Cervical Cytology and Histopathologic Abnormalities in Women living with AIDS in São Paulo, Brazil

Abstract

Background: Women living with HIV/AIDS present with a higher prevalence of human papillomavirus (HPV) infection, higher rates of squamous intraepithelial lesions, and are more susceptible to invasive cervical carcinoma progression. Objective: We assessed the frequency of precursory cervical lesions of cancer and its risk factors for women living with HIV/AIDS. Methods: Sociodemographic, clinical, behavioral, and laboratory data were collected from medical records from 2008 to 2009 and analyzed using forward stepwise logistic regression. Results: Medical records of 631 women were reviewed; mean age at AIDS diagnosis was 34 years old (interquartile range = 29–40 years old), 32% were <16 years old at first sexual intercourse; 61% had ≤5 sexual partners during life; 43% had been living with AIDS for ≥9 years; 47% reported previous sexually transmitted infections; 44% presented with HPV infection; and 10% presented with high squamous intraepithelial lesions. Presenting high squamous intraepithelial lesions was significantly associated with home district Human Development Index, age at AIDS diagnosis (>40 years old), time of AIDS diagnosis (>8 years), CD4+ cell count <350/mm3, and HPV infection. Conclusions: Frequent squamous intraepithelial neoplasia in these women shows the importance of gynecologic examinations in routine care and follow-up required by those who present with cervical lesions.

Evidence of association between hepatitis C virus genotype 2b and nosocomial transmissions in hemodialysis centers from southern Brazil

“…Recently, a nationwide and comprehensive cross-sectional, population-based survey has reported an HCV seropositivity rate of 1.38% [5]. Nevertheless, in the southern region of the country, anti-HCV positive confirmed cases are higher than the national average (9.4 versus 5.4 per 100,000 subjects in 2011, respectively) [6]. …”

Análise histopatológica da cérvice uterina de mulheres em cárcere de Mato Grosso

“…Outras alterações epiteliais ou lesões com malignidades importantes não foram detectadas. É importante destacar que a incidência de lesões intraepiteliais de alto grau apresenta baixa ocorrência e se distribui de forma variável na população geral brasileira, como nas análises realizadas em Goiás, com 0,17% de incidência; em São Paulo, de 2%; Acre, com 2%; Bahia, 0,3%; e Rio Grande do Sul, 0,17% (PINTO et al, 2011).…”

Infecção pelo vírus da hepatite B, HIV e cobertura vacinal em profissionais do sexo feminino em Teresina - PI

“…A doença foi tratada como uma pandemia incurável e mortal por um longo período de tempo . Tem sido considerada uma ocorrência de doença crônica em pacientes soropositivos (REIS; GIR, 2009;PINTO et al, 2011;DI BIAGIO, 2011;GALVÃO et al, 2011).…”