Incidence of diarrhea and associated risk factors in patients with traumatic brain injury and enteral nutrition

Vieira, Luiza Valois; Pedrosa, Livia Alves Carvalho; Souza, Viviane Sahade; Paula, Cristiane Assis; Rocha, Raquel

doi:10.1007/s11011-018-0287-2

Cited by 29 publications

(22 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical manifestations are usually gastric retention, abdominal distension and high intra-abdominal pressure [13] . However, it is hard to provide an objective evaluation of gastrointestinal dysfunction in clinical practice because there is still a lack of quantitative standards to classify severity although there are numerous relevant research reports and many scholars have de ned gastrointestinal dysfunction and continuously improved and uni ed the de nition [14][15] . GIF scores provide a quanti cation evaluation for the varying degrees of gastrointestinal dysfunction and objectively and accurately re ect gastrointestinal functional status.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Failure Score in Children with Traumatic Brain Injury

Zhou

Lü

Tang

2020

Preprint

View full text Add to dashboard Cite

PurposesTo review the value of the gastrointestinal failure (GIF) score in children with different degrees of traumatic brain injury (TBI) by analyzing the correlation between outcome and gastrointestinal function.MethodsA total of 165 children with TBI who were diagnosed and treated in the surgical intensive care unit (SICU) for longer than 72 h between August 2017 and 2019 were retrospectively analyzed. Admission parameters were sex, age, Glasgow Coma Scale (GCS) score, body mass index (BMI), leukocyte count, C-reactive protein (CRP), hemoglobin (Hb) and hematocrit (Hct), blood glucose, lactic acid, procalcitonin (PCT), albumin, plasma osmotic pressure, prothrombin time (PT) and activated partial thromboplastin time (APTT). In order to predict outcome, Sequential Organ Failure Assessment (SOFA) score, Pediatric Clinical Illness Score (PCIS) and mean GIF score for the first three days were also combined.ResultsThe percent of patients with gastrointestinal dysfunction on the first day was 78.8%. Food intolerance (FI) developed in 36.4% and intra-abdominal hypertension (IAH) in 21.8% of patients. The GIF score and mean GIF score for the first three days in children with different degrees of TBI were significantly different (P<0.05); they were also significantly different between those who died and those who survived (P<0.05). The mean GIF score for the first three days was identified as an independent risk factor for mortality (odds ratio>1, 95% confidence interval=1.457 to 16.016, P<0.01), as was the PCIS. Receiver operating characteristic (ROC) curve analysis suggested that the mean GIF score for the first three days had the same calibrating power as the PCIS in discriminating the risk of death of children.ConclusionThe incidence of gastrointestinal dysfunction in children with TBI is high. The GIF score has its ability to judge gastrointestinal system. The mean GIF score for the first three days has high prognostic value for ICU mortality in the SICU.

show abstract

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Failure Score in Children with Traumatic Brain Injury

Zhou

Lü

Tang

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Children in ICUs with gastrointestinal bleeding, dysfunction or failure often endure prolonged hospital stays and have increased mortality [4]. However, objectively evaluating gastrointestinal dysfunction is difficult because quantitative standards to classify severity are lacking [5,6]. Few of the various existing scoring systems for determining the severity of disease in pediatric patients include an evaluation of gastrointestinal function [7].…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal failure score in children with traumatic brain injury

