Incidence of congenital rubella syndrome in 19 regions of Europe in 1980–1986

Mata, Isabel de la; Wals, Philippe De; Dolk, Helen; Lechat, M. F.; Beckers, R; Borlee, I.; Lys, F.; Zori, Roberto T.; Goujard, J; Stoll, Claude; Aymé, Ségolène; Hansen-Koenig, Danielle; Karkut, G; Galanti, Claudio; Marchi, Massimiliano; Bianchi, Fabio José; Calabrò, Anna Rita; Lungarotti, S.; Calzolari, Elisa; Radić, A; Lillis, F.; Stone, Deborah M.; Harris, F.; Nevin, N. C.; Kate, L. Ten; Svel, I; Ligutić, Ivo; Cuschieri, Alfred

doi:10.1007/bf00145055

Cited by 6 publications

(2 citation statements)

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“…We found 66 study populations that met the eligibility criteria for demonstrating the frequency of manifestations of CRS . One article reported on two distinct cohorts examined at different ages using different methods, which we treated as two separate study populations .…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of the Manifestations of Congenital Rubella Syndrome in Infants and Characterization of Disability‐Adjusted Life Years (DALYs)

et al. 2014

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Congenital rubella syndrome (CRS) continues to cause disability among unvaccinated populations in countries with no or insufficient rubella vaccine coverage to prevent transmission. We systematically reviewed the literature on birth outcomes associated with CRS to estimate the duration, severity, and frequency of combinations of morbidities. We searched PubMed, the Science Citation Index, and references from relevant articles for studies in English with primary data on the frequency of CRS manifestations for ≥20 cases and identified 65 studies representing 66 study populations that met our inclusion criteria. We abstracted available data on CRS cases with one or more hearing, heart, and/or eye defect following maternal rubella infection during the period of 0-20 weeks since the last menstrual period. We assessed the quality and weight of the available evidence using a modified Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Most of the evidence originates from studies in developed countries of cohorts of infants identified with CRS in the 1960s and 1970s, prior to the development of standardized definitions for CRS and widespread use of vaccine. We developed estimates of undiscounted disability-adjusted life years (DALYs) lost per CRS case for countries of different income levels. The estimates ranged from approximately 19 to 39 for high-income countries assuming optimal treatment and from approximately 29 to 39 DALYs lost per CRS case in low- and lower- middle-income countries assuming minimal treatment, with the lower bound based on 2010 general global burden of disease disability weights and the upper bound based on 1990 age-specific and treatment-specific global burden of disease disability weights. Policymakers and analysts should appreciate the significant burden of disability caused by CRS as they evaluate opportunities to manage rubella.

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Section: Resultsmentioning

confidence: 99%

Systematic Review of the Manifestations of Congenital Rubella Syndrome in Infants and Characterization of Disability‐Adjusted Life Years (DALYs)

et al. 2014

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“…In Europe, the incidence rate of congenital rubella syndrome decreased during 1980-86 either because of vaccination campaigns in different countries or Corresponding author. because of the practice of immunity screening in women during pregnancy (5).…”

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confidence: 99%