Incidence of inflammatory bowel disease in Corsica from 2002 to 2003

“…Worldwide, strikingly, the high proportion of IBD-U was observed in the Netherlands[ 124 ] and the incidence of IBD cases is comparable with that reported in other European countries. In France, the incidence of CD significantly increased, while the incidence of UC remains unchanged from 1988 to 2011[ 32 , 43 , 125 - 128 ]. The most remarkable observation (the EPIMAD Registry) has been a striking increase from 1988 to 2008 in the incidence of CD (< 19 years)[ 125 ], and the rates also significantly rose from 1988 to 2011[ 32 , 126 , 127 ] Surprisingly, in Corsica, using the same registry (EPIMAD), the incidence of CD was close to that observed in other metropolitan French regions; however, the incidence of IBD for UC in Corsica is two-fold higher than that reported in other French regions[ 128 ].…”

Section: Discussionmentioning

confidence: 99%

Current global trends in the incidence of pediatric-onset inflammatory bowel disease

Sýkora

Pomahačová

Kreslová

et al. 2018

WJG

281

202

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AIMTo perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease (IBD).METHODSWe systematically searched the MEDLINE (source PubMed), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatric-onset (< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTSIn total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn’s disease (CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis (UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified (IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence (P < 0.05). The risk of IBD is increasing among first-generation of migrant populations.CONCLUSIONGlobally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts.

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“…Despite rare reports to the contrary 85, 86 , a north-south gradient of IBD is now well established for both CD and UC 87-94 , with risk positively correlated with latitude. In France, however, the effect of latitude was noted only for CD, not UC 91, 92 .…”

Section: Observational Studiesmentioning

confidence: 99%

Linking Vitamin D Deficiency to Inflammatory Bowel Disease

Palmer¹,

Weaver²

2013

Inflammatory Bowel Diseases

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Inflammatory bowel disease is associated with industrialization, and its incidence has increased markedly over time. The prospect of reversing these trends motivates the search for the agent(s) involved. Modernity entails several physical and behavioral modifications that compromise both the photosynthesis of cholecalciferol in the skin, and of its bioavailability. Although deficiency in this “vitamin” has therefore emerged as a leading candidate, and despite the publication of a randomized control trial that showed a trend towards statistically significant benefit in Crohn’s disease, its causal agency has yet to be demonstrated by an adequately powered study. We discuss the strengths and weaknesses of the case being made by epidemiologists, geneticists, clinicians and basic researchers, and consolidate their findings into a model that provides mechanistic plausibility to the claim. Specifically, converging data sets suggest that local activation of vitamin D coordinates the activity of the innate and adaptive arms of immunity, and of the intestinal epithelium, in a manner that promotes barrier integrity, facilitates the clearance of translocated flora and diverts CD4 T cell development away from inflammatory phenotypes. Since smoking is an important risk-altering exposure, we also discuss its newly established melanizing effect, as well as other emerging evidence linking tobacco use to immune function through vitamin D pathways.

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Incidence of inflammatory bowel disease in Corsica from 2002 to 2003

Cited by 21 publications

References 17 publications

Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends

Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends

Current global trends in the incidence of pediatric-onset inflammatory bowel disease

Linking Vitamin D Deficiency to Inflammatory Bowel Disease

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