Incidence of Coeliac Disease in the West of Ireland

Mylotte, M. J.; Egan-Mitchell, B; McCarthy, Colm; McNicholl, B

doi:10.1136/bmj.1.5855.703

Cited by 170 publications

(42 citation statements)

References 8 publications

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“…The incidence of childhood celiac disease shows remarkable variations in different European countries, ranging from 1:300 live births in the western part of Ireland to 1:3500 in other countries (1,2). Variations within the same country have also been reported (3,4).…”

mentioning

confidence: 85%

“…In Sweden, the European country with the highest incidence rate of childhood celiac disease, most of the children, like the Dutch children, present with the typical complaints of chronic diarrhea and malabsorption. However, whereas in Denmark the Down's syndrome (2), cystic fibrosis (2), alopecia (2), cow's milk protein allergy (2), epilepsy (1), juvenile rheumatoid arthritis (1), and chronic autoimmune hepatitis (1). Of the children, 70.2 and 42.2% were below the 10th percentile for, respectively, weight and height at the moment of diagnosis.…”

Section: Ol----'------'------'-----'-------"-_-'--_ L----'_mentioning

confidence: 99%

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Low Incidence of Childhood Celiac Disease in The Netherlands

George

Mearin

Velde³

et al. 1995

Pediatr Res

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confidence: 85%

Section: Ol----'------'------'-----'-------"-_-'--_ L----'_mentioning

confidence: 99%

Low Incidence of Childhood Celiac Disease in The Netherlands

George

Mearin

Velde³

et al. 1995

Pediatr Res

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“…For the calculation of the predictive values, hypothetical incidences of 1:500, 1:1000 and 1:2000 were used based on literature data from other countries (14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Serum antigliadin antibody levels as a screening criterion before jejunal biopsy indication for celiac disease in a developing country

Bahia

Rabello²,

Filho

et al. 2001

Braz J Med Biol Res

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The objective of the present study was to determine the efficacy of detection of antigliadin immunoglobulins G and A (IgG and IgA) for the diagnosis of celiac disease in a developing country, since other enteropathies might alter the levels of these antibodies. Three groups were studied: 22 patients with celiac disease (mean age: 30.6 months), 61 patients with other enteropathies (mean age: 43.3 months), and 46 patients without enteropathies (mean age: 96.9 months). Antigliadin IgG and IgA ELISA showed sensitivity of 90.9 and 95.5%, respectively. With the hypothetical values of prevalence ranging from 1:500 to 1:2000 liveborns, the positive predictive value varied from 8.5 to 2.3% for IgG and from 4.8 to 1.1% for IgA. Considering the patients without enteropathies, specificity was 97.8 and 95.7% for IgG and IgA, respectively. In patients with other enteropathies, specificity was 82.0 and 84.1%, respectively. When patients with and without other enteropathies were considered as a whole, specificity was 88.8 and 91.6%, respectively. The specificity of positive IgG or IgA was 93.5% in children without enteropathies and 78.7% in the presence of other enteropathies. The negative predictive value for hypothetical prevalences varying from 1:500 to 1:2000 liveborns was 99.9%. Thus, even in developing countries where the prevalence of non-celiac enteropathies is high, the determination of serum antigliadin antibody levels is a useful screening test prior to the jejunal biopsy in the investigation of intestinal malabsorption.

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“…Consequently, an elevated incidence of the disease (that in the mid-1970s reached peaks of 1/450-500) was reported in studies from Ireland (Mylotte et al, 1973), Scotland (Logan et al, 1986) and Switzerland (Van Stirum et al, 1982). This increased incidence of CD urged changes in the dietary habit, based on the hypothesis that delayed exposure to gluten could prevent the onset of the disease.…”

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confidence: 95%