Incidence of gallstones in a population of patients with cirrhosis

Fornari, Fabio; Imberti, Davide; Squillante, Maria Maddalena; Squassante, Lisa; Civardi, Giuseppe; Buscarini, Elisabetta; Cavanna, Luigi; Caturelli, Eugenio; Buscarini, L

doi:10.1016/s0168-8278(05)80152-7

Cited by 59 publications

(48 citation statements)

References 17 publications

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“…In a study from Dhaka [16], no statistically significant relation between Child-Pugh score and serum creatinine was found but in our study, change of creatinine with Child-Pugh score was statistically significant (p<0.001). Fornari F et al, [17] showed 30% of patients with cirrhosis had gall stones, risk of developing stones most strongly associated with Child's grade C & alcoholic cirrhosis with a yearly incidence of about 5%.In our study cholelithiasis in CLD was incidental USG finding. Majority (8%) occurred in ALD and 4% in HEP-C.…”

Section: Resultssupporting

confidence: 53%

Study on Assessment of Renal Function in Chronic Liver Disease

Das

Bhattacharyya

Paria

et al. 2015

JCDR

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Section: Resultssupporting

confidence: 53%

Study on Assessment of Renal Function in Chronic Liver Disease

Das

Bhattacharyya

Paria

et al. 2015

JCDR

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“…[4][5][6] The reported estimated annual incidence of cholelithiasis in patients with cirrhosis is 2.6% to 5.5%. 4,[7][8][9] The influence of gallstone disease on the survival of patients with liver cirrhosis is controversial 10 ; however, surgical intervention for symptomatic gallstone disease poses a significant risk for morbidity and mortality.…”

confidence: 99%

Endoscopic stenting of the gallbladder for symptomatic gallbladder disease in patients with end-stage liver disease awaiting orthotopic liver transplantation

1999

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Cholecystectomy in patients with advanced cirrhosis is associated with excessive morbidity and mortality. Because open cholecystectomy in patients with Child's class C cirrhosis has a reported mortality rate as high as 83%, symptomatic gallbladder disease in patients awaiting orthotopic liver transplantation (OLT) poses a unique clinical problem. The goal of this study is to determine whether the treatment of symptomatic gallbladder disease with endoscopic stenting of the gallbladder effectively reduces biliary symptoms and complications or the need for cholecystectomy. Thirteen patients with symptomatic gallbladder disease with and without cholelithiasis and advanced cirrhosis who were candidates for OLT underwent placement of a biliary stent from the gallbladder to the duodenum at endoscopic retrograde cholangiography. In each patient, biliary symptoms and complications ceased after stent placement. Seven patients underwent successful OLT 1 to 24 months after the procedure. One patient subsequently became a noncandidate for OLT and died of diabetes complications 3 years after the procedure. Five others are awaiting OLT (6 to 28 months postprocedure). One patient had recurrent pericholecystic fluid collection requiring percutaneous drainage and antibiotic therapy 8 months after the procedure. No patient has had recurrent symptoms, and currently all patients are free of complications. None required surgical intervention of the gallbladder or biliary tree. We conclude that endoscopic stenting of the gallbladder is the preferred treatment for symptomatic gallbladder disease in patients with end-stage liver disease awaiting OLT. This approach is noninvasive, safe, and effective in preventing potential morbidity and mortality.

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“…Patients with cirrhosis of the liver have a higher incidence and prevalence of cholelithiasis compared with the general population (1)(2)(3). Some studies have proposed changes in gallbladder motility as a causative factor in the pathogenesis of cholelithiasis (4).…”

Section: Introductionmentioning

confidence: 99%

Autonomic neuropathy and gallbladder motility in patients with liver cirrhosis

Kul¹,

Serin²,

Yakar³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Impaired gallbladder motility has been suggested as a contributor to increased incidence of gallstones in patients with liver cirrhosis. The purpose of this study was to determine gallbladder function and its relation with autonomic neuropathy in liver cirrhosis. Materials and Methods: Gallbladder function was measured using ultrasonography in 48 patients with liver cirrhosis and in 31 controls. Autonomic neuropathy tests were applied in patients with liver cirrhosis. Patients with liver cirrhosis were analyzed in subgroups according to the severity of disease using the Child-Pugh classification. Results: Fasting gallbladder volume was 16.2 mL (range: 2.1 mL-71.9 mL) in patients and 17.6 mL (range: 4.9 mL-76.6 mL) in controls. There were no differences in fasting gallbladder volume among the study groups (p>0.05). Gallbladder ejection fraction was significantly higher in patients compared with controls (84% vs. 65%) (p<0.001). No correlation was found between gallbladder ejection fraction and autonomic neuropathy (p>0.05). Conclusion: Our results indicate that liver cirrhosis does not impair gallbladder emptying, and that there is no association between gallbladder motility and autonomic neuropathy. Further investigations are required to explain increased gallbladder motility in liver cirrhosis.

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Incidence of gallstones in a population of patients with cirrhosis

Cited by 59 publications

References 17 publications

Study on Assessment of Renal Function in Chronic Liver Disease

Study on Assessment of Renal Function in Chronic Liver Disease

Endoscopic stenting of the gallbladder for symptomatic gallbladder disease in patients with end-stage liver disease awaiting orthotopic liver transplantation

Autonomic neuropathy and gallbladder motility in patients with liver cirrhosis

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