Incidence of fast bone losers and factors affecting changes in bone mineral density: A cohort study in a rural Japanese community

Yoshimura, Nagahisa

doi:10.1007/bf02239486

Cited by 12 publications

(16 citation statements)

References 25 publications

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“…A detailed profile of the Miyama cohort is available elsewhere [11][12][13], and is here summarized briefly, as follows. A list of all inhabitants born in this village between 1910 and 1949, and therefore aged 40-79 years, was compiled from the register of residents as at the end of 1989.…”

Section: Participants and Methodsmentioning

confidence: 99%

“…It was begun in 1990 among men and women resident in a mountain area, Miyama village, in the same region [11][12][13]. In this case our aim was to ascertain rates of bone loss of the lumbar spine and proximal femur over 10 years in men and women, and to clarify the secular trend as regards bone loss at these sites so as to permit prediction of the future incidence of osteoporosis in Japan.…”

Section: Introductionmentioning

confidence: 99%

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Bone Loss at the Lumbar Spine and the Proximal Femur in a Rural Japanese Community, 1990-2000: The Miyama Study

Yoshimura

Kinoshita

Danjoh³

et al. 2002

Osteoporosis International

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Bone mineral density (BMD) was measured over a ten year period in a cohort study in Miyama village, Wakayama Prefecture, Japan, to provide information on rate of bone loss in the mature and elderly population. Four hundred subjects were selected by sex and age decade from the full list of residents born in 1910-1949, and aged 40-79 years at the end of 1989, with 50 men and 50 women in each age decade. Baseline BMD of the lumbar spine and the proximal femur was measured using dual energy X-ray absorptiometry (DXA) in 1990 and again in 1993, 1997 and 2000. Annual rate of change in BMD (% per year) in the lumbar spine in men in their forties, fifties, sixties and seventies was 0.17, 0.55, 0.01 and -0.16, respectively, and in women, -0.87, -0.83, -0.48 and -0.48, respectively. Thus in men, BMD at the lumbar spine increased in all age strata but the oldest, when it decreased, whereas in women, it decreased in all age strata. On the other hand, BMD at the proximal femur decreased in both sexes in all age strata. Our results show that bone loss rates differ depending on the site involved, demonstrating that different strategies are needed for the prevention of bone loss in the spine and hip.Furthermore, we found evidence of differences in BMD for given age strata between birth cohorts. Data in 1990 and in 2000 showed significant improvements for men in their sixties and for women in their fifties, suggesting that future problems of osteoporosis might be less severe than has previously been predicted in Japan.

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Section: Participants and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bone Loss at the Lumbar Spine and the Proximal Femur in a Rural Japanese Community, 1990-2000: The Miyama Study

Yoshimura

Kinoshita

Danjoh³

et al. 2002

Osteoporosis International

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“…The following items were significantly related to annual changes in BMD: medication with tranquillizers in both sexes, milk consumption in males, body weight and height at the initial measurement, and T. Hashimoto et al small fish consumption in females. Partial regression coefficients for menopause and the postmenopausal period were also significant in females [7].…”

Section: Risk Factors For Bone Lass Suggested By the Cohort Studymentioning

confidence: 88%

“…Among 400 participants in the initial examination in each cohort, 355 (170 males and 185 females) in Miyama village and 369 (181 males and 188 females) in Taiji town were eligible for investigation of annual changes in BMD. The incidence of fast bone losers was 2.4% in men and 9.7% in women in Miyama village [7]; in Taiji town it was 2.2% in men and 6.9% in women. The incidence of fast bone losers in each cohort are shown by sex and age in Table 1.…”

Section: The Incidence 0/ Fast Bone Losersmentioning

confidence: 99%

“…Also, to deterrnine the distribution of BMD and the incidence of fast bone losers of lumbar BMD by sex and age, and factors affecting changes in BMD in residents in two areas of Wakayama prefecture, Japan, we carried our population surveys [4][5][6][7][8][9]. In Miyama village, located in a mountainous area, a cohort of 1543 inhabitants aged 40-79 years (716 males and 827 females) was established from a register of inhabitants [6].…”

Section: Vertebral Fracture and Bone Mineral Densitymentioning

confidence: 99%

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Epidemiology of osteoporosis in Japan

1997

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Association between height loss and bone loss, cumulative incidence of vertebral fractures and future quality of life: the Miyama study

et al. 2007

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Among 299 of 400 participants, changes in height over 10 years for men in their 40s, 50s, 60s and 70s were -0.7 cm, -0.5 cm, -1.2 cm and -1.5 cm, respectively, compared with -0.7 cm, -1.4 cm, -2.1 cm and -3.7 cm in women, respectively. No significant relationships between change in height and rate of change in BMD at the lumbar spine and femoral neck after adjustment for age in men (lumbar spine, beta = 0.058, standard error of the mean (SE) = 0.031, P = 0.501, R(2) = 0.038; femoral neck, beta = 0.100, SE = 0.038, P = 0.228, R(2) = 0.121) were identified. By contrast, among women, a significant positive association was identified between height change and change rate of BMD at the lumbar spine after adjusting for age (beta = 0.221, SE = 0.039, P = 0.012, R(2) = 0.069), while no significant relationship was found between height change and change rate at the femoral neck (beta = 0.107, SE = 0.039, P = 0.229, R(2) = 0.048). No significant relationship was noted between vertebral fractures (VFx) and height at baseline in men and women (men: odds ratio (OR) 0.93, 95% confidence interval (CI) 0.81-1.05, P = 0.24; women: OR 0.97, 95% CI 0.87-1.08, P = 0.58) or between VFx and height loss (men: OR 1.31, 95% CI 1.00-1.71, P = 0.051; women: OR 1.20, 95% CI 0.94-1.53, P = 0.14). In both men and women, no significant relationship was identified between utility of the EuroQol EQ5D questionnaire and height at baseline (men: beta = -0.148, SE = 0.003, P = 0.202, R(2) = 0.076; women: beta = 0.127, SE = 0.004, P = 0.235, R(2) = 0.048), and height change (men: beta = -0.078, SE = 0.008, P = 0.452, R(2) = 0.065; women: beta = 0.053, SE = 0.010, P = 0.608, R(2) = 0.038).

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Incidence of fast bone losers and factors affecting changes in bone mineral density: A cohort study in a rural Japanese community

Cited by 12 publications

References 25 publications

Bone Loss at the Lumbar Spine and the Proximal Femur in a Rural Japanese Community, 1990-2000: The Miyama Study

Bone Loss at the Lumbar Spine and the Proximal Femur in a Rural Japanese Community, 1990-2000: The Miyama Study

Epidemiology of osteoporosis in Japan

Association between height loss and bone loss, cumulative incidence of vertebral fractures and future quality of life: the Miyama study

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