Incidence of Cervical Squamous Intraepithelial Lesions in HIV-Infected Women

Ellerbrock, Tedd V.; Chiasson, Mary Ann; Bush, Timothy J.; Sun, Xiao-Wei; Sawo, Dorothy; Brudney, Karen; Wright, Thomas

doi:10.1001/jama.283.8.1031

Cited by 407 publications

(116 citation statements)

References 31 publications

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“…HPV infection and SIL are common in this population. 1,3,12 Women living with HIV may be asymptomatic; however, women with fast progressing SIL must be tested for HIV as SIL may be a sign of immunosuppression. On the 70’s, a hypothesis that HPV infection was involved in cervical carcinogenesis was suggested, 17,18 and subsequent studies showed that nearly all cervical neoplasias occur in HPV-positive patients and only specific types of virus are associated with invasive carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…On the 70’s, a hypothesis that HPV infection was involved in cervical carcinogenesis was suggested, 17,18 and subsequent studies showed that nearly all cervical neoplasias occur in HPV-positive patients and only specific types of virus are associated with invasive carcinoma. 3 …”

Section: Discussionmentioning

confidence: 99%

“…1,2 The prevalence of human papillomavirus infection (HPV) is usually greater among HIV-infected women 3,4 than among HIV-uninfected women; this may be explained by the persistence of HIV viral load, which increases the risk of developing SIL. 5,6 …”

Section: Introductionmentioning

confidence: 99%

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Cervical Cytology and Histopathologic Abnormalities in Women living with AIDS in São Paulo, Brazil

Pinto

Golub

Tancredi

et al. 2011

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background: Women living with HIV/AIDS present with a higher prevalence of human papillomavirus (HPV) infection, higher rates of squamous intraepithelial lesions, and are more susceptible to invasive cervical carcinoma progression. Objective: We assessed the frequency of precursory cervical lesions of cancer and its risk factors for women living with HIV/AIDS. Methods: Sociodemographic, clinical, behavioral, and laboratory data were collected from medical records from 2008 to 2009 and analyzed using forward stepwise logistic regression. Results: Medical records of 631 women were reviewed; mean age at AIDS diagnosis was 34 years old (interquartile range = 29–40 years old), 32% were <16 years old at first sexual intercourse; 61% had ≤5 sexual partners during life; 43% had been living with AIDS for ≥9 years; 47% reported previous sexually transmitted infections; 44% presented with HPV infection; and 10% presented with high squamous intraepithelial lesions. Presenting high squamous intraepithelial lesions was significantly associated with home district Human Development Index, age at AIDS diagnosis (>40 years old), time of AIDS diagnosis (>8 years), CD4+ cell count <350/mm3, and HPV infection. Conclusions: Frequent squamous intraepithelial neoplasia in these women shows the importance of gynecologic examinations in routine care and follow-up required by those who present with cervical lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cervical Cytology and Histopathologic Abnormalities in Women living with AIDS in São Paulo, Brazil

Pinto

Golub

Tancredi

et al. 2011

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…The importance of the immune response in HPV infection is indicated by the increased risk of HPV infection and invasive cervical cancer in HIV-infected women and other immunosuppressed patients 207,282–287 . Women with persistent HPV infections have generally lower lymphocyte function, with lower LC function particularly 288 .…”

Section: Immune Interactionsmentioning

confidence: 99%

The Interaction Between Human Papillomaviruses and the Stromal Microenvironment

Woodby

Scott

Bodily

2016

Progress in Molecular Biology and Translational Science

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Human papillomaviruses (HPV) are small, double-stranded DNA viruses that replicate in stratified squamous epithelia and cause a variety of malignancies. Current efforts in HPV biology are focused on understanding the virus-host interactions that enable HPV to persist for years or decades in the tissue. The importance of interactions between tumor cells and the stromal microenvironment has become increasingly apparent in recent years, but how stromal interactions impact the normal, benign life cycle of HPVs or progression of lesions to cancer is less understood. Furthermore, how productively replicating HPV impacts cells in the stromal environment is also unclear. Here we bring together some of the relevant literature on keratinocyte-stromal interactions and their impacts on HPV biology. We discuss how HPV oncogenes in infected cells manipulate other cells in their environment, and, conversely, how neighboring cells may impact the efficiency or course of HPV infection.

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“…A prospective study showed that one in five HIV-positive women with no evidence of cervical disease developed biopsy-confirmed SILs within 3 years [181]. …”

Section: Anogenital Hpv Infection and Disease In Hiv-positive Womenmentioning

confidence: 99%

Proceedings From the First Asia‐Oceania Research Organisation on Genital Infections and Neoplasia (AOGIN) Meeting

2006

Infectious Diseases in Obstetrics and Gynecology

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Incidence of Cervical Squamous Intraepithelial Lesions in HIV-Infected Women

Abstract: In our study, 1 in 5 HIV-infected women with no evidence of cervical disease developed biopsy-confirmed SILs within 3 years, highlighting the importance of cervical cancer screening programs in this population.

Cited by 407 publications

References 31 publications

Cervical Cytology and Histopathologic Abnormalities in Women living with AIDS in São Paulo, Brazil

Cervical Cytology and Histopathologic Abnormalities in Women living with AIDS in São Paulo, Brazil

The Interaction Between Human Papillomaviruses and the Stromal Microenvironment

Proceedings From the First Asia‐Oceania Research Organisation on Genital Infections and Neoplasia (AOGIN) Meeting

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