Incidence of endometrial hyperplasia

Reed, Susan D.; Newton, Katherine M.; Clinton, Walter L.; Epplein, Meira; Garcia, Rochelle L.; Allison, Kimberly H.; Voigt, Lynda F.; Weiss, Noel S.

doi:10.1016/j.ajog.2009.02.032

Cited by 160 publications

(123 citation statements)

References 25 publications

(22 reference statements)

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“…Other authors have reported slightly higher incidence. The incidence of endometrial hyperplasia in present study and studies by Allison et al and Reed et al [18] was highest among women aged 45-55 years. The comparative studies show that there was decrease in the incidence of endometrial hyperplasia with advancing age.…”

Section: Discussionsupporting

confidence: 67%

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Significance of Clinical and Histopathological Evaluation in Wom en With Postmenopausal Bleeding: A Hospital Based Study in Kashmir

Kant¹,

Iqbal²,

Rather³

et al. 2015

jemds

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BACKGROUND:Postmenopausal bleeding is a dreaded symptom both for the women and gynaecologist. Though it can be of benign origin, malignancy has to be ruled out and as such needs prompt evaluation. OBJECTIVE: (1) To study the etiological factors of postmenopausal bleeding and establish various endometrial causes of postmenopausal bleeding through histopathological evaluation. (2) To investigate the clinical significance of postmenopausal bleeding in terms of risk factors, incidence of malignancy and histopathological evaluation. METHODOLOGY: This observational study was conducted at Lalla Ded Hospital Srinagar over a period of 18 months in which 116 cases of postmenopausal bleeding were enrolled in the study. All patients were subjected to detailed history, examination and investigations followed by diagnostic curettage. Endometrial curretings were sent for histopathological examination. STATISTICAL ANALYSIS: Statistical Package for Social Sciences (SPSS V.16.0) and Microsoft Excel were used to carry statistical analysis of data. Data was analyzed with the help of descriptive statistics viz. %age, mean S.D. Graphically data was presented by bar and pie diagrams. RESULTS: Majority of the patients with postmenopausal bleeding were in the age of 45-55 years (63.8%), majority of cases 64(55.2%) were para 1-3, uterus was of normal size in 53 cases (45.7%). Mean age of onset of menopause was 48.7 years. Obesity was found in 40 cases (34.5%), hypertension in 35 cases (30.2%), and diabetes in 12 cases (10.3%). Out of the 116 cases studied; the most common cause of bleeding in the postmenopausal age group was endometrial hyperplasia in 41 out of 116(35.3%) followed by atrophic endometrium in 39 of 116(33.6%). Endometrial polyps were found in 9 (7.8%) cases, proliferative endometrium was found in 10(8.6%), endometritis was seen in 3(2.6%) cases, secretory endometrium in 1(0.9%) cases and adenofibroma in 1(0.9%) cases. The incidence of endometrial carcinoma in this study was 6% (7 out of 116 cases) mean age being 56.7 years and with duration of menopause more than 3 years. In 5 cases (4.3%) no endometrial tissue was obtained, hence no diagnosis could be made.

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Section: Discussionsupporting

confidence: 67%

“…Simple hyperplasia was the commonest finding among the types of hyperplasias in postmenopausal bleeding in the present study and study by Allison et al whereas Gredmark et al [14] and Reed et al [18] have noted complex hyperplasia as more common entity in postmenopausal age.…”

Section: Discussionsupporting

confidence: 62%

Significance of Clinical and Histopathological Evaluation in Wom en With Postmenopausal Bleeding: A Hospital Based Study in Kashmir

Kant¹,

Iqbal²,

Rather³

et al. 2015

jemds

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“…Although its etiology has not been fully clarified, it is implicated that the most cases of EH result from high levels of estrogen, combined with insufficient levels of progesterone (13,14). In postmenopausal women, it frequently manifests itself with abnormal uterine bleeding (13). It was diagnosed with histopathological examination of biopsy, curettage or hysterectomy material (15).…”

Section: Discussionmentioning

confidence: 99%

Histopathological findings in women that living Elazig with abnormal uterine bleeding: in 20 years

