Seroprevalence to some torch agents in a sicilian female population of fertile age

Condorelli, Francesca; Scalia, Guido; Stivala, Aldo; Costanzo, Mario; Adragna, A. D.; Franceschino, C.; Santagati, Maria G.; Furneri, Pio Maria; Marino, Anna Maria Fausta; Castro, A.

doi:10.1007/bf00146274

Cited by 14 publications

(10 citation statements)

References 7 publications

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“…In this study, the prevalence of anti-T. gondii antibodies in women of childbearing age from both the Tuscany and Apulia regions is consistent with the declining trend observed in recent decades in other regions in Italy [18,20], as well as in other European countries [2,9,13] and the United States [14]. In Italy, T. gondii prevalence in women of childbearing age was 41.1% in the late 1980's [6], and a trend toward a decrease has become evident since 2001 [20]. This decline in prevalence is correlated to declining incidence, due to lower exposure to the parasite by changes in nutritional habits and by improved hygiene practices in meat production [19].…”

Section: Discussionsupporting

confidence: 88%

“…Consequently, no accurate estimates of the impact of toxoplasmosis on the population are available, and epidemiological information on the prevalence of T. gondii infection is incomplete, area-based, and mostly focused on pregnant women [3-5, 7, 8, 23, 24, 26, 28, 30]. Epidemiological data on T. gondii seroprevalence in women of childbearing age are even more scant [6,11,18,20].…”

Section: Introductionmentioning

confidence: 99%

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Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

et al. 2020

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Toxoplasmosis is a worldwide health problem. Infection in pregnant women can result in severe fetal morbidity or in subclinical neonatal infection; most subclinical cases develop ocular and neurological sequelae. The purpose of this serological study was to assess the prevalence of Toxoplasma gondii in two populations of women of childbearing age in Siena (Tuscany, Central Italy) and Bari (Apulia, Southern Italy) between 2013 and 2017 and in a group of pregnant women in Bari in 2016–2017. Serum samples were tested for the presence of specific anti-Toxoplasma gondii IgG antibodies by a commercially available ELISA test. The percentage of seropositive subjects in Bari was significantly higher than in Siena (22.4% vs. 12.4%) and an age-related trend was observed. A low prevalence of T. gondii infection (13.8%) was observed among the pregnant women tested. In addition to showing a significant difference between Central and Southern Italy, this study provides updated data on T. gondii seroprevalence in women during childbearing age and pregnancy. The results confirm a trend toward a decrease, especially in younger people and pregnant women.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

et al. 2020

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“…However, our data show a lower seropositivity in women of this age group (19.4%) compared with previous studies in other regions of Italy (in the northern, central, and southern Italy) where values higher than 40% were found [25,28,29]. Actually, the Parma area [25] reflects a situation quite similar to ours, both geographically and for socio-economic factors, including food habits.…”

Section: Discussionsupporting

confidence: 50%

Seroprevalence for toxoplasmosis in individuals living in North West Tuscany: access to Toxo-test in central Italy

Pinto

Castagna

Mattei³

et al. 2011

Eur J Clin Microbiol Infect Dis

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This survey aimed to estimate the prevalence of anti-Toxoplasma IgG and IgM antibodies in people living in north west Tuscany (central Italy) and to investigate the adherence to antenatal screening programs and access to the Toxo-test as well. Sera from a large sample of individuals suspected to have acute infection or from pregnant women (10,352 subjects) aged between 1 day and over 70 years were analysed for both IgG and IgM anti-Toxoplasma antibodies using an immunoenzymatic method or a chemo-luminescent immunoassay. Overall, the seroprevalence of IgG antibodies was 21.4% (95% CI 20.62-22.20). A positive trend according to age was found, with low positivity observed in younger age groups. Among women of reproductive age the prevalence of IgG antibodies was 19.4% (95% CI 18.64-20.26). The overall IgM seroprevalence was 1.07% (95% CI 0.87-1.27). A low IgM prevalence was also observed in women of reproductive age (0.8%; 95% CI 0.65-1.03). Our study seems to indicate that primary prevention is widespread among women. However, an epidemiological surveillance system for toxoplasmosis should be implemented, to assess the risk of congenital toxoplasmosis and to determine the true burden of disease in adults.

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“…Anti-CMV IgG seropositivity ranges between 58.7% and 99.5%. 9,11,12,28,31 In studies performed in different regions of our country, however, anti-CMV IgG seropositivity was observed at similar levels, ranging between 98% and 99%. [16][17][18][19]25 No sign of congenital abnormalities was found the amniocentesis group or in the follow-up group in the perinatal period and in postpartum controls.…”

Section: Discussionmentioning

confidence: 85%

“…[16][17][18][19]25 No sign of congenital abnormalities was found the amniocentesis group or in the follow-up group in the perinatal period and in postpartum controls. In the literature comparison of the other studies around the world, Abdel-Fattah et al 5 from the UK, Condorelli et al, 31 Paradhan et al 9 from Nepal and Vilibic-Cavlek et al 11 from Croatia showed that anti-CMV IgG seropositivity in Turkey was rather higher. Although these results showed that screening of anti-CMV antibodies in Turkish women of reproductive age and potential is necessary, the issue of giving priority to providing information about the routes of transmission and protection from CMV infection and symptoms of the acute infection in Turkey during pregnancy instead of screening remains controversial.…”

Section: Discussionmentioning

confidence: 92%

Impact of Syrian refugees on congenital TORCH infections screening in Turkey

Çoşkun

Gülümser²,

Çoşkun

et al. 2020

J of Obstet and Gynaecol

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Aim: To demonstrate the effect of the Syrian refugee population on the prevalence of congenital TORCH (Toxoplasmosis, Other [syphilis, parvovirus B19], Rubella, Cytomegalovirus [CMV] and Herpes) infections and to evaluate the cost-effectiveness of population-based TORCH screening during pregnancy in Turkey. Methods: Pregnant women (n = 9754) were enrolled. Ultrasonographic findings, immunoglobulin (Ig)M and IgG seropositivity, avidity, amniocentesis and DNA-polymerase chain reaction (PCR) results were compared. Costs were calculated based on invoice amounts from the Health Applications Communique pricing system. Results: The prevalence of TORCH seropositivity in Turkey was not significantly different between all regions (P > 0.05). Overall, 1333 (13.67%) pregnant Syrian refugees were included in the study. Acute CMV, rubella and Toxoplasma gondii infections (according to low IgG avidity in IgM positive patients) were detected in 17.82%, 21.53% and 14.07% of women, respectively. Twenty-four women underwent an amniocentesis procedure and nine of them had positive DNA-PCR and reverse transcription-PCR results. All women with positive results opted to terminate the pregnancy. There was no statistical difference among groups according to the rate of low IgG avidity in IgM-positive patients and termination rates for T. gondii, rubella and CMV (P > 0.05). Total cost for screening the entire study population was presented in US dollars (USD). A total of 71 529 and prenatal diagnosis with positive invasive test results were obtained in nine women: toxoplasmosis in four, CMV in three and rubella in two women. Conclusion: Population-based screening for prenatal TORCH infections is not cost-effective in Turkey. Syrian refugees have a limited effect on the increasing prevalence of congenital TORCH infections.

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Seroprevalence to some torch agents in a sicilian female population of fertile age

Cited by 14 publications

References 7 publications

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

Seroprevalence for toxoplasmosis in individuals living in North West Tuscany: access to Toxo-test in central Italy

Impact of Syrian refugees on congenital TORCH infections screening in Turkey

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