Zhou

Tang

2021

BMC Pediatr

View full text Add to dashboard Cite

Background To review the value of the gastrointestinal failure (GIF) score in children with different degrees of traumatic brain injury (TBI) by analyzing the correlation between outcome and gastrointestinal function. Methods A total of 165 children with TBI who were diagnosed and treated in the surgical intensive care unit (SICU) for longer than 72 h between August 2017 and September 2019 were analyzed. Admission parameters included sex, age, Glasgow Coma Scale (GCS) score, body mass index (BMI), leukocyte count, C-reactive protein (CRP), hemoglobin (Hb), hematocrit (Hct), blood glucose, lactic acid, procalcitonin (PCT), albumin, plasma osmotic pressure, prothrombin time (PT) and activated partial thromboplastin time (APTT). To predict outcomes, the Pediatric Sequential Organ Failure Assessment (SOFA) score, Pediatric Clinical Illness Score (PCIS), and mean GIF score for the first three days were combined. Results The percentage of patients with gastrointestinal dysfunction on the first day was 78.8 %. Food intolerance (FI) and intra-abdominal hypertension (IAH) developed in 36.4 and 21.8 % of the patients, respectively. The GIF score and mean GIF score for the first three days were significantly different between children with different degrees of TBI (P < 0.05); these scores were also significantly different between patients who died and those who survived (P < 0.05). The mean GIF score for the first three days was identified as an independent risk factor for mortality (odds ratio > 1, 95 % confidence interval = 1.457 to 16.016, P < 0.01), as was the PCIS. Receiver operating characteristic (ROC) curve analysis suggested that the mean GIF score for the first three days had the same calibrating power as the PCIS in discriminating the risk of death of children. Conclusions The incidence of gastrointestinal dysfunction in children with TBI is high. The GIF score has the ability to reflect the status of the gastrointestinal system. The mean GIF score for the first three days has high prognostic value for ICU mortality in the SICU.

show abstract

“…Several studies have shown an association between diarrhea and mortality [6][7][8][9][10][11][12][13][14], and this association remained even in ICU patients without CDI [8]. Taito et al conducted a systematic review and demonstrated that diarrhea was associated with the length of hospital stay and ICU mortality [14]; however, all previous studies de ned diarrhea based on dichotomized criteria with respect to consistency and frequency.…”

Section: Introductionmentioning

confidence: 99%

Association between diarrhea quantity and in-hospital mortality in intensive care unit patients: A retrospective cohort study

Yamamoto

Yamazaki

Yamamoto

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Previous studies have shown that diarrhea is associated with increased mortality of patients in intensive care units (ICUs). However, these studies used dichotomized cutoff values, even if diarrhea was a continuous condition. This study aimed to assess the association between diarrhea quantity and mortality in ICU patients with newly developed diarrhea. Methods We conducted this single-center retrospective cohort study at the Kameda Medical Center ICU. We consecutively included all adult ICU patients with newly developed diarrhea in the ICU between January 2017 and December 2018. Newly developed diarrhea was defined based on a Bristol stool chart scale ≥ 6 and frequency of diarrhea ≥ 3 times per day. We excluded patients who already had diarrhea on the day of ICU admission among other criteria. We collected data on the quantity of diarrhea on the day when patients newly developed diarrhea. The primary outcome was in-hospital mortality. The risk ratio (RR) and 95% confidence interval (CI) for the association between the quantity of diarrhea and mortality were estimated using multivariable-modified Poisson regression models adjusted for the Charlson Comorbidity Index, sequential organ failure assessment score, and serum albumin levels. Results Among 231 participants, 68.4% (158/231) were men; the median age of the patients was 72 years. The median quantity of diarrhea was 401 g (interquartile range [IQR] 230‒645 g), and in-hospital mortality was 22.9% (53/231). More diarrhea at baseline was associated with higher in-hospital mortality; the unadjusted RR (95% CI) per 200-g increase was 1.10 (1.01‒1.19). This association remained in the multivariable-adjusted analysis; the adjusted RR (95% CI) per 200-g increase was 1.10 (1.01‒1.20). Conclusions A greater quantity of diarrhea was an independent risk factor for in-hospital mortality. The quantity of diarrhea may be an indicator of disease severity in ICU patients.

show abstract

Incidence of diarrhea and associated risk factors in patients with traumatic brain injury and enteral nutrition

Cited by 29 publications

References 23 publications

Gastrointestinal Failure Score in Children with Traumatic Brain Injury

Gastrointestinal Failure Score in Children with Traumatic Brain Injury

Gastrointestinal failure score in children with traumatic brain injury

Association between diarrhea quantity and in-hospital mortality in intensive care unit patients: A retrospective cohort study

Contact Info

Product

Resources

About