diastolic blood pressure, and immigrant status were analysed by logistic regression. Results: At baseline (age 10.5G0.1 years, diabetes duration 4.6G2.4 years and HbA1c 7.4G1.1%), 75.6% of children had normoalbuminuria, 15.7% had intermittent microalbuminuria, 8.6% had persistent microalbuminuria and 0.1% had macroalbuminuria. After a follow-up of 5 years, 59.4% of adolescents continued to have normoalbuminuria, 18.4% had progression, 15.2% had regression of microalbuminuria, and in 6.9% of the subjects, microalbuminuria remained unchanged. We found significant associations between persistent microalbuminuria at baseline and during each year of follow-up (P!0.0001). Logistic regression analysis identified diabetes duration and immigrant status as significant factors for microalbuminuria (PZ0.009 and PZ0.009). Conclusions: The survey in a real-world setting shows that diabetes duration and immigrant status are risk factors for the development and progression of untreated microalbuminuria in children and adolescents with type 1 diabetes.

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“…Durch die große Fallzahl ist das Konfidenzintervall eng und bewegt sich von 12,4-13,4. Die höchste jährliche Inzidenzrate wurde 1998 mit 15,6/100.000 (95% CI 13,[8][9][10][11][12][13][14][15][16][17]5) beobachtet, die niedrigste 1989 mit 9,2/100.000 (95% CI 7,7-10,7). Internationalen Einstufungskriterien zufolge gelten Regionen mit einer Inzidenz von mehr als 11,6/100.000 als "high risk area".…”

Section: Inzidenzunclassified

Häufigkeit des Diabetes mellitus im Kindesalter in Deutschland

Neu

Willasch

Ehehalt

et al. 2001

Monatsschrift Kinderheilkunde

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Diabetes incidence in children of different nationalities: an epidemiological approach to the pathogenesis of diabetes

Cited by 38 publications

References 5 publications

Clinical Demographic Patterns of Type 1 Diabetes in Saudi Children in Tabuk City, 2000-2010

Clinical Demographic Patterns of Type 1 Diabetes in Saudi Children in Tabuk City, 2000-2010

Natural course of untreated microalbuminuria in children and adolescents with type 1 diabetes and the importance of diabetes duration and immigrant status: longitudinal analysis from the prospective nationwide German and Austrian diabetes survey DPV

Häufigkeit des Diabetes mellitus im Kindesalter in Deutschland

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