Association between height loss and bone loss, cumulative incidence of vertebral fractures and future quality of life: the Miyama study

Abstract

Among 299 of 400 participants, changes in height over 10 years for men in their 40s, 50s, 60s and 70s were -0.7 cm, -0.5 cm, -1.2 cm and -1.5 cm, respectively, compared with -0.7 cm, -1.4 cm, -2.1 cm and -3.7 cm in women, respectively. No significant relationships between change in height and rate of change in BMD at the lumbar spine and femoral neck after adjustment for age in men (lumbar spine, beta = 0.058, standard error of the mean (SE) = 0.031, P = 0.501, R(2) = 0.038; femoral neck, beta = 0.100, SE = 0.038, P = 0.228, R(2) = 0.121) were identified. By contrast, among women, a significant positive association was identified between height change and change rate of BMD at the lumbar spine after adjusting for age (beta = 0.221, SE = 0.039, P = 0.012, R(2) = 0.069), while no significant relationship was found between height change and change rate at the femoral neck (beta = 0.107, SE = 0.039, P = 0.229, R(2) = 0.048). No significant relationship was noted between vertebral fractures (VFx) and height at baseline in men and women (men: odds ratio (OR) 0.93, 95% confidence interval (CI) 0.81-1.05, P = 0.24; women: OR 0.97, 95% CI 0.87-1.08, P = 0.58) or between VFx and height loss (men: OR 1.31, 95% CI 1.00-1.71, P = 0.051; women: OR 1.20, 95% CI 0.94-1.53, P = 0.14). In both men and women, no significant relationship was identified between utility of the EuroQol EQ5D questionnaire and height at baseline (men: beta = -0.148, SE = 0.003, P = 0.202, R(2) = 0.076; women: beta = 0.127, SE = 0.004, P = 0.235, R(2) = 0.048), and height change (men: beta = -0.078, SE = 0.008, P = 0.452, R(2) = 0.065; women: beta = 0.053, SE = 0.010, P = 0.608, R(2) = 0.038).

Usefulness of Estimated Height Loss for Detection of Osteoporosis in Women

“…This concurs with the suggestion backed up by previous research (Milliken et al, 2009;Versluis et al, 1999;Yoshimura et al, 2008) that there is no equilibrium of bone remodeling with age. In women in particular, this can be explained by estrogen deficiency due to the decreased ovarian function associated with menopause, which has the effect of markedly increasing the rate of bone loss, followed by a subsequent age-related gradual reduction in osteogenic function, leading to the continuation of that bone loss.…”

“…Yoshimura et al (2008) reported that 299 of 400 patients experienced a reduction in height. According to a study conducted on 1,270 middle-aged Norwegian people and 494 Dutch women, the magnitude of height loss also increased in an age-dependent manner (Joakimsen et al, 1998;Versluis et al, 1999).…”

“…Thus, one of the potential factors used to determine the overall risks of developing an osteoporotic state is the height loss that occurs with physical aging; this is also a marker of the outcome of bone deformities, which are hallmarks of osteoporosis (Adachi et al, 2001;Yoshimura et al, 2008). In particular, the osteoporotic deformity of the spine may deform the thoracic vertebrae, impair respiratory functions and, ultimately, lower the quality of life (Schlaich et al, 1998).…”

Efficacy and safety of the target puncture technique for treatment of osteoporotic vertebral compression fractures with intravertebral clefts

“…The most frequent leakage type was intradiscal leakage in all three groups, with no significant difference in the types of cement leakage. Yoshimura et al 27 reported that the cumulative incidence of new adjacent fracture ranged from 5.1% to 22.2% at >10 years follow-up. Trout et al 28 also stated a similar incidence (19.9%), and our result was similar to their results (16/104 patients).…”

Validity of knee-estimated height to assess standing height in older adults: A secondary longitudinal analysis of the Mexican health and aging study

“…More recently it has come to the attention of researchers and clinicians the fact that height loss could have an important clinical relevance and that it may predict adverse outcomes (9, 10, 3, 11). Moreover, having an accurate approximation of SH is important when estimating BMI and other body composition parameters (e.g.…”