Incidence of fentanyl-induced coughing and effect of injection velocity

Akçaboy, Zeynep Nur; Akcaboy, Y.; Abdullayev, Ruslan; Göğüş, Nermin

doi:10.1097/00003643-201206001-00457

Cited by 1 publication

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Opioid related cough is a common phenomenon during intravenous anesthesia induction. 11 - 13 Cause of opioid induced cough may be sudden adduction in vocal cord muscles caused by opioid induced muscle rigidity, supraglottic obstruction by soft tissues; or histamine release from mast cells in respiratory tract. 7 , 8 Agarwal reported reduced frequency of fentanyl induced cough in patients who use bronchodilator agents.…”

Section: Discussionmentioning

confidence: 99%

“…Frequency of fentanyl induced cough has a wide range and it varies with injection site, velocity, dosage and concentration of fentanyl. 11 , 16 Different studies show 21.3% to 28% cough rates with 2 µg kg -1 fentanyl. 9 , 15 , 17 , 18 Lin et al reported 65% cough rate with 2.5 µg kg -1 fentanyl.…”

Section: Discussionmentioning

confidence: 99%

“…10 Akcaboy et al compared 2 seconds and 20 seconds and reported 11.4% and 8.6% cough frequencies, respectively. 11 Schäpermeier et al compared 2 seconds, 5 seconds and 10 seconds and reported 2%, 3% and 6% cough frequencies, respectively. 21 We standardized the velocity of injection to 3 seconds in our study.…”

Section: Discussionmentioning

confidence: 99%

“…3 , 9 Yakici et al reported injection velocity of fentanyl also effects cough incidence 10 , however Akcaboy et al found no effect of injection velocity on cough incidence. 11 Several methods are tried to prevent fentanyl induced cough. 3 , 4 , 11 - 13 But, in literature there is no data about the effect of pheniramine maleat on fentanyl induced cough.…”

Section: Introductionmentioning

confidence: 99%

“… 11 Several methods are tried to prevent fentanyl induced cough. 3 , 4 , 11 - 13 But, in literature there is no data about the effect of pheniramine maleat on fentanyl induced cough.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough

et al. 2016

View full text Add to dashboard Cite

Objective:Fentanyl is frequently used during anesthesia induction. The use of fentanyl can cause cough through different mechanisms. Here, we aimed to investigate effects of pheniramine maleate (PM), an antihistaminic agent, and compare it with lidocaine on fentanyl induced cough.Methods:This is a randomized double-blind prospective clinical study of ASA I-II, 120 patients scheduled for elective abdominal surgery. Patients were administered drugs intravenously and randomly allocated into three groups: Group C (2 ml 0.9 % normal saline), Group L (1mg/kg lidocaine), and Group F (PM 45.5 mg). 90 seconds after administration, 2µ/kg fentanyl was applied in three seconds to all patients. Severity of cough (mild: 1-2, moderate: 3-5, severe> 5), time of the cough and vital parameters were recorded 90 seconds after fentanyl injection.Results:Eight patients (25%) in Group C had fentanyl induced cough whereas three patients (7.5%) in Group L and one patient (2.5%) in Group F experienced this phenomenon. There was statistically significant difference between Group F and Group C (p<0.05); however, differences between Group L and Group C or Group F and Group L were not statistically significant (p>0.05).Conclusions:Pheniramine Maleate 45.5 mg is better that placebo and as effective as lidocaine to prevent fentanyl induced cough.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 11 Several methods are tried to prevent fentanyl induced cough. 3 , 4 , 11 - 13 But, in literature there is no data about the effect of pheniramine maleat on fentanyl induced cough.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations