Incidence of Carcinoma in Transmissible Papillomatosis of the Domestic Rabbit

Selbie, F. R.; Robinson, R. H. M.

doi:10.1038/bjc.1948.7

Cited by 9 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunohistochemistry or polymerase chain reaction for papillomavirus in European rabbit papillomas require further investigation. Malignant transformation towards squamous cell carcinoma has been described for Shope papilloma 81,86 but was not observed in papillomas of our European case series.…”

Section: Skin: Epithelial Tumorscontrasting

confidence: 60%

Not Just Uterine Adenocarcinoma—Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (Oryctolagus cuniculus): A Review

Baum

2021

Vet Pathol

View full text Add to dashboard Cite

With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors are less covered in recent editions of textbooks of veterinary pathology than before. We present 1238 cases with neoplastic and non-neoplastic masses in rabbit tissue, submitted from 2008 to 2019, supplemented by a review of the literature on neoplasms in rabbits. Cutaneous masses comprised 47% of submissions. Trichoblastoma was by far the most common skin neoplasm, and nodular suppurative panniculitis was the second most frequent skin nodule in this series. Epithelial as well as mesenchymal cutaneous neoplasms can be virally induced in rabbits (eg, Shope papilloma, myxomatosis) but were infrequent in the current cases. Mammary neoplasms comprised 21% of submitted masses and 94% of these had histologic features of malignancy. Tumors of the female reproductive tract were responsible for 9% of biopsies and were predominantly uterine adenocarcinoma. Polypoid proliferation of rectal mucosa was the most common lesion in the alimentary tract. A broad spectrum of other neoplasms was described, including sarcomas at vaccination sites and ocular posttraumatic sarcomas, comparable to lesions described in cats.

show abstract

Section: Skin: Epithelial Tumorscontrasting

confidence: 60%

Not Just Uterine Adenocarcinoma—Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (Oryctolagus cuniculus): A Review

Baum

2021

Vet Pathol

View full text Add to dashboard Cite

show abstract

“…Nearly half of worldwide ESCC cases occur in China, where ESCC is the fourth leading cause of cancer‐related death (Lu et al ., ). The VX2 tumor model was firstly proposed by Shope in which the carcinoma developed from the papillomas in the domestic rabbits and was proven to be the squamous cell type histologically by Hurst in 1933 (Shope and Hurst, ; Selbie and Robinson, ). Early detection and optimal treatment are vital to improve the patients’ life quality and reduce mortality.…”

Section: Introductionmentioning

confidence: 99%

Study on the diagnosis of rabbit VX2 esophageal cancer and stent-therapy efficacy based on multiphoton microscopy

Huang

Wang

et al. 2015

Scanning

View full text Add to dashboard Cite

Histopathology is the gold standard for diagnosis of esophageal carcinoma. Based on two photon excited fluorescence (TPEF) and second harmonic generation (SHG), multiphoton microscopy (MPM) has become a novel optical tool adjunct to current histopathological techniques without any exogenous contrast agents. We thus investigated the potential of using TPEF and SHG techniques for differentiating cancer tissues from cancer tissues after paclitaxel-eluting stent implantation and normal esophageal tissues which are fresh and unstained without dying from the VX2 esophageal carcinoma rabbit models. Comparisons were made between MPM imaging and gold standard sections for each specimen stained with hematoxylin-eosin (H&E). Our results indicated that the MPM imaging technique could identify and distinguish among normal esophageal tissues, cancer tissues, as well as cancer tissues after stent implantation. Therefore, MPM potentially offers a powerful tool to not only diagnose esophageal cancer but also monitor stent-therapy efficacy.

show abstract

“…The VX2 tumor model, in which the carcinoma is developed from papillomas in domestic rabbits and is proven histologically to be the squamous cell type, was originally proposed by Shope and Hurst in 1933 [10] , [11] , and is now used for studies involving many important organs in the human body, such as the liver, the lung, the kidney, the head and neck [12] – [14] . Rabbits are a moderate-to-large-sized animal, but they have rarely been used as an esophageal VX2 tumor model.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Endoscopic Submuscosal Implantation vs. Surgical Intramuscular Implantation of VX2 Fragments for Establishing a Rabbit Esophageal Tumor Model for Mimicking Human Esophageal Squamous Carcinoma

et al. 2014

View full text Add to dashboard Cite

PurposeThis study was undertaken to establish a rabbit esophageal tumor model for mimicking human esophageal squamous carcinoma (ESC) by endoscopic and surgical implantation of VX2 tumors.MethodsFragments of a VX2 tumour were endoscopically implanted in the submucosal layer of the thoracic esophagus of 32 New Zealand white rabbits, while 34 animals received surgical implantation into the muscular layer. Then, the animals were studied endoscopically and pathologically. The safety and efficiency of the two methods and the pathological features of the animal models were analyzed.ResultsBoth the endoscopic and the surgical method had a relatively high success rate of tumor implantation [93.7% (30/32) vs. 97.1% (33/34)] and tumor growth [86.7% (26/30) vs. 81.8% (27/33)], and the variation in the results was not statistically significant (P>0.05). Compared with those produced by the surgical method, the models produced by the endoscopic method had a higher rate of severe esophageal stricture [61.5% (16/26) vs. 29.6% (8/27)] and of intra-luminal tumor growth [73.1% (19/26) vs. 37.0% (10/27)], and had a lower rate of tumor invasion of adjacent organs [53.8% (14/26) vs. 81.5% (22/27)]; all of these results were statistically significant (P<0.05). However, the difference in the survival time and the rates of tumor regional/distant metastasis [38.5% (10/26) vs. 51.8% (14/27)] between the two methods were not statistically significant (P>0.05).ConclusionThe endoscopic and surgical methods are both safe and effective for establishment of VX2 tumors in the rabbit esophagus. The models produced by the two methods have different pathologic features mimicking that of human ESC. We recommend the models for studies on surgical procedures and minimally invasive treatments.

show abstract

Incidence of Carcinoma in Transmissible Papillomatosis of the Domestic Rabbit

Cited by 9 publications

References 0 publications

Not Just Uterine Adenocarcinoma—Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (Oryctolagus cuniculus): A Review

Not Just Uterine Adenocarcinoma—Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (Oryctolagus cuniculus): A Review

Study on the diagnosis of rabbit VX2 esophageal cancer and stent-therapy efficacy based on multiphoton microscopy

Comparison of Endoscopic Submuscosal Implantation vs. Surgical Intramuscular Implantation of VX2 Fragments for Establishing a Rabbit Esophageal Tumor Model for Mimicking Human Esophageal Squamous Carcinoma

Contact Info

Product

Resources

About