Solmaz¹

2017

J Turgut Ozal Med Cent

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Aim: Abnormal uterine bleeding refers to any uterine bleeding that occurs in excessive amounts of regular menstrual bleeding or any postmenopausal bleeding. The present study aims to determine histopathological findings in Turkish women with abnormal uterine bleeding in Elazığ. Material and Methods: Retrospectively 420 women with abnormal uterine bleeding were included in the study. Hematoxylin and eosin sections of the cases were re-evaluated by a single pathologist. Results: Of the 316 premenouposal cases %37,02 was diagnosed as (n=117) proliferative endometrium, %22,46 as (n=71) secretuar endometrium, as %3,79 (n=12) desidualisation, as %1,26 (n=4) atrophy, as %2,53 (n=8) placental tissue, as %12 (n=38) dysfunctional uterine bleeding, %12,34 (n=39) as endometrial polyp, %7,9 (n=25) as endometrial hyperplasia, and %0,63 (n=2) as endometrial adenocarcinoma. Of the 104 postmenouposal cases diagnosed as %10,57 (n=11) proliferative endometrium, %0,96 as (n=1) secretuar endometrium, %17,30 (n=18) as desidualisation, %13,46 (n=14) as endometrial polyp, %39,42 (n=41) atrophy, %12,5 (n=13) as endometrial hyperplasia, %5,76 (n=6) as endometrial adenocarcinoma. Conclusions: In our region, because endometrial sampling results belong patients with abnormal uterine bleeding which is usually concordant to age and menstrual cycle, We conclude that non-invasive methods should be tried before sampling. Endometrial carcinoma risk is consistent with the literature,so endometrial samplings should not be avoided?

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“…These are polycystic ovary syndrome (chronic anovulation), nulliparity, early menarche, delayed menopause (>55), unmet (without progesterone) estrogen replacement therapy (ERT), obesity, tamoxifen use, and estrogen secreting ovarian tumors (10,11). Endometrial pathologies are frequently seen in perimenopausal women (50-54 years) with early symptoms, but rarely seen under age 30 (12). They are commonly diagnosed with endometrial biopsy, curettage, or post-hysterectomy (13).…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Accuracy of Endometrial Sampling in Endometrial Hyperplasia

Başaranoğlu¹,

Ağaçayak

Hatırnaz³

et al. 2017

Gynecol Obstet Reprod Med

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OBJECTIVE: Endometrial hyperplasia is a premalignant lesion characterized with hyperplastic changes in endometrial gland and stromal structures. Its incidence is not exactly known. This study evaluated the accuracy of endometrial sampling of the patients whose pathological results were endometrial hyperplasia and had undergone hysterectomy (paraffin sections). STUDY DESIGN:Patients that diagnosed with endometrial hyperplasia by endometrial biopsy and/or hysterectomy at Dicle University School of Medicine Department of Obstetrics and Gynecology between January 2006 and July 2014 were retrospectively evaluated. Sensitivity, specificity, and positive and negative predictive values of endometrial biopsy to predict postoperative hysterectomy result were calculated. Discrete results in endometrial sampling and hysterectomy were recorded separately. Statistical analyses were conducted with corresponding appropriate methods. RESULTS:Mean ages of pre and postmenopausal patients were 42.6±4.8 (28-50) and 57.7±7.7 (50-79) years, respectively. For the efficiency of endometrial sampling to predict definite pathologic diagnosis, sensitivity was 71.9%, specificity was 87.5%, positive predictive value was 79.3%, and negative predictive value was 82.3%. When the accuracy of endometrial sampling with the pathologic diagnosis was evaluated, 38 patients had accurate (47.5%), and 42 patients had discrete (52.5%) results. CONCLUSION:The presence of atypia determines the treatment in patients with endometrial hyperplasia. Hysterectomy should not be the first option in endometrial hyperplasia patients without atypia, and medical treatment and curettage options should be considered. Experienced staff should perform and evaluate endometrial samplings. We consider that this will increase the success in diagnosis, and could change treatment options.

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Incidence of endometrial hyperplasia

Cited by 160 publications

References 25 publications

Significance of Clinical and Histopathological Evaluation in Wom en With Postmenopausal Bleeding: A Hospital Based Study in Kashmir

Significance of Clinical and Histopathological Evaluation in Wom en With Postmenopausal Bleeding: A Hospital Based Study in Kashmir

Histopathological findings in women that living Elazig with abnormal uterine bleeding: in 20 years

The Diagnostic Accuracy of Endometrial Sampling in Endometrial Hyperplasia